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Protein

HTH-type transcriptional regulator MmpR5

Gene

mmpR5

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Controls the expression level of the Mmps2-MmpL2, MmpS4-MmpL4, and MmpS5-MmpL5 transport systems. Also controls its own expression. Acts by binding directly to the promoter regions.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi53 – 76H-T-H motifCuratedAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MmpR5Curated
Gene namesi
Name:mmpR51 Publication
Ordered Locus Names:Rv0678Imported, RVBD_0678Imported
ORF Names:LH57_03665Imported, P425_00707Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0678

Pathology & Biotechi

Disruption phenotypei

Mutations or insertions/deletions that inactivate MmpR5, or decrease its activity, lead to increased levels of MmpL5 and MmpS5, and to non-target based resistance to azoles, clofazimine and bedaquiline.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi88D → A: Decreases DNA binding. 1 Publication1
Mutagenesisi90R → A: Decreases DNA binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004327681 – 165HTH-type transcriptional regulator MmpR5Add BLAST165

Proteomic databases

PaxDbiI6Y8F7
PRIDEiI6Y8F7

Expressioni

Inductioni

Negatively autoregulated.2 Publications

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi83332.Rv0678

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliI6Y8F7
SMRiI6Y8F7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 151HTH marR-typeCuratedAdd BLAST151

Phylogenomic databases

eggNOGiENOG410600Z Bacteria
ENOG41128QY LUCA
OMAiWLLICDP
PhylomeDBiI6Y8F7

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
SUPFAMiSSF46785 SSF46785, 1 hit

Sequencei

Sequence statusi: Complete.

I6Y8F7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVNDGVDQM GAEPDIMEFV EQMGGYFESR SLTRLAGRLL GWLLVCDPER
60 70 80 90 100
QSSEELATAL AASSGGISTN ARMLIQFGFI ERLAVAGDRR TYFRLRPNAF
110 120 130 140 150
AAGERERIRA MAELQDLADV GLRALGDAPP QRSRRLREMR DLLAYMENVV
160
SDALGRYSQR TGEDD
Length:165
Mass (Da):18,379
Last modified:October 3, 2012 - v1
Checksum:iAD3C974B4DFCDF8A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti63S → R in CFZ-R1; leads to increased expression of mmpL5 and partial resistance to both clofazimine and bedaquiline. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003248 Genomic DNA Translation: AFN48550.1
CP009480 Genomic DNA Translation: AIR13406.1
AL123456 Genomic DNA Translation: CCP43421.1
JLDD01000006 Genomic DNA Translation: KBJ39304.1
RefSeqiNP_215192.1, NC_000962.3
WP_003403442.1, NZ_NVQJ01000007.1

Genome annotation databases

EnsemblBacteriaiAFN48550; AFN48550; RVBD_0678
AIR13406; AIR13406; LH57_03665
CCP43421; CCP43421; Rv0678
KBJ39304; KBJ39304; P425_00707
GeneIDi888235
KEGGimtu:Rv0678
mtv:RVBD_0678
PATRICifig|83332.111.peg.752

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003248 Genomic DNA Translation: AFN48550.1
CP009480 Genomic DNA Translation: AIR13406.1
AL123456 Genomic DNA Translation: CCP43421.1
JLDD01000006 Genomic DNA Translation: KBJ39304.1
RefSeqiNP_215192.1, NC_000962.3
WP_003403442.1, NZ_NVQJ01000007.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NB5X-ray1.64A/B/C/D2-165[»]
ProteinModelPortaliI6Y8F7
SMRiI6Y8F7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0678

Proteomic databases

PaxDbiI6Y8F7
PRIDEiI6Y8F7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFN48550; AFN48550; RVBD_0678
AIR13406; AIR13406; LH57_03665
CCP43421; CCP43421; Rv0678
KBJ39304; KBJ39304; P425_00707
GeneIDi888235
KEGGimtu:Rv0678
mtv:RVBD_0678
PATRICifig|83332.111.peg.752

Organism-specific databases

TubercuListiRv0678

Phylogenomic databases

eggNOGiENOG410600Z Bacteria
ENOG41128QY LUCA
OMAiWLLICDP
PhylomeDBiI6Y8F7

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
SUPFAMiSSF46785 SSF46785, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMMPR5_MYCTU
AccessioniPrimary (citable) accession number: I6Y8F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2015
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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