Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

3-oxoacyl-(Acyl-carrier-protein) synthase

Gene

Ao3042_00375

Organism
Aspergillus oryzae (strain 3.042) (Yellow koji mold)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1227For beta-ketoacyl synthase activityUniRule annotation1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1696MagnesiumUniRule annotation1
Metal bindingi1697Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi1698MagnesiumUniRule annotation1
Metal bindingi1795MagnesiumUniRule annotation1
Metal bindingi1796Magnesium; via carbonyl oxygenUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
3-oxoacyl-(Acyl-carrier-protein) synthaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:Ao3042_00375Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus oryzae (strain 3.042) (Yellow koji mold)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1160506 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002812 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei203O-(pantetheine 4'-phosphoryl)serineUniRule annotation1

Keywords - PTMi

PhosphopantetheineUniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1080 – 1554PKS_KSInterPro annotationAdd BLAST475

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili861 – 881Sequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fungal fatty acid synthetase subunit alpha family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
EOG092C01HX

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.47.10, 3 hits
3.90.470.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR026025 FAS_alpha_yeast
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR036291 NAD(P)-bd_dom_sf
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR004568 Ppantetheine-prot_Trfase_dom
IPR002347 SDR_fam
IPR016039 Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01648 ACPS, 1 hit
PF00106 adh_short, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000454 FAS_yeast_alpha, 2 hits

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00825 PKS_KS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit
SSF53901 SSF53901, 2 hits
SSF56214 SSF56214, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00556 pantethn_trn, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

