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Entry version 47 (02 Jun 2021)
Sequence version 2 (16 Apr 2014)
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Protein
Submitted name:

E1-E2 ATPase family protein

Gene

TTHERM_00145530

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocaseARBA annotation

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.3.10.15, the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
E1-E2 ATPase family proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TTHERM_00145530Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetrahymena thermophila (strain SB210)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri312017 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009168 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei86 – 102HelicalSequence analysisAdd BLAST17
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Transmembranei1120 – 1141HelicalSequence analysisAdd BLAST22
Transmembranei1147 – 1167HelicalSequence analysisAdd BLAST21
Transmembranei1188 – 1209HelicalSequence analysisAdd BLAST22
Transmembranei1271 – 1292HelicalSequence analysisAdd BLAST22
Transmembranei1304 – 1337HelicalSequence analysisAdd BLAST34

Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni829 – 850DisorderedSequence analysisAdd BLAST22
Regioni866 – 894DisorderedSequence analysisAdd BLAST29
Regioni959 – 983DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi875 – 894Basic and acidic residuesSequence analysisAdd BLAST20

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0208, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
I7MI73

Database of Orthologous Groups

More...
OrthoDBi
172453at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 2 hits
3.40.50.1000, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR001757, P_typ_ATPase

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01494, ATPase_P-type, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

I7MI73-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRKIKEFFI IKQILYFLEK SNLQKIQVTN IFKQYRIRIN FQNSSKVMDE
60 70 80 90 100
QELKINGQIK IINSQIEGEC YIQEVYALKQ QQYKQFLVIL LNIITFGGYY
110 120 130 140 150
LLENWYERSL LKLRYCYTDD IKQATHFLIV QLDNTFQIVK RNDIMIPEEE
160 170 180 190 200
NFEIQLQSAI SFDNRFLRYI YSEEEKYFKC IHFNYTNFLE KNQLGRKGLN
210 220 230 240 250
QQQLQLLEQC YGKCIMQIPI PSYWSYLHKE LINPFFMFQI FSVCIWAYDD
260 270 280 290 300
YYAFCIAITL ILSISTASNI CQIRSNLASF TKIAFYETEI MIKRDKIEKQ
310 320 330 340 350
TSSNILPGDL FYINDQMKVP CDCILIQGQA LVNEASLTGE SVPVLKYNYE
360 370 380 390 400
FNEEVDKKCI LYEGTSVIQI QNNTSEHGCL ALAIRTGFTT HRGQLVRSIL
410 420 430 440 450
FPRPHSFKFY EESIKFLKFL FALTFVAFAI LLPRLYQTME LHYIALKLTD
460 470 480 490 500
LLTVTVPPSL PFALQVGVVF SMQMLKQKKI YCINSEKVVV GGRVDTVVFD
510 520 530 540 550
KTGTLTEDRM DLKGFLPIDD NGNFFKNELV KEDILNVFQK ENTQHISKSM
560 570 580 590 600
QISLNCMGSC HSIMIRKNQQ CSPKQDALQN NYKNHLIGDP MEIQLLNISG
610 620 630 640 650
CKLYANGDIS SSFGQQFKII KTLEFSSERQ KMTVICEDKS ELIQENKFLY
660 670 680 690 700
VFSKGAPEAI HKICNNYPKN YNKMLDKYTQ EGLRVLSLAY KKLPFSLISQ
710 720 730 740 750
FQQNSSQNTD QNNSNVNTNN LQPESIESEM NFLGFVFFEN PLKEATAQTL
760 770 780 790 800
QQLKEAKINI IMATGDNPQT ALSVGEKCHF FDFEDNVTFI NLAQLGNNKR
810 820 830 840 850
LTLTNSKFNT YAEVSEVDEL DEYLSDELSS FNSTDSQENK DQSEQPFGKD
860 870 880 890 900
KEQLKLLKSL KQAEELNSQG RPRDLISKNE NDERKKLSNK ESSQVDDIEL
910 920 930 940 950
KDNILIQQKS SGNKSQTKDI LNGEIKQKCK VNEKQDQLYI CDKNSTTSSS
960 970 980 990 1000
QKIGDESIDI ENDQQLNKQS NSNSSEDLKE EPDSLHLPIS QYVLDSFIRE
1010 1020 1030 1040 1050
ALNQKSEGFV MNGAVFDEIY FKGEINDLSL MLLEKTRIFA RMKPNHKTYL
1060 1070 1080 1090 1100
VELLQKRQKA VAMVGDGAND CGALKQADIG LALSQLEASI SAPFSGECIS
1110 1120 1130 1140 1150
NIIEVLIQCR AGLKTAFNNF NFIAMYSIVQ FTTTTILYYC FSMQSDLQLL
1160 1170 1180 1190 1200
YIDILVVSSL ILTMGMTSAS NKLSMQLPDQ SLISLKNMLS LGGHTLLNII
1210 1220 1230 1240 1250
TQLVILFLLS KQSFFEGIEA NKQFYEKEDI MTWNSSEVST LFLFSNFIYL
1260 1270 1280 1290 1300
ALSICYSDGK PFKNNFYTNK LFICNFMVLL AYCIQMCLVP SLNYYYFYIN
1310 1320 1330 1340
TSMSFSWCSF MCIAGIGYIL LSYFYENTLL GIIYAALQKK TKKE
Length:1,344
Mass (Da):154,825
Last modified:April 16, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AC0E05544EED996
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GG662793 Genomic DNA Translation: EAR90948.2

NCBI Reference Sequences

More...
RefSeqi
XP_001011193.2, XM_001011193.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7836611

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tet:TTHERM_00145530

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662793 Genomic DNA Translation: EAR90948.2
RefSeqiXP_001011193.2, XM_001011193.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi3.A.3.10.15, the p-type atpase (p-atpase) superfamily

Genome annotation databases

GeneIDi7836611
KEGGitet:TTHERM_00145530

Phylogenomic databases

eggNOGiKOG0208, Eukaryota
InParanoidiI7MI73
OrthoDBi172453at2759

Family and domain databases

Gene3Di3.40.1110.10, 2 hits
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR001757, P_typ_ATPase
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01494, ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI7MI73_TETTS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I7MI73
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: April 16, 2014
Last modified: June 2, 2021
This is version 47 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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