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Protein

Acetylornithine deacetylase

Gene

argE

Organism
Shigella flexneri 1235-66
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

N2-acetyl-L-ornithine + H2O = acetate + L-ornithine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Co2+SAAS annotation
  • glutathioneUniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear).SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetylornithine deacetylase (argE), Acetylornithine deacetylase (argE)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear), the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Cobalt or zinc 1UniRule annotation1
Active sitei82UniRule annotation1
Metal bindingi112Cobalt or zinc 1UniRule annotation1
Metal bindingi112Cobalt or zinc 2UniRule annotation1
Active sitei144UniRule annotation1
Metal bindingi145Cobalt or zinc 2UniRule annotation1
Metal bindingi169Cobalt or zinc 1UniRule annotation1
Metal bindingi355Cobalt or zinc 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation
LigandCobaltUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00110

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylaseUniRule annotation (EC:3.5.1.16UniRule annotation)
Short name:
AOUniRule annotation
Short name:
AcetylornithinaseUniRule annotation
Alternative name(s):
N-acetylornithinaseUniRule annotation
Short name:
NAOUniRule annotation
Gene namesi
Name:argEUniRule annotation
ORF Names:SF123566_6097Imported
OrganismiShigella flexneri 1235-66Imported
Taxonomic identifieri766154 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliI6G4Y8
SMRiI6G4Y8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 288M20_dimerInterPro annotationAdd BLAST111

Sequence similaritiesi

Belongs to the peptidase M20A family. ArgE subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

OMAiCAHQPGE

Family and domain databases

CDDicd03894 M20_ArgE, 1 hit
HAMAPiMF_01108 ArgE, 1 hit
InterProiView protein in InterPro
IPR010169 AcOrn-deacetyl
IPR001261 ArgE/DapE_CS
IPR036264 Bact_exopeptidase_dim_dom
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer
PANTHERiPTHR43808:SF1 PTHR43808:SF1, 1 hit
PfamiView protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit
SUPFAMiSSF55031 SSF55031, 1 hit
TIGRFAMsiTIGR01892 AcOrn-deacetyl, 1 hit
PROSITEiView protein in PROSITE
PS00758 ARGE_DAPE_CPG2_1, 1 hit
PS00759 ARGE_DAPE_CPG2_2, 1 hit

Sequencei

Sequence statusi: Complete.

I6G4Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKLPPFIE IYRALIATPS ISATEEALDQ SNADLITLLA DWFKDLGFNV
60 70 80 90 100
EVQPVPGTRN KFNMLASYGQ GAGGLLLAGH TDTVPFDDGR WTRDPFTLTE
110 120 130 140 150
HDGKLYGLGT ADMKGFFAFI LDALRDVDVT KLKKPLYILA TADEETSMAG
160 170 180 190 200
ARYFAETTAL RPDCAIIGEP TSLQPVRAHK GHISNAIRIQ GQSGHSSDPA
210 220 230 240 250
RGINAIELMH DAIGHILQLR DNLKERYHYE AFTVPYPTLN LGHIHGGDAS
260 270 280 290 300
NRICACCELH MDIRPQPGMT LNELNGLLND ALAPVSERWP GRLTVDELHP
310 320 330 340 350
PIPGYECPPN HQLVEVVEKL LGAKTEVVNY CTEAPFIQTL CPTLVLGPGS
360 370 380
INQAHQPDEY LETRFIKPTR ELIIQVIHHF CWH
Length:383
Mass (Da):42,438
Last modified:September 5, 2012 - v1
Checksum:iCA256DC0BEC4A7BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AKNF01001067 Genomic DNA Translation: EIQ63580.1

Genome annotation databases

EnsemblBacteriaiEIQ63580; EIQ63580; SF123566_6097
PATRICifig|766154.3.peg.7824

Entry informationi

Entry nameiI6G4Y8_SHIFL
AccessioniPrimary (citable) accession number: I6G4Y8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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