I8ISM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMHSNLTLD RSSVGHCENK DRSQLALKLL IELLALYVLS PAEFPRIETQ
60 70 80 90 100
HQLITGCPPV CRFVEVGPRT TLATMAKKSA ARHYRSYANS QWSHLQFLSY
110 120 130 140 150
QDNKDEIFYH YIDSKVCSDE KGKAGPPTSH DLSLLPLLPG SLREPQQCVP
160 170 180 190 200
SKAPPLRASP SIDVSLSCNH IALAMTAQKL RQPFDKVAMG KTVRELSGGM
210 220 230 240 250
GKSTLQNELV GDLVAEFGRV PEGVEDMTLI ALGEALQGAF VGKPAKHMTT
260 270 280 290 300
LIARLISRKM PAGFNQNSMQ DYICSRWGFS KAHSLIPICL AITIEPTARL
310 320 330 340 350
ANAHAAQGYI DELISRYATF QGISLVPADG LYIEQSELMP SAVSLSDRQV
360 370 380 390 400
IQEQQRSYYR KHFDILAKYL EIDLGASGQP PLDITYQETL ERWNAEFDDH
410 420 430 440 450
FSEGIKSMFD IMQARNYDSW WNWAREELIQ WLHKVASDPL DVALPRKGNR
460 470 480 490 500
LRRILNRWDP SCSDIVEAMI KSPRPVGCPK QAISSCSDIR LALKEILRLG
510 520 530 540 550
DLDLASEPIY IYSFPALCPK TTISSSGQLG YMETARKVSS YPDVVCQGRL
560 570 580 590 600
CADDLETMIP FVHIKSRRNE GSWKYDADAT SILHAALGTG TTTGFSYASK
610 620 630 640 650
TVLVTGAGPD SIGAQVVHGL LCGGARVVVT TSRTISESAS FYQELYRRCG
660 670 680 690 700
ARGASLTVFP MNQASKRDCE NLIEHIYSAD SPIDGDLDYF IPFAAVPQAG
710 720 730 740 750
ELDKLGSRQE LAHRAMLVNL LRIVGFIRQH KEKRRISCRP TTIVLPMSCN
760 770 780 790 800
EGSFGGDGLY PESKAGLKTL LNRFHSESWS SYITICGAVM GWTRGTGLMH
810 820 830 840 850
SSNIIAEEVE KLGVITFTQA EMAFNILALM TPGITTLAEQ APVYADLTGG
860 870 880 890 900
LGLLWDIKDH ISGSRRRLNE ESQIRKALQE EDTRHVSVLF GPQQQQPKDT
910 920 930 940 950
GVNISRRRAH IQIPFPILQP FDDLRVSLPN LQGMIDLSRT VVVVGFSELG
960 970 980 990 1000
PWGNARTRWE MEHQGWFSLE GYIEIAWIMG LIKHVDGDWK GRHYVGWVDA
1010 1020 1030 1040 1050
ETQEPIHDQD IPHKYHEHIM SNTGLRLIEP EGVDTYIPSQ KEFLQEVAVE
1060 1070 1080 1090 1100
EDLPPFECSK LSAEAFKLRH GNNITLQPIP GSDSYRVFLK KGAVLMIAKT
1110 1120 1130 1140 1150
IPFHQSVAGI VPTGWDALRY GIPEEIIQQV DTTTLYALCC VSEAFLSAGI
1160 1170 1180 1190 1200
NDPYDIYQHI HVSELANCLG TGGGPMKVIQ NMYRDRFLDR QVRGDIILEH
1210 1220 1230 1240 1250
FLNTMGAWVN MLLLSASGPL KTPVGACATA LESLDIGCDA IISGNCKVAI
1260 1270 1280 1290 1300
VGGCDDYREE LSFEFDSIKA TANCVEELAR GRLPGEISRP TASSRSGFAE
1310 1320 1330 1340 1350
SAGCGVQLLM NAELALKLGL PIYGIVAYSQ MASDQAGRSI PAPGKGILTA
1360 1370 1380 1390 1400
AREHHEAKSS PFLDFNFRRA GFDEEVADIE QKSIGGSVGR MQSSGAAQAV
1410 1420 1430 1440 1450
AEQSRKLKVQ DTQWRWAHNI RLQDPSISPL RAALATWGLG VDDIGVVSMH
1460 1470 1480 1490 1500
GTSTKANDIN EGEVINTQMD HLGRRKGNPL LCVCQKSLTG HPKAAAGAWQ
1510 1520 1530 1540 1550
LNGCMQILQN GIVPGNRNAD NIDAQLRQFE HLVYPMESIK TRGIKATMIT
1560 1570 1580 1590 1600
SFGFGQKGAI AIVVTPSYLL ASLPASTYEE YRVRVTQRQR AANPELVSRI
1610 1620 1630 1640 1650
LNNCIVQIKS LPPWENKDAT EKVFLDPGSC RQDVTTEFTN EAHANSSKLV
1660 1670 1680 1690 1700
NTTTDRNSQI VENEDEGTSL SCLVEKMLID AVGRSKGTSS PSIGVDVEEI
1710 1720 1730 1740 1750
ASINTENETF LQRNFTLAER EYCLKAPNPQ ASFAGRWSAK EAVFKSLHAS
1760 1770 1780 1790 1800
SSGPGAPMQD IEVLSHCGVP IITLHGEVKD IAQAKDIGRV EVSISHTSKA
1810
AVAIAVAVKG
Length:1,810
Mass (Da):199,107
Last modified:October 3, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4E0C7CF2DA96410
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AKHY01000079 Genomic DNA Translation: EIT82421.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EIT82421; EIT82421; Ao3042_00375

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AKHY01000079 Genomic DNA Translation: EIT82421.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEIT82421; EIT82421; Ao3042_00375

Phylogenomic databases

OrthoDBiEOG092C01HX

Family and domain databases

Gene3Di3.40.47.10, 3 hits
3.90.470.20, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR026025 FAS_alpha_yeast
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR036291 NAD(P)-bd_dom_sf
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR004568 Ppantetheine-prot_Trfase_dom
IPR002347 SDR_fam
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
PF00106 adh_short, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PIRSFiPIRSF000454 FAS_yeast_alpha, 2 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SMARTiView protein in SMART
SM00825 PKS_KS, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF53901 SSF53901, 2 hits
SSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00556 pantethn_trn, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI8ISM4_ASPO3
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I8ISM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again