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UniProtKB - J3K844 (SMD_COCIM)
Protein
Sphingomyelinase D
Gene
CIMG_06182
Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Functioni
Catalyzes the hydrolysis of sphingomyelin. Sphingomyelinases D are produced by some spider in their venoms, but also by arthropods such as ticks, or pathogenic bacteria and fungi. They might play a role in pathogenicity through different mechanisms, such as membrane destabilization and host cell penetration, but also pulmonary inflammation and cutaneous lesions.
By similarityCatalytic activityi
- EC:3.1.4.41By similarity
Cofactori
Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 50 | By similarity | 1 | |
Metal bindingi | 70 | MagnesiumBy similarity | 1 | |
Metal bindingi | 72 | MagnesiumBy similarity | 1 | |
Metal bindingi | 118 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- sphingomyelin phosphodiesterase D activity Source: UniProtKB-EC
GO - Biological processi
- lipid catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism, Virulence |
Ligand | Magnesium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Sphingomyelinase D1 Publication (EC:3.1.4.41By similarity)Short name: SMase D1 Publication |
Gene namesi | ORF Names:CIMG_06182 |
Organismi | Coccidioides immitis (strain RS) (Valley fever fungus) |
Taxonomic identifieri | 246410 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › Onygenaceae › Coccidioides › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:CIMG_06182 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000431990 | 22 – 303 | Sphingomyelinase DSequence analysisAdd BLAST | 282 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 296 – 303 | SMD-tailSequence analysis | 8 |
Domaini
The SMD-tail motif is highly conserved and may be responsible for structural stabilization.1 Publication
Sequence similaritiesi
Belongs to the sphingomyelinase D/phospholipase D family.Curated
Keywords - Domaini
SignalPhylogenomic databases
OrthoDBi | 1048800at2759 |
Family and domain databases
Gene3Di | 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR017946, PLC-like_Pdiesterase_TIM-brl |
SUPFAMi | SSF51695, SSF51695, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
J3K844-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSLSLLLCS ALAGLLHVAS CIDVPDQAPL TVDECKCKPT SPKPVYAIAH
60 70 80 90 100
RVLTEEGIQA AIAHGANAIE IDMTAWKSGW WADHDGLPTS GNVTAKAMFR
110 120 130 140 150
EVARLREDGA HLSFVWLDIK NPDWAISGRS SVAYLRKLAR EYLEPAGVRV
160 170 180 190 200
LYGFSNPRNS WGFKEIRNFL NANESVSVWM DSGDAKKIYA GVGRSIPVAQ
210 220 230 240 250
RVVDNGLFSL FWKPYIFDDL RRSSEARDCC TVGKAFGWTI LAGQDRYVDK
260 270 280 290 300
LLGYSGVDGL IYGTMASAYE DSEDTRAAAA LISNWIKNHP DTHRVPTQDD
KPW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GG704912 Genomic DNA Translation: EAS30703.1 |
RefSeqi | XP_001242286.1, XM_001242285.1 |
Genome annotation databases
EnsemblFungii | EAS30703; EAS30703; CIMG_06182 |
GeneIDi | 4561714 |
KEGGi | cim:CIMG_06182 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GG704912 Genomic DNA Translation: EAS30703.1 |
RefSeqi | XP_001242286.1, XM_001242285.1 |
3D structure databases
AlphaFoldDBi | J3K844 |
SMRi | J3K844 |
ModBasei | Search... |
Genome annotation databases
EnsemblFungii | EAS30703; EAS30703; CIMG_06182 |
GeneIDi | 4561714 |
KEGGi | cim:CIMG_06182 |
Organism-specific databases
VEuPathDBi | FungiDB:CIMG_06182 |
Phylogenomic databases
OrthoDBi | 1048800at2759 |
Family and domain databases
Gene3Di | 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR017946, PLC-like_Pdiesterase_TIM-brl |
SUPFAMi | SSF51695, SSF51695, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SMD_COCIM | |
Accessioni | J3K844Primary (citable) accession number: J3K844 Secondary accession number(s): A0A0E1S1R9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 4, 2015 |
Last sequence update: | October 3, 2012 | |
Last modified: | May 25, 2022 | |
This is version 35 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families