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Protein

Lipoate--protein ligase

Gene

EHR_00945

Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate.SAAS annotation

Pathwayi: protein lipoylation via exogenous pathway

This protein is involved in step 2 of the subpathway that synthesizes protein N(6)-(lipoyl)lysine from lipoate.SAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Lipoate--protein ligase (EHR_00945), Lipoate--protein ligase (EHR_13415)
This subpathway is part of the pathway protein lipoylation via exogenous pathway, which is itself part of Protein modification.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from lipoate, the pathway protein lipoylation via exogenous pathway and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseSAAS annotationImported, TransferaseImported
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciEHIR768486:GLCW-189-MONOMER
UniPathwayi
UPA00537;UER00595

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoate--protein ligaseSAAS annotation (EC:6.3.1.20SAAS annotation)
Gene namesi
Ordered Locus Names:EHR_00945Imported
ORF Names:I584_01616Imported
OrganismiEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)Imported
Taxonomic identifieri768486 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000002895 Componenti: Chromosome
  • UP000014142 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 209BPL/LPL catalyticInterPro annotationAdd BLAST184

Phylogenomic databases

KOiK03800
OrthoDBiPOG091H03KP

Family and domain databases

InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR019491 Lipoate_protein_ligase_C
IPR004562 LipoylTrfase_LipoateP_Ligase
PANTHERiPTHR12561 PTHR12561, 1 hit
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PF10437 Lip_prot_lig_C, 1 hit
TIGRFAMsiTIGR00545 lipoyltrans, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

I6S9L4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIFVPNDKHD PRINLAIEQF LLQEMPVDEP ILLFYINEPS IIIGRNQNTI
60 70 80 90 100
EEINRDYVEQ QGIHVVRRLS GGGAVYHDFG NLNFSFIMPD DGDSFRDFAK
110 120 130 140 150
VTKPIIQALH ELGVSGAELK GRNDLVIDGM KFSGNAMYAT NGRMFAHGTI
160 170 180 190 200
MFDSDINEVV NALKVKKDKI ESKGIKSIRS RVTNIKPFLP KERQEMLTEE
210 220 230 240 250
FRDEILLKIF GVATLAEVNT YQLTDKDWIK INEISDRYYR NWDWNYGKSP
260 270 280 290 300
DFNFSRQKRY PIGSIEVHLN VSHGLIDDVK IFGDFFGLGE IKDVEEKLIG
310 320 330
QRYDKSVLSD VVKTIDIKKY FGAIEAEDFL ALLY
Length:334
Mass (Da):38,387
Last modified:October 3, 2012 - v1
Checksum:i18824A51EA8E6F8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003504 Genomic DNA Translation: AFM69183.1
ASVZ01000002 Genomic DNA Translation: EOU05716.1
RefSeqiWP_010738270.1, NZ_KB946233.1

Genome annotation databases

EnsemblBacteriaiAFM69183; AFM69183; EHR_00945
EOU05716; EOU05716; I584_01616
GeneIDi13178975
KEGGiehr:EHR_00945
PATRICifig|768486.10.peg.2394

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003504 Genomic DNA Translation: AFM69183.1
ASVZ01000002 Genomic DNA Translation: EOU05716.1
RefSeqiWP_010738270.1, NZ_KB946233.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFM69183; AFM69183; EHR_00945
EOU05716; EOU05716; I584_01616
GeneIDi13178975
KEGGiehr:EHR_00945
PATRICifig|768486.10.peg.2394

Phylogenomic databases

KOiK03800
OrthoDBiPOG091H03KP

Enzyme and pathway databases

UniPathwayi
UPA00537;UER00595

BioCyciEHIR768486:GLCW-189-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR019491 Lipoate_protein_ligase_C
IPR004562 LipoylTrfase_LipoateP_Ligase
PANTHERiPTHR12561 PTHR12561, 1 hit
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PF10437 Lip_prot_lig_C, 1 hit
TIGRFAMsiTIGR00545 lipoyltrans, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI6S9L4_ENTHA
AccessioniPrimary (citable) accession number: I6S9L4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: February 28, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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