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Protein

RNA polymerase II transcription factor B subunit 2

Gene

CIMG_08631

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:CIMG_08631Imported
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)Imported
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000001261 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CIMG_08631

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi246410.XP_001241468.1

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410J3ZI Eukaryota
ENOG410YXPB LUCA
InParanoidiJ3K5W9
KOiK03144
OrthoDBiEOG092C590K

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

J3K5W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVSSSRPLE YLESLPGTVF LKLYQQPSTA LAIFRRMLPH LAKCFVMALL
60 70 80 90 100
YLKDPLPAAE LELWVKAGSK RERDNALSIL SRLHILSSTT TSDHVRAYMV
110 120 130 140 150
TNPFSSSLRQ ALTGGDKQHS FGVMSSMPDP HPMTVSDLDD YARRQWEGVL
160 170 180 190 200
GYMVGTNSLG IQRENVTLSK GVKSLLQACH LVEVRDRRVE ITKEGFAFVL
210 220 230 240 250
QDVNTQVWHI LILYVENAEA IGMDSVEVLS FLFLLSSLEL GQSYDKKHLT
260 270 280 290 300
STQLRTLADL TDFGIVYQHS PASESTRFYP TRLATTLTSD SMALSSSISG
310 320 330 340 350
NLAPAGPNIN AATGAPGTGF IIIETNYRLY AYTSSPLQIS LIALFTTLKY
360 370 380 390 400
RFPNLVTGKL TRQSIRRAVE MGITADQIIS YLTTHAHPQM RKVNASKSTS
410 420 430 440 450
TTAGLLASVL PPTVVDQIRL WQLERDRLKA TPGFLFKDFA SSAEFEAPCR
460 470 480
YAEEIGVLVW KSEKRRMFFV TRHEQVAAFL RSRASRS
Length:487
Mass (Da):54,283
Last modified:May 27, 2015 - v2
Checksum:i476A402889BA10F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704913 Genomic DNA Translation: EAS29885.3
RefSeqiXP_001241468.1, XM_001241467.2

Genome annotation databases

EnsemblFungiiEAS29885; EAS29885; CIMG_08631
GeneIDi4560341
KEGGicim:CIMG_08631

Entry informationi

Entry nameiJ3K5W9_COCIM
AccessioniPrimary (citable) accession number: J3K5W9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: May 27, 2015
Last modified: February 28, 2018
This is version 24 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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