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Protein

RNA polymerase II transcription factor B subunit 2

Gene

WALSEDRAFT_18669

Organism
Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66) (Wallemia sebi (CBS 633.66))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:WALSEDRAFT_18669Imported
OrganismiWallemia mellicola (strain ATCC MYA-4683 / CBS 633.66) (Wallemia sebi (CBS 633.66))Imported
Taxonomic identifieri671144 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaWallemiomycotinaWallemiomycetesWallemialesWallemiaceaeWallemia
Proteomesi
  • UP000005242 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

InParanoidiI4YC35
KOiK03144
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

I4YC35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNELLVNYLK GLSKFNLNRL FNDKSSTLTI YRLLDDLNKQ IISSLLFSSK
60 70 80 90 100
LLDQSTLELL YKDADLVPLI ELNIIDNSNG SITLNEQFKH SLKQILIGRE
110 120 130 140 150
IESLSNSITT TIEQLDTFAT QQWELILHYM VGSYNSTPSK GVLFLLEKSN
160 170 180 190 200
LIYTANKQHR ISSKGFQFLL EDVQVQLWQL LLEYLSLSEI RQMDLVEVLS
210 220 230 240 250
FLFVLGTLEL GKDYSIESLT NTQQAMLSDL RDYGLVWQRK TSSKRFYPTR
260 270 280 290 300
LATTLTSSAP PLLPTTESSS FTTSSDNKRF IILETNYRLY AYTSNPLQIS
310 320 330 340 350
ILNLFVTLKA RYPNLVIGVI TRDSIRSALS NGITAEQIIG YLTSHAHTQM
360 370 380 390 400
HRNNPLLPVT VSDQIRLWEL EKNRLKADDG VLYAEFRSQP DYEILLNYAK
410 420 430 440
SYDCVLWSND IKRMFFVTLE GHQIVREFVR RRIPGNNNSS TSSQTPVSL
Length:449
Mass (Da):51,473
Last modified:September 5, 2012 - v1
Checksum:i4DF118DE07407F6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH668232 Genomic DNA Translation: EIM21527.1
RefSeqiXP_006958414.1, XM_006958352.1

Genome annotation databases

EnsemblFungiiEIM21527; EIM21527; WALSEDRAFT_18669
GeneIDi18470777
KEGGiwse:WALSEDRAFT_18669

Similar proteinsi

Entry informationi

Entry nameiI4YC35_WALMC
AccessioniPrimary (citable) accession number: I4YC35
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: July 18, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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