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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

HMPREF1062_02073

Organism
Bacteroides cellulosilyticus CL02T12C19
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei167UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBCEL997874-HMP:GM8K-2087-MONOMER
UniPathwayi
UPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2UniRule annotation (EC:2.3.1.179UniRule annotation)
Gene namesi
ORF Names:HMPREF1062_02073Imported
OrganismiBacteroides cellulosilyticus CL02T12C19Imported
Taxonomic identifieri997874 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000003741 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 421PKS_KSInterPro annotationAdd BLAST416

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.UniRule annotation

Phylogenomic databases

OrthoDBiPOG091H018O

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR017568 3-oxoacyl-ACP_synth-2
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PIRSFiPIRSF000447 KAS_II, 1 hit
SMARTiView protein in SMART
SM00825 PKS_KS, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR03150 fabF, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

I8W2C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELKRVVVTG LGAITPIGNN VSDFWENLVN GVSGAGPITH FDASLFKTQF
60 70 80 90 100
ACEVKNFEAT KYIDRKEARK MDLYTQYAIA VAKEAVTDSG LDIENEDLNR
110 120 130 140 150
IGVIFGAGIG GIRTFEEEVG NYALTGKENG PKFNPFFIPK MISDIAAGQI
160 170 180 190 200
SIMYGFHGPN YATCSACATS TNAIADAFNL IRLGKANIIV SGGSEAAITV
210 220 230 240 250
GGVGGFNAMH ALSTRNESPT TASRPFSASR DGFVMGEGGG CLVLEELEHA
260 270 280 290 300
KARGAKIYAE VAGVGMSADA HHLTASHPEG LGAKLVMRNA LEDAEMSPEE
310 320 330 340 350
VDYINVHGTS TPVGDISEAK AIKEVFGEHA FELNISSTKS MTGHLLGAAG
360 370 380 390 400
AVEAIASILA IKNGIVPPTI NHEEGDNDEN IDYDLNLTFN KAQKREVNVA
410 420
LSNTFGFGGH NACVIFKKYA E
Length:421
Mass (Da):44,604
Last modified:October 3, 2012 - v1
Checksum:i525C80CA86DA6946
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGXG01000046 Genomic DNA Translation: EIY32785.1
RefSeqiWP_007216814.1, NZ_JH724086.1

Genome annotation databases

EnsemblBacteriaiEIY32785; EIY32785; HMPREF1062_02073
PATRICifig|997874.3.peg.2118

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGXG01000046 Genomic DNA Translation: EIY32785.1
RefSeqiWP_007216814.1, NZ_JH724086.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEIY32785; EIY32785; HMPREF1062_02073
PATRICifig|997874.3.peg.2118

Phylogenomic databases

OrthoDBiPOG091H018O

Enzyme and pathway databases

UniPathwayi
UPA00094

BioCyciBCEL997874-HMP:GM8K-2087-MONOMER

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR017568 3-oxoacyl-ACP_synth-2
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PIRSFiPIRSF000447 KAS_II, 1 hit
SMARTiView protein in SMART
SM00825 PKS_KS, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR03150 fabF, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI8W2C9_9BACE
AccessioniPrimary (citable) accession number: I8W2C9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: March 28, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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