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Entry version 32 (29 Sep 2021)
Sequence version 1 (03 Oct 2012)
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Protein
Submitted name:

Pleiotropic drug resistance transporter 5

Gene

PDR5

Organism
Nicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi207 – 214ATPPROSITE-ProRule annotation8
Nucleotide bindingi941 – 948ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportARBA annotation
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.205.24, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pleiotropic drug resistance transporter 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDR5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4092 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei543 – 564HelicalSequence analysisAdd BLAST22
Transmembranei576 – 602HelicalSequence analysisAdd BLAST27
Transmembranei622 – 649HelicalSequence analysisAdd BLAST28
Transmembranei686 – 708HelicalSequence analysisAdd BLAST23
Transmembranei771 – 797HelicalSequence analysisAdd BLAST27
Transmembranei1242 – 1260HelicalSequence analysisAdd BLAST19
Transmembranei1272 – 1288HelicalSequence analysisAdd BLAST17
Transmembranei1328 – 1348HelicalSequence analysisAdd BLAST21
Transmembranei1355 – 1372HelicalSequence analysisAdd BLAST18
Transmembranei1384 – 1404HelicalSequence analysisAdd BLAST21
Transmembranei1416 – 1436HelicalSequence analysisAdd BLAST21
Transmembranei1467 – 1489HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
I6XGC6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini174 – 447ABC transporterInterPro annotationAdd BLAST274
Domaini896 – 1148ABC transporterInterPro annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49
Regioni808 – 861DisorderedSequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 31Polar residuesSequence analysisAdd BLAST23
Compositional biasi830 – 858Basic and acidic residuesSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. [View classification]ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03233, ABCG_PDR_domain1, 1 hit
cd03232, ABCG_PDR_domain2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR029481, ABC_trans_N
IPR003439, ABC_transporter-like
IPR043926, ABCG_dom
IPR034001, ABCG_PDR_1
IPR034003, ABCG_PDR_2
IPR027417, P-loop_NTPase
IPR013581, PDR_assoc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF19055, ABC2_membrane_7, 2 hits
PF00005, ABC_tran, 2 hits
PF14510, ABC_trans_N, 1 hit
PF08370, PDR_assoc, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

