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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Helicobacter pylori Hp H-3
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei75SubstrateUniRule annotation1
Binding sitei89Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processNucleotide metabolismUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00610;UER00666

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotationSAAS annotation (EC:3.6.1.23UniRule annotationSAAS annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:dutUniRule annotationImported
ORF Names:HPHPH3_1134Imported
OrganismiHelicobacter pylori Hp H-3Imported
Taxonomic identifieri992059 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000004029 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliJ0MZT3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 141dUTPaseInterPro annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 64Substrate bindingUniRule annotation3
Regioni79 – 81Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00116 dUTPase_bact, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR008181 dUTPase_1
IPR033704 dUTPase_trimeric
PANTHERiPTHR11241 PTHR11241, 1 hit
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR00576 dut, 1 hit

Sequencei

Sequence statusi: Complete.

J0MZT3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIKIQKIHP NALIPEYQTE GSSGFDLHAV EEVTIKPHSV GLVKIGICLS
60 70 80 90 100
LEVGYELQVR TRSGLALNHQ VMVLNSPGTV DNDYRGEMKV ILANLSDKDF
110 120 130 140
KVRIGDRIAQ GVVQKTYKAE FIECEQLDET SRGSGGFGST GVSKA
Length:145
Mass (Da):15,846
Last modified:October 3, 2012 - v1
Checksum:i006399C1DB25D8F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AKOX01000008 Genomic DNA Translation: EJB79692.1
RefSeqiWP_000694139.1, NZ_AKOX01000008.1

Genome annotation databases

EnsemblBacteriaiEJB79692; EJB79692; HPHPH3_1134
PATRICifig|992059.3.peg.1095

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AKOX01000008 Genomic DNA Translation: EJB79692.1
RefSeqiWP_000694139.1, NZ_AKOX01000008.1

3D structure databases

ProteinModelPortaliJ0MZT3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEJB79692; EJB79692; HPHPH3_1134
PATRICifig|992059.3.peg.1095

Enzyme and pathway databases

UniPathwayi
UPA00610;UER00666

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00116 dUTPase_bact, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR008181 dUTPase_1
IPR033704 dUTPase_trimeric
PANTHERiPTHR11241 PTHR11241, 1 hit
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR00576 dut, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJ0MZT3_HELPX
AccessioniPrimary (citable) accession number: J0MZT3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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