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Protein

Neuraminidase

Gene

NA

Organism
Influenza A virus (A/mallard/Netherlands/11/1999(H2N9))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.UniRule annotationSAAS annotation

Cofactori

Ca2+UniRule annotationSAAS annotation

Activity regulationi

Inhibited by the neuraminidase inhibitors zanamivir (Relenza) and oseltamivir (Tamiflu). These drugs interfere with the release of progeny virus from infected cells and are effective against all influenza strains. Resistance to neuraminidase inhibitors is quite rare.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei119SubstrateUniRule annotation1
Active sitei152Proton donor/acceptorUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Binding sitei294SubstrateUniRule annotation1
Metal bindingi295Calcium; via carbonyl oxygenUniRule annotation1
Metal bindingi299Calcium; via carbonyl oxygenUniRule annotation1
Metal bindingi326CalciumUniRule annotation1
Metal bindingi348Calcium; via carbonyl oxygenUniRule annotation1
Binding sitei372SubstrateUniRule annotation1
Active sitei406NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotation, Hydrolase
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NeuraminidaseUniRule annotationSAAS annotation (EC:3.2.1.18UniRule annotationSAAS annotation)
Gene namesi
Name:NAUniRule annotationImported
OrganismiInfluenza A virus (A/mallard/Netherlands/11/1999(H2N9))Imported
Taxonomic identifieri1202605 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeAlphainfluenzavirus
Proteomesi
  • UP000142895 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 31HelicalUniRule annotationAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host membrane, Membrane, VirionUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi125 ↔ 130UniRule annotation
Disulfide bondi185 ↔ 232UniRule annotation
Disulfide bondi234 ↔ 239UniRule annotation
Disulfide bondi280 ↔ 293UniRule annotation
Disulfide bondi282 ↔ 291UniRule annotation

Post-translational modificationi

N-glycosylated.UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation, GlycoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 33Involved in apical transport and lipid raft associationUniRule annotationAdd BLAST23
Regioni92 – 470Head of neuraminidaseUniRule annotationAdd BLAST379
Regioni278 – 279Substrate bindingUniRule annotation2

Domaini

Intact N-terminus is essential for virion morphogenesis. Possess two apical sorting signals, one in the ectodomain, which is likely to be a glycan, and the other in the transmembrane domain. The transmembrane domain also plays a role in lipid raft association.UniRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 34 family.UniRule annotationSAAS annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd15483 Influenza_NA, 1 hit
HAMAPiMF_04071 INFV_NRAM, 1 hit
InterProiView protein in InterPro
IPR001860 Glyco_hydro_34
IPR033654 Sialidase_Influenza_A/B
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00064 Neur, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

I6TBS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPNQKILCT SATAIVIGTI AVLIGIANLG LNIGLHLKPS CNCSHSQPEA
60 70 80 90 100
TNASQTIINN YYNETNITQI SNTNIQMEER ASRGFNNLTK GLCTINSWHI
110 120 130 140 150
YGKDNAVRIG ENSDVLVTRE PYVSCDPDEC RFYALSQGTT IRGKHSNGTI
160 170 180 190 200
HDRSQYRALV SWPLSSPPTV YNSRVECIGW SSTSCHDGKS RMSICISGPN
210 220 230 240 250
NNASAVVWYN RRPVAEINTW ARNILRTQES ECVCHNGVCP VVFTDGSATG
260 270 280 290 300
PADTRIYYFK EGKILKWESL TGTAKHIEEC SCYGERTGIT CTCRDNWQGS
310 320 330 340 350
NRPVIQIDPV AMTHTSQYIC SPVLTDNPRP NDPNVGKCND PYPGNNNNGV
360 370 380 390 400
KGFSYLDGIN TWLGRTISTA SRSGYEMLKV PNALTDDRSK PIQGQTIVLN
410 420 430 440 450
TDWSGYSGSF MDYWAEGDCY RACFYVELIR GRPKEDKVWW TSNSIVSMCS
460 470
STEFLGQWNW PDGAKIEYFL
Length:470
Mass (Da):52,304
Last modified:October 3, 2012 - v1
Checksum:i6ED753E0EE3E28C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CY122246 Viral cRNA Translation: AFM83137.1

Similar proteinsi

Entry informationi

Entry nameiI6TBS8_9INFA
AccessioniPrimary (citable) accession number: I6TBS8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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