I6XGC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEANGGPRRL GSSRSSMSRT MSRSRSRASW NVEDVFNPMP SRRSTRGEED
60 70 80 90 100
EEALTWAALE KLPTYDRLRK TVLKSVMESE NNQGNKKVVH KEVDVRNLGM
110 120 130 140 150
NERQEFIDRV FRVAEEDNEK FMRKFRNRID KVGITLPTVE VRYEHLTIEA
160 170 180 190 200
DCYIGDRALP TLPNAARNIA ESALSCVGIT LAEKTKLTIL KDASGIIKPS
210 220 230 240 250
RMTLLLGPPS SGKTTLLLAL AGKLDPTLKV RGEITYNGHG LKEFVPQKTS
260 270 280 290 300
AYISQNDVHV AEMTVKETLD FSARCQGVGS RYELLTELAR RERDAGIFPE
310 320 330 340 350
AEIDLFMKAT AMEGVESSLI TDYTLRILGL DVCRDTIVGD EMIRGISGGQ
360 370 380 390 400
KKRVTTGEMI VGPTKTLFTD EISTGLDSST TFQIVKCLQQ IVHLTEATVL
410 420 430 440 450
MSLLQPAPET FDLFDDIILL SEGQIVYQGP REHVLEFFET CGFRCPERKG
460 470 480 490 500
TADFLQEVTS RKDQEQYWAN RHRPYQYISV TEFAKRFKRF HVGLRIENEL
510 520 530 540 550
SVPYDKTRSH PAALIFKKYT VPILELLKTN FDKEWLLIKR NSFVYVFKTV
560 570 580 590 600
QIIIVALIGS TVFLRTKMHT NTVDDGAIYV GALLFGMVIN MFNGFSELAM
610 620 630 640 650
IIQRLPVFYK HRDLLFHPPW TFTLPTVLLK VPISVFETIV WMVMTYYTIG
660 670 680 690 700
YAPEASRFFK QSLLTFLIQQ MAAGLFRLTA GVCRTMIIAN TGGALMLLLI
710 720 730 740 750
FLLCGFILPR GSIPDWWRWG YWVSPLSYGF NAFTVNEMFA PRWMNKFGPD
760 770 780 790 800
GTTRLGLQVM KNFDVFTERR WFWIGAAALL GFTILFNVLF TLVLVYLSPL
810 820 830 840 850
NKPQATLSKE QASDMEADQE ESTGSPRLRI SQSKRDDLPR SLSAADGNKT
860 870 880 890 900
REMEIRRMSS RTSSSGFYRN EDANLEAANG VAAKKGMILP FTPLAMSFDD
910 920 930 940 950
VSYFVDMPPE MKDQGVTEDK LQLLREVTGA FRPGVLTALM GVSGAGKTTL
960 970 980 990 1000
MDVLAGRKTG GYIEGDVRIS GFPKNQETFA RVSGYCEQTD IHSPQVTIHE
1010 1020 1030 1040 1050
SLIFSAFLRL PKEVSKEDKM IFVDEVMDLV ELDNLKDAIV GLPGVTGLST
1060 1070 1080 1090 1100
EQRKRLTIAV ELVANPSIIF MDEPTSGLDA RAAAIVMRTV RNTVDTGRTV
1110 1120 1130 1140 1150
VCTIHQPSID IFEAFDELLL MKRGGQVIYA GPLGRHSQKI IEYFEAIPGV
1160 1170 1180 1190 1200
QKIKEKYNPA TWMLEASSIG TEARLGMDFA EYYRSSALHQ RNKALVKELS
1210 1220 1230 1240 1250
APPPGAKDLY FTTQFSQPAW GQFKSCLWKQ WWTYWRSPDY NLVRFFFSLA
1260 1270 1280 1290 1300
AALLIGTIFW NVGSKRKSSG DLMTVIGAMY AAVLFVGINN CSTVQPIVAV
1310 1320 1330 1340 1350
ERTVFYRERA AGMYSALPYA MAQVFAEIPY ILVQTTYYTL IIYAMVGFEW
1360 1370 1380 1390 1400
TAAKFFWFYF VTFFSFLYWT YYGMMTVSIT PNHQVAAIFA AAFYALFNLF
1410 1420 1430 1440 1450
SGFFIPRPRI PKWWIWYYWI CPVAWTVYGS IVSQYGDVED TIQVPGVFPN
1460 1470 1480 1490
PRIKDYIKDH FGYSSDFMAP VAVVLVGFAA FFAFMYAYAI KTLNFQTR
Length:1,498
Mass (Da):169,614
Last modified:October 3, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9FD4E229624697E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JQ808000 mRNA Translation: AFN42936.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ808000 mRNA Translation: AFN42936.1

3D structure databases

SMRiI6XGC6
ModBaseiSearch...

Protein family/group databases

TCDBi3.A.1.205.24, the atp-binding cassette (abc) superfamily

Family and domain databases

CDDicd03233, ABCG_PDR_domain1, 1 hit
cd03232, ABCG_PDR_domain2, 1 hit
Gene3Di3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR029481, ABC_trans_N
IPR003439, ABC_transporter-like
IPR043926, ABCG_dom
IPR034001, ABCG_PDR_1
IPR034003, ABCG_PDR_2
IPR027417, P-loop_NTPase
IPR013581, PDR_assoc
PfamiView protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF19055, ABC2_membrane_7, 2 hits
PF00005, ABC_tran, 2 hits
PF14510, ABC_trans_N, 1 hit
PF08370, PDR_assoc, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI6XGC6_NICPL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I6XGC6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: September 29, 2021
This is version 32 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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