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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 3

Gene

fabH

Organism
Bacteroides cellulosilyticus CL02T12C19
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.UniRule annotationSAAS annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei116UniRule annotation1
Active sitei256UniRule annotation1
Active sitei286UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationSAAS annotation, Multifunctional enzymeUniRule annotationSAAS annotation, Transferase
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3UniRule annotation (EC:2.3.1.180UniRule annotation)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase IIIUniRule annotation
Beta-ketoacyl-ACP synthase IIIUniRule annotation
Short name:
KAS IIIUniRule annotation
Gene namesi
Name:fabHUniRule annotation
ORF Names:HMPREF1062_04661Imported
OrganismiBacteroides cellulosilyticus CL02T12C19Imported
Taxonomic identifieri997874 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000003741 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 188ACP_syn_IIIInterPro annotationAdd BLAST79
Domaini241 – 327ACP_syn_III_CInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni257 – 261ACP-bindingUniRule annotation5

Domaini

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.UniRule annotation

Sequence similaritiesi

Belongs to the FabH family.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H02M9

Family and domain databases

Gene3Di3.40.47.10, 1 hit
HAMAPiMF_01815 FabH, 1 hit
InterProiView protein in InterPro
IPR013751 ACP_syn_III
IPR013747 ACP_syn_III_C
IPR004655 FabH_synth
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF08545 ACP_syn_III, 1 hit
PF08541 ACP_syn_III_C, 1 hit
SUPFAMiSSF53901 SSF53901, 1 hit
TIGRFAMsiTIGR00747 fabH, 1 hit

Sequencei

Sequence statusi: Complete.

I8VHP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKINAVITG VGGYVPDYIL TNEEISRMVD TNDEWIMTRI GVKERHILNE
60 70 80 90 100
EGLGTSYMAR KAAKQLMQRT GSNPDDIDLV IVATTTPDYH FPSTASILCD
110 120 130 140 150
KLGLKHAFAF DLQAACSGFL YLLETGANFI RSGRYKKIIL VGGDKMSSMV
160 170 180 190 200
DYTERATCPI FGDGAAAVMM EPTTEDVGVM DAILRTDGKG LPFLHMKAGG
210 220 230 240 250
SVCPPSYFTV DNHMHFLYQE GRTVFKYAVS NMSDACVAIA ERNNLTKDNI
260 270 280 290 300
DWIIPHQANL RIIDAVAHRL EVPREKVMIN IERYGNTSAG TLPLCLWDFE
310 320 330
DKLKKGDNLI FTAFGAGFTW GAVYVKWGYD GKKQ
Length:334
Mass (Da):37,108
Last modified:October 3, 2012 - v1
Checksum:iC35AA5045C985B7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGXG01000095 Genomic DNA Translation: EIY24847.1
RefSeqiWP_007210034.1, NZ_JH724089.1

Genome annotation databases

EnsemblBacteriaiEIY24847; EIY24847; HMPREF1062_04661
GeneIDi29610935
PATRICifig|997874.3.peg.4765

Similar proteinsi

Entry informationi

Entry nameiI8VHP0_9BACE
AccessioniPrimary (citable) accession number: I8VHP0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: February 28, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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