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Entry version 25 (02 Jun 2021)
Sequence version 2 (16 Apr 2014)
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Protein
Submitted name:

Transmembrane protein, putative

Gene

TTHERM_00681830

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.17.6.8, the calcium-dependent chloride channel (ca-clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transmembrane protein, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TTHERM_00681830Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetrahymena thermophila (strain SB210)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri312017 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009168 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei535 – 556HelicalSequence analysisAdd BLAST22
Transmembranei576 – 598HelicalSequence analysisAdd BLAST23
Transmembranei675 – 698HelicalSequence analysisAdd BLAST24
Transmembranei704 – 727HelicalSequence analysisAdd BLAST24
Transmembranei748 – 769HelicalSequence analysisAdd BLAST22
Transmembranei875 – 897HelicalSequence analysisAdd BLAST23
Transmembranei918 – 936HelicalSequence analysisAdd BLAST19
Transmembranei978 – 997HelicalSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 61DisorderedSequence analysisAdd BLAST61
Regioni301 – 324DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili408 – 447Sequence analysisAdd BLAST40
Coiled coili1024 – 1044Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 28Polar residuesSequence analysisAdd BLAST28
Compositional biasi46 – 61Polar residuesSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

I7MB08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSELSSIS SQSEMQSSSS SETSSQQGSK KEYIDKRKRK MNNKFSSANN
60 70 80 90 100
KRIHQLRKSQ SHNSDLLNII PSSTTSIINS QRKKSIKFNL SSNQEVNLGD
110 120 130 140 150
ENAFQQRINR GRRKSRFSKT DFLCEDVSPF KSLQMRKQNS QQLILKRKIS
160 170 180 190 200
DGDYPQSILK KSSFERSKSM IESPANIIID SNPSPKMLQN RRHNQIPSLE
210 220 230 240 250
FIMNESNPQI FYNFNSPTNQ ILNRNNSQIS TAIFPPQDSI QNLNEKQNDY
260 270 280 290 300
VKQPNILKNN NDLENNFFGD NYRQRPQRLS LENINQQIKL QLPNNLNISD
310 320 330 340 350
ISQQNNSNPS LNNFSNSNNA HTPQSRNAYQ LNSLQLNNSV QTPSSQRNSK
360 370 380 390 400
NQNQIENING NIGFSDLALQ YTSNSTQAYS NPNLPNIITT QGNHHHRSPS
410 420 430 440 450
QQQIINKKKD YQEVLKELVD TQERLRAEEE KNEYLSLELK KNQEKNNALL
460 470 480 490 500
RQQEILLKKS SFKQSVLREM NQKLNNMQNC NKLVAIHVPF NQKIMSKINK
510 520 530 540 550
MYTLIFYETI FLSQNALKRQ PFFCQNSLQY VKNSIYIYNL LVINNLLSFI
560 570 580 590 600
VAPTIFKQKT NAKNIESYFY SAYDSSLISQ IAFQIFITIL VLTIAHLVNL
610 620 630 640 650
SNMKRQYIRV KSKGKDKINL FKLVFNSFDF KESKSEQQVD YFQEKYSSNL
660 670 680 690 700
KQYIIKKIKI NSADKSPKIL IFLKYFLIFI YSGITFSALF VLKIILSLEY
710 720 730 740 750
SEQIFYQGIV LSFMTIGMCE LVSILYSKIN DLQCLNLDKN NLKEICKIQS
760 770 780 790 800
VSVLILSCYF VVSTLNIIFQ KQDFSFLASI KTSFNFIQSD PNSKQHQNGF
810 820 830 840 850
QIECPEKIVS YIMIQYFVLL NAKILVKNVL RFSKNKLFHI FYQKQSYKKS
860 870 880 890 900
QNFEFYENQH YDCLLFLLIL INQSFFLWSS LFGLLLFIVK FLINYAILRN
910 920 930 940 950
SKVLNFSQYQ SFQIQNRFNQ DFTYVLIIFI LYSFLLNSLS YQKFFDQNGQ
960 970 980 990 1000
VCGPFQGNQN ISSYIYENLF TQPLTQQIYQ IITWPPLLWI LLLSYLMRQW
1010 1020 1030 1040 1050
ISNLSGSEWK SEKKNQGKMM KEVNKHYQQK LQNLEVKIKN TKTILVSSQN

FQINKNQ
Length:1,057
Mass (Da):123,620
Last modified:April 16, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D03984E631DEE7A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GG662247 Genomic DNA Translation: EAS07076.2

NCBI Reference Sequences

More...
RefSeqi
XP_001027318.2, XM_001027318.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7824726

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tet:TTHERM_00681830

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662247 Genomic DNA Translation: EAS07076.2
RefSeqiXP_001027318.2, XM_001027318.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.A.17.6.8, the calcium-dependent chloride channel (ca-clc) family

Genome annotation databases

GeneIDi7824726
KEGGitet:TTHERM_00681830

Family and domain databases

InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
PROSITEiView protein in PROSITE
PS51450, LRR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI7MB08_TETTS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I7MB08
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: April 16, 2014
Last modified: June 2, 2021
This is version 25 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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