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Protein

Transcription termination factor Rho

Gene

rho

Organism
Helicobacter pylori Hp A-9
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei231ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 193ATPUniRule annotation6
Nucleotide bindingi200 – 205ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseUniRule annotation, Hydrolase, RNA-bindingUniRule annotation
Biological processTranscription, Transcription regulation, Transcription terminationUniRule annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
Alternative name(s):
ATP-dependent helicase RhoUniRule annotation
Gene namesi
Name:rhoUniRule annotationImported
ORF Names:HPHPA9_1045Imported
OrganismiHelicobacter pylori Hp A-9Imported
Taxonomic identifieri992034 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000005483 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliJ0JY80
SMRiJ0JY80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 69Rho_NInterPro annotationAdd BLAST43
Domaini74 – 140CSPInterPro annotationAdd BLAST67
Domaini189 – 380AAAInterPro annotationAdd BLAST192

Sequence similaritiesi

Belongs to the Rho family.UniRule annotation

Family and domain databases

CDDicd04459 Rho_CSD, 1 hit
HAMAPiMF_01884 Rho, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR011129 CSD
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
IPR011112 Rho_N
IPR036269 Rho_N_sf
IPR011113 Rho_RNA-bd
IPR004665 Term_rho
PANTHERiPTHR15184:SF34 PTHR15184:SF34, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF07498 Rho_N, 1 hit
PF07497 Rho_RNA_bind, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00357 CSP, 1 hit
SM00959 Rho_N, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 1 hit
SSF68912 SSF68912, 1 hit
TIGRFAMsiTIGR00767 rho, 1 hit

Sequencei

Sequence statusi: Complete.

J0JY80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNENAPTHKS SHKVKTHTPV SGYHIEDLRT YPTEKLLEIA NKLKVENPQE
60 70 80 90 100
FKRQDLMFEI LKTQVTQGGY ILFTGILEIM PDGYGFLRGF DGSFSDGHND
110 120 130 140 150
TYVSPSQIRR FALRNGDIVT GQVRSPKDQE KYYALLKIEA INYLPSDEIK
160 170 180 190 200
NRPLFDNLTP LFPDEQIKLE YEPTKVTGRM LDLFSPVGKG QRALIVAPPR
210 220 230 240 250
TGKTELMKEL AQGITSNHPE VELIILLVDE RPEEVTDMQR SVKGQVFSST
260 270 280 290 300
FDLPANNHIR IAELVLERAK RRVEMGKDVV VLLDSITRLA RAYNAVTPSS
310 320 330 340 350
GKVLSGGVDA NALHRPKRFF GAARNIEEGG SLTIIATALI ETGSRMDEVI
360 370 380 390 400
FEEFKGTGNS EIVLARNIAD RRIYPAFDIL KSGTRKDNIL LGKDRLTKVW
410 420 430
VLRNVMQQMD DIEALSFVYS KMQQTKDNEE FLNLMNEK
Length:438
Mass (Da):49,545
Last modified:October 3, 2012 - v1
Checksum:iA383ADB7E65C8C98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AKOC01000012 Genomic DNA Translation: EJB43122.1
RefSeqiWP_001004709.1, NZ_AKOC01000012.1

Genome annotation databases

EnsemblBacteriaiEJB43122; EJB43122; HPHPA9_1045
PATRICifig|992034.3.peg.1000

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AKOC01000012 Genomic DNA Translation: EJB43122.1
RefSeqiWP_001004709.1, NZ_AKOC01000012.1

3D structure databases

ProteinModelPortaliJ0JY80
SMRiJ0JY80
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEJB43122; EJB43122; HPHPA9_1045
PATRICifig|992034.3.peg.1000

Family and domain databases

CDDicd04459 Rho_CSD, 1 hit
HAMAPiMF_01884 Rho, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR011129 CSD
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
IPR011112 Rho_N
IPR036269 Rho_N_sf
IPR011113 Rho_RNA-bd
IPR004665 Term_rho
PANTHERiPTHR15184:SF34 PTHR15184:SF34, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF07498 Rho_N, 1 hit
PF07497 Rho_RNA_bind, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00357 CSP, 1 hit
SM00959 Rho_N, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 1 hit
SSF68912 SSF68912, 1 hit
TIGRFAMsiTIGR00767 rho, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJ0JY80_HELPX
AccessioniPrimary (citable) accession number: J0JY80
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: October 25, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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