UniProtKB - I3NDY8 (I3NDY8_ICTTR)
Protein
Fork-head domain-containing protein
Gene
FOXO4
Organism
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 101 – 195 | Fork-headPROSITE-ProRule annotationAdd BLAST | 95 |
GO - Molecular functioni
- beta-catenin binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- enzyme binding Source: Ensembl
- identical protein binding Source: Ensembl
- sequence-specific double-stranded DNA binding Source: Ensembl
- transcription factor binding Source: Ensembl
GO - Biological processi
- cell cycle arrest Source: Ensembl
- insulin receptor signaling pathway Source: Ensembl
- mitotic G2 DNA damage checkpoint Source: Ensembl
- negative regulation of angiogenesis Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of G0 to G1 transition Source: Ensembl
- negative regulation of smooth muscle cell differentiation Source: Ensembl
- positive regulation of cell cycle arrest Source: Ensembl
- stem cell differentiation Source: Ensembl
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Fork-head domain-containing proteinInterPro annotation |
Gene namesi | Name:FOXO4Imported |
Organismi | Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)Imported |
Taxonomic identifieri | 43179 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciuromorpha › Sciuridae › Xerinae › Marmotini › Ictidomys |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Cytosol
- cytosol Source: Ensembl
Nucleus
- nuclear speck Source: Ensembl
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationInteractioni
GO - Molecular functioni
- beta-catenin binding Source: Ensembl
- enzyme binding Source: Ensembl
- identical protein binding Source: Ensembl
- transcription factor binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 43179.ENSSTOP00000022585 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 101 – 195 | Fork-headInterPro annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 100 | DisorderedSequence analysisAdd BLAST | 100 | |
Regioni | 176 – 244 | DisorderedSequence analysisAdd BLAST | 69 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 31 – 47 | Pro-richSequence analysisAdd BLAST | 17 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000159334 |
HOGENOMi | CLU_023456_1_1_1 |
InParanoidi | I3NDY8 |
OMAi | VHTEGHS |
OrthoDBi | 1160384at2759 |
TreeFami | TF315583 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032067, FOXO-TAD IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16676, FOXO-TAD, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
i Sequence
Sequence statusi: Complete.
I3NDY8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPGNKNSAT EAAAIIDLDP DFEPQSRPRS CTWPLPRPEP TTKPSEPPEV
60 70 80 90 100
EPGLGEKVHT EGHSEPILLP SRLPEPAGGP QPGILGAVTG PRKGGSRRNA
110 120 130 140 150
WGNQSYAELI SQAIESAPEK RLTLAQIYEW MVRTVPYFKD KGDSNSSAGW
160 170 180 190 200
KNSIRHNLSL HSKFIKVHNE ATGKSSWWML NPEGGKSGKA PRRRAASMDS
210 220 230 240 250
SSKLLRGRSK APKKKPSVLP APPEGATPTS PIGHFSKWSG SPCSRNREEA
260 270 280 290 300
DMWTAFRPRS SSNASTVSTR LSPMRPESEV LAEEEIPASV SSYAGGVPPT
310 320 330 340 350
LNEDLELLDG LNLTSPHSLL SRSSLSGFSL QHPGVPGPLH TYGASLFGPA
360 370 380 390 400
EGPMSAEGCF SSSQSLEALL TSDTPPPPAD VLMTQVDPIL SQAPTLLLLG
410 420 430 440 450
GMPSSSKLAT GVGLCPKPLE APGPSSLVPT LPMMAPPPVM GGAPIPKALG
460 470 480 490 500
TPVLTPPTEA SSQDRMPQDL DLDMYMENLE CDMDNIISDL MDGGEGLDFN
FEPDP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AGTP01104263 Genomic DNA No translation available. |
RefSeqi | XP_005340026.1, XM_005339969.2 |
Genome annotation databases
Ensembli | ENSSTOT00000014587; ENSSTOP00000022585; ENSSTOG00000014587 |
GeneIDi | 101962162 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AGTP01104263 Genomic DNA No translation available. |
RefSeqi | XP_005340026.1, XM_005339969.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 43179.ENSSTOP00000022585 |
Genome annotation databases
Ensembli | ENSSTOT00000014587; ENSSTOP00000022585; ENSSTOG00000014587 |
GeneIDi | 101962162 |
Organism-specific databases
CTDi | 4303 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000159334 |
HOGENOMi | CLU_023456_1_1_1 |
InParanoidi | I3NDY8 |
OMAi | VHTEGHS |
OrthoDBi | 1160384at2759 |
TreeFami | TF315583 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032067, FOXO-TAD IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16676, FOXO-TAD, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I3NDY8_ICTTR | |
Accessioni | I3NDY8Primary (citable) accession number: I3NDY8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | July 11, 2012 | |
Last modified: | October 7, 2020 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |