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Protein

NAD kinase

Gene

nadK

Organism
Methanofollis liminatans DSM 4140
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Proton acceptorUniRule annotation1
Binding sitei142NADUniRule annotation1
Binding sitei159NADUniRule annotation1
Binding sitei161NADUniRule annotation1
Binding sitei196NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 64NADUniRule annotation2
Nucleotide bindingi131 – 132NADUniRule annotation2
Nucleotide bindingi172 – 177NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, NADUniRule annotation, NADPUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
ORF Names:Metli_1195Imported
OrganismiMethanofollis liminatans DSM 4140Imported
Taxonomic identifieri28892 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanofollis
Proteomesi
  • UP000005095 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

OrthoDBiPOG093Z07HH

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 1 hit
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

J0RZY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVLLMSRID TPEVLAYADE IRHLLLSLGY TVALEEGTAD VLGERGEALG
60 70 80 90 100
ETDAGIVVAV GGDGTVLLAV QMMKRQIPVI GINRGHVGFL ADLEDREVPA
110 120 130 140 150
FFMNLHEGMR LDRRMRISLF HEGEHLGEAL NEAVIVTARP AKMLRFTIII
160 170 180 190 200
DGIEVEEFRA DGLIIATPTG STAYAMSGGG PIVDPKFDGF LLVPLAPYML
210 220 230 240 250
SSRPHLIDSG RNLKIRLEST KPAQIVLDGR GDLTLGSGAE ISVRRSDAPA
260 270
VFVDAGKNFF LKVREKLHNL
Length:270
Mass (Da):29,352
Last modified:October 3, 2012 - v1
Checksum:iCFC920E4001EBF7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001555 Genomic DNA Translation: EJG07151.1
RefSeqiWP_004038843.1, NZ_CM001555.1

Genome annotation databases

EnsemblBacteriaiEJG07151; EJG07151; Metli_1195
PATRICifig|28892.9.peg.1287

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001555 Genomic DNA Translation: EJG07151.1
RefSeqiWP_004038843.1, NZ_CM001555.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEJG07151; EJG07151; Metli_1195
PATRICifig|28892.9.peg.1287

Phylogenomic databases

OrthoDBiPOG093Z07HH

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 1 hit
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJ0RZY1_9EURY
AccessioniPrimary (citable) accession number: J0RZY1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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