The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - I7FD23 (I7FD23_MYCS2)
Protein
Bcr/CflA family efflux transporter
Gene
MSMEI_2916
Organism
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- xenobiotic transmembrane transporter activity Source: InterPro
GO - Biological processi
Keywordsi
Biological process | TransportUniRule annotationARBA annotation |
Protein family/group databases
TCDBi | 2.A.1.2.97, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Bcr/CflA family efflux transporterUniRule annotation |
Gene namesi | Ordered Locus Names:MSMEI_2916Imported |
Organismi | Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)Imported |
Taxonomic identifieri | 246196 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycolicibacterium › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-UniRule
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 54 – 73 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 85 – 103 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 109 – 130 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 142 – 166 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 172 – 192 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 222 – 240 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 260 – 281 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 288 – 309 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 315 – 340 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 352 – 372 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 378 – 398 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membraneUniRule annotation, MembraneStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 406 | MFSInterPro annotationAdd BLAST | 389 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationFamily and domain databases
InterProi | View protein in InterPro IPR004812, Efflux_drug-R_Bcr/CmlA IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00710, efflux_Bcr_CflA, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit |
i Sequence
Sequence statusi: Complete.
I7FD23-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMRIRTAAPG TTTPTLALII LLALLNAVTP FSVDMYMSAF PAMAVEFGTS
60 70 80 90 100
ASVVQLTLTT FLIGLATGQL FIGQLSDRLG RRGPLLVGIV ACLVASLLCA
110 120 130 140 150
VSPSIEVLIM LRFVQGFAGA AGIVIARAII SDRSKGSQAA KLYSVMMVIG
160 170 180 190 200
VLAPILAPVL GGQVVAGFGW RAVFLALAGL NLVMLLGALF MAGESLPPEA
210 220 230 240 250
RRPAGLKAFA GSAASVLTNR RFMGYTLTLS CSGAAMFSYI SASPFVLQNI
260 270 280 290 300
IGLSPRAFSF TFGGCALAVA VSGVISARLV GRFGPRKLLL GGVSAMVVVA
310 320 330 340 350
ALMLLNVTVG GVVPAVTVAL MACFMGTVGF TFANATTLAI GEVRHAAGTG
360 370 380 390 400
SAVIGFLQYG LGAVASPLVG LAGEHSAVPM GVAMFTCAAL AATALLVLTR
410 420
GHIPSYDDEL ADLDADLTAV SAGESTAR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001663 Genomic DNA Translation: AFP39380.1 |
Genome annotation databases
EnsemblBacteriai | AFP39380; AFP39380; MSMEI_2916 |
KEGGi | msg:MSMEI_2916 |
PATRICi | fig|246196.56.peg.2993 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001663 Genomic DNA Translation: AFP39380.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
TCDBi | 2.A.1.2.97, the major facilitator superfamily (mfs) |
Genome annotation databases
EnsemblBacteriai | AFP39380; AFP39380; MSMEI_2916 |
KEGGi | msg:MSMEI_2916 |
PATRICi | fig|246196.56.peg.2993 |
Family and domain databases
InterProi | View protein in InterPro IPR004812, Efflux_drug-R_Bcr/CmlA IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00710, efflux_Bcr_CflA, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | I7FD23_MYCS2 | |
Accessioni | I7FD23Primary (citable) accession number: I7FD23 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | May 25, 2022 | |
This is version 45 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |