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Protein

RNA polymerase II transcription factor B subunit 2

Gene

EHEL_010530

Organism
Encephalitozoon hellem (strain ATCC 50504) (Microsporidian parasite)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
Ordered Locus Names:EHEL_010530Imported
OrganismiEncephalitozoon hellem (strain ATCC 50504) (Microsporidian parasite)Imported
Taxonomic identifieri907965 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000010086 Componenti: Chromosome I

Organism-specific databases

EuPathDBiMicrosporidiaDB:EHEL_010530

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi907965.XP_003886658.1

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3471 Eukaryota
COG5144 LUCA
KOiK03144
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

I6ULZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSEVSQTWP YPIDIVEYFG ELPRHSKAQL YGAPIFAVSF LKIFDEKTTR
60 70 80 90 100
FIFDLVLKSH SISSLREIEG IKEILKTLLR IEMIEKKGDN IYLDESLRRS
110 120 130 140 150
LMEGLCILTM EKHYKNTGKE LEIDEEESNR KFEAILKSIV NRECRIQAFG
160 170 180 190 200
IGEVLMFGGL LGKDRNITNR GFEFLLKTKK EQLWCLVLLS LKYFLGSVDE
210 220 230 240 250
EIHALEALFE LSTKAVGIAY HRTDRMDARL LKYLEALGIL KLYKESLAIG
260 270 280 290 300
KSFVQLFEAS ERNRREFIIV ETNNKIYAYT NSEYEKSVIH LFCSVSVNLP
310 320 330 340 350
NLIKGSITEE SVNVAFDKGI TGKQIIHFLE ASVKPGSLPP AISSQIMIWE
360 370 380 390 400
SKRNRIFMAP GYIYSNFLNL SDYQRVLEFC TERSYLIESD VDKRMIVVKV
410
EGHELVKEFI KTIL
Length:414
Mass (Da):47,796
Last modified:October 3, 2012 - v1
Checksum:i12DBBB1E59C1CBEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002713 Genomic DNA Translation: AFM97677.1
RefSeqiXP_003886658.1, XM_003886609.1

Genome annotation databases

EnsemblFungiiAFM97677; AFM97677; EHEL_010530
GeneIDi13466538
KEGGiehe:EHEL_010530

Similar proteinsi

Entry informationi

Entry nameiI6ULZ0_ENCHA
AccessioniPrimary (citable) accession number: I6ULZ0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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