UniProtKB - I3NI20 (I3NI20_HUMAN)
Protein
Submitted name:
Adenylate cyclase type 9
Gene
ADCY9
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- phosphorus-oxygen lyase activity Source: InterPro
GO - Biological processi
- cyclic nucleotide biosynthetic process Source: InterPro
- intracellular signal transduction Source: InterPro
Keywordsi
Molecular function | LyaseUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Adenylate cyclase type 9Imported |
Gene namesi | Name:ADCY9Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000162104.9 |
HGNCi | HGNC:240, ADCY9 |
PTM / Processingi
Proteomic databases
MaxQBi | I3NI20 |
PeptideAtlasi | I3NI20 |
PRIDEi | I3NI20 |
ProteomicsDBi | 47688 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162104, Expressed in secondary oocyte and 249 other tissues |
ExpressionAtlasi | I3NI20, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 49 | Guanylate cyclaseInterPro annotationAdd BLAST | 49 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 208 – 237 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 214 – 237 | PolarSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000155577 |
HOGENOMi | CLU_1083896_0_0_1 |
Family and domain databases
Gene3Di | 3.30.70.1230, 1 hit |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF00211, Guanylate_cyc, 1 hit |
SUPFAMi | SSF55073, SSF55073, 1 hit |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 1 hit PS50125, GUANYLATE_CYCLASE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
I3NI20-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
IEQFCQEKKE MVNMRVGVHT GTVLCGILGM RRFKFDVWSN DVNLANLMEQ
60 70 80 90 100
LGVAGKVHIS EATAKYLDDR YEMEDGKVIE RLGQSVVADQ LKGLKTYLIS
110 120 130 140 150
GQRAKESRCS CAEALLSGFE VIDGSQVSSG PRGQGTASSG NVSDLAQTVK
160 170 180 190 200
TFDNLKTCPS CGITFAPKSE AGAEGGAPQN GCQDEHKNST KVTSSWLLFL
210 220 230 240 250
SVPLLAHPPK ASGGPNPKTQ NGLLSPPQEE KLTNSQTSLC EILQEKGRWA
GVSLDQS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO60503 | ADCY9_HUMAN | Adenylate cyclase type 9 | ADCY9 KIAA0520 | 1,353 | Annotation score: | ||
I3L300 | I3L300_HUMAN | Adenylate cyclase type 9 | ADCY9 | 215 | Annotation score: | ||
I3L342 | I3L342_HUMAN | Adenylate cyclase type 9 | ADCY9 | 72 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 257 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005736 Genomic DNA No translation available. KF454950 Genomic DNA No translation available. KF456147 Genomic DNA No translation available. KF456149 Genomic DNA No translation available. KF456154 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000572288; ENSP00000461825; ENSG00000162104 |
UCSCi | uc059qcg.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005736 Genomic DNA No translation available. KF454950 Genomic DNA No translation available. KF456147 Genomic DNA No translation available. KF456149 Genomic DNA No translation available. KF456154 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | I3NI20 |
PeptideAtlasi | I3NI20 |
PRIDEi | I3NI20 |
ProteomicsDBi | 47688 |
Protocols and materials databases
Antibodypediai | 55436, 223 antibodies |
Genome annotation databases
Ensembli | ENST00000572288; ENSP00000461825; ENSG00000162104 |
UCSCi | uc059qcg.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000162104.9 |
HGNCi | HGNC:240, ADCY9 |
OpenTargetsi | ENSG00000162104 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155577 |
HOGENOMi | CLU_1083896_0_0_1 |
Miscellaneous databases
ChiTaRSi | ADCY9, human |
Gene expression databases
Bgeei | ENSG00000162104, Expressed in secondary oocyte and 249 other tissues |
ExpressionAtlasi | I3NI20, baseline and differential |
Family and domain databases
Gene3Di | 3.30.70.1230, 1 hit |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF00211, Guanylate_cyc, 1 hit |
SUPFAMi | SSF55073, SSF55073, 1 hit |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 1 hit PS50125, GUANYLATE_CYCLASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I3NI20_HUMAN | |
Accessioni | I3NI20Primary (citable) accession number: I3NI20 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | July 11, 2012 | |
Last modified: | August 12, 2020 | |
This is version 42 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |