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Protein

Insulin

Gene

INS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormoneUniRule annotationSAAS annotation
Biological processCarbohydrate metabolism, Glucose metabolismUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
InsulinUniRule annotation
Gene namesi
Name:INSImported
ORF Names:hCG_15480Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000254647.6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501430526525 – 110InsulinSequence analysisAdd BLAST86

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000254647 Expressed in 72 organ(s), highest expression level in type B pancreatic cell

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.UniRule annotationSAAS annotation

GO - Molecular functioni

Protein-protein interaction databases

IntActiI3WAC9, 2 interactors
I3WAC9, 2 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 109IlGFInterPro annotationAdd BLAST82

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
KOiK04526
OMAiGFFYSPK
OrthoDBiEOG091G0H56

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

I3WAC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPKTRREAED LQVGQVELGG GPGAGSLQPL ALEGSLQKRG IVEQCCTSIC
110
SLYQLENYCN
Length:110
Mass (Da):11,981
Last modified:September 5, 2012 - v1
Checksum:iC2C3B23B85E520E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ951950 mRNA Translation: AFK93533.1
CH471158 Genomic DNA Translation: EAX02489.1
RefSeqiNP_000198.1, NM_000207.2
NP_001172026.1, NM_001185097.1
NP_001172027.1, NM_001185098.1
NP_001278826.1, NM_001291897.1
UniGeneiHs.272259

Genome annotation databases

GeneIDi3630
KEGGihsa:3630

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ951950 mRNA Translation: AFK93533.1
CH471158 Genomic DNA Translation: EAX02489.1
RefSeqiNP_000198.1, NM_000207.2
NP_001172026.1, NM_001185097.1
NP_001172027.1, NM_001185098.1
NP_001278826.1, NM_001291897.1
UniGeneiHs.272259

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiI3WAC9, 2 interactors
I3WAC9, 2 interactors

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3630
KEGGihsa:3630

Organism-specific databases

CTDi3630
EuPathDBiHostDB:ENSG00000254647.6

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
KOiK04526
OMAiGFFYSPK
OrthoDBiEOG091G0H56

Miscellaneous databases

ChiTaRSiINS human
GenomeRNAii3630

Gene expression databases

BgeeiENSG00000254647 Expressed in 72 organ(s), highest expression level in type B pancreatic cell

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI3WAC9_HUMAN
AccessioniPrimary (citable) accession number: I3WAC9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: November 7, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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