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Protein

dCTP deaminase

Gene

dcd

Organism
Desulfurococcus amylolyticus DSM 16532
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116dCTPUniRule annotation1
Active sitei126Proton donor/acceptorUniRule annotation1
Binding sitei158dCTPUniRule annotation1
Binding sitei161dCTPUniRule annotation1
Binding sitei165dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 105dCTP bindingUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processNucleotide metabolismUniRule annotation
LigandNucleotide-bindingUniRule annotation

Enzyme and pathway databases

BioCyciDFER768672:G1H0X-1253-MONOMER
UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
ORF Names:Desfe_1243Imported
OrganismiDesulfurococcus amylolyticus DSM 16532Imported
Taxonomic identifieri768672 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeDesulfurococcus
Proteomesi
  • UP000006175 Componenti: Chromosome

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI3XT38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 169dUTPaseInterPro annotationAdd BLAST99

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

KOiK01494
OrthoDBiPOG093Z0C6C

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

I3XT38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSDWDIRV YIEKKLLIID PLFEDTVREN GVDLRFGDEF CRFKKENSVV
60 70 80 90 100
DTSRDGVDNV LECYRVRGDG FVINPLEHVL TTTLEYVEFP HDLVGLVNLR
110 120 130 140 150
STFARFGLYI PPTVIDAGFK GNITIELVGS TVPVKVYPGQ RFLHLILART
160 170 180
SSPVYKPYTG KYQGQRGVTP PKLDNSPSKN L
Length:181
Mass (Da):20,523
Last modified:September 5, 2012 - v1
Checksum:i57AA97BCD4D23264
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003321 Genomic DNA Translation: AFL67112.1
RefSeqiWP_014768006.1, NC_018001.1

Genome annotation databases

EnsemblBacteriaiAFL67112; AFL67112; Desfe_1243
GeneIDi13061638
KEGGidfd:Desfe_1243

Similar proteinsi

Entry informationi

Entry nameiI3XT38_DESAM
AccessioniPrimary (citable) accession number: I3XT38
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: June 20, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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