UniProtKB - I3NDD8 (I3NDD8_ICTTR)
Protein
Paired domain-containing protein
Gene
PAX5
Organism
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- adult behavior Source: Ensembl
- aging Source: Ensembl
- cerebral cortex development Source: Ensembl
- embryonic cranial skeleton morphogenesis Source: Ensembl
- lateral ventricle development Source: Ensembl
- negative regulation of histone H3-K9 methylation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- skeletal muscle cell differentiation Source: Ensembl
Keywordsi
Molecular function | Developmental proteinARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Paired domain-containing proteinInterPro annotation |
Gene namesi | Name:PAX5Imported |
Organismi | Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)Imported |
Taxonomic identifieri | 43179 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciuromorpha › Sciuridae › Xerinae › Marmotini › Ictidomys |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: Ensembl
Nucleus
- fibrillar center Source: Ensembl
- nucleoplasm Source: Ensembl
Keywords - Cellular componenti
NucleusARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 142 | PairedInterPro annotationAdd BLAST | 127 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 182 – 218 | DisorderedSequence analysisAdd BLAST | 37 |
Keywords - Domaini
Paired boxARBA annotationPhylogenomic databases
eggNOGi | KOG3862, Eukaryota |
GeneTreei | ENSGT00940000159636 |
HOGENOMi | CLU_019281_4_0_1 |
InParanoidi | I3NDD8 |
OMAi | QPSCPIQ |
TreeFami | TF315397 |
Family and domain databases
CDDi | cd00131, PAX, 1 hit |
Gene3Di | 1.10.10.10, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR043182, PAIRED_DNA-bd_dom IPR001523, Paired_dom IPR022130, Pax2_C IPR043565, PAX_fam IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR45636, PTHR45636, 1 hit |
Pfami | View protein in Pfam PF00292, PAX, 1 hit PF12403, Pax2_C, 1 hit |
PRINTSi | PR00027, PAIREDBOX |
SMARTi | View protein in SMART SM00351, PAX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00034, PAIRED_1, 1 hit PS51057, PAIRED_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
I3NDD8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLEKNYPTP RTGRTGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR
60 70 80 90 100
PCDISRQLRV SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVEKIA
110 120 130 140 150
EYKRQNPTMF AWEIRDRLLA ERVCDNDTVP SVSSINRIIR TKVQQPPNQP
160 170 180 190 200
VPASSHSIVS TGSVTQVSSV STDSAGSSYS ISGILGITSP SADTNKRKRD
210 220 230 240 250
EGIQDSPVPN GHSLPGRDFL RKQMRGDLFT QQQLEVLDRV FERQHYSDIF
260 270 280 290 300
TTTEPIKPEQ TTEYSAMASL AGGLDDMKAN LTSPTPADIG SSVPGPQSYP
310 320 330 340 350
IVTGRDLAST TLPGYPPHVP PAGQGSYSAP TLTGMVPGSE FSGSPYSHPQ
360 370 380 390
YSSYNDSWRF PNPGLLGSPY YYSAAARGAA PPAAATAYDR H
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A287D9I7 | A0A287D9I7_ICTTR | Paired domain-containing protein | PAX5 | 348 | Annotation score: | ||
A0A287DDF7 | A0A287DDF7_ICTTR | Paired domain-containing protein | PAX5 | 293 | Annotation score: | ||
A0A287D3V2 | A0A287D3V2_ICTTR | Paired domain-containing protein | PAX5 | 328 | Annotation score: | ||
A0A287CZ53 | A0A287CZ53_ICTTR | Paired domain-containing protein | PAX5 | 357 | Annotation score: | ||
A0A287D5V2 | A0A287D5V2_ICTTR | Paired domain-containing protein | PAX5 | 327 | Annotation score: | ||
A0A287DFY2 | A0A287DFY2_ICTTR | Paired domain-containing protein | PAX5 | 362 | Annotation score: | ||
A0A287DB61 | A0A287DB61_ICTTR | Paired domain-containing protein | PAX5 | 291 | Annotation score: | ||
A0A287D837 | A0A287D837_ICTTR | Paired domain-containing protein | PAX5 | 107 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AGTP01043650 Genomic DNA No translation available. AGTP01043651 Genomic DNA No translation available. AGTP01043652 Genomic DNA No translation available. AGTP01043653 Genomic DNA No translation available. |
RefSeqi | XP_005326343.1, XM_005326286.1 |
Genome annotation databases
Ensembli | ENSSTOT00000028985; ENSSTOP00000022385; ENSSTOG00000024354 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AGTP01043650 Genomic DNA No translation available. AGTP01043651 Genomic DNA No translation available. AGTP01043652 Genomic DNA No translation available. AGTP01043653 Genomic DNA No translation available. |
RefSeqi | XP_005326343.1, XM_005326286.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 43179.ENSSTOP00000022385 |
Genome annotation databases
Ensembli | ENSSTOT00000028985; ENSSTOP00000022385; ENSSTOG00000024354 |
Phylogenomic databases
eggNOGi | KOG3862, Eukaryota |
GeneTreei | ENSGT00940000159636 |
HOGENOMi | CLU_019281_4_0_1 |
InParanoidi | I3NDD8 |
OMAi | QPSCPIQ |
TreeFami | TF315397 |
Family and domain databases
CDDi | cd00131, PAX, 1 hit |
Gene3Di | 1.10.10.10, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR043182, PAIRED_DNA-bd_dom IPR001523, Paired_dom IPR022130, Pax2_C IPR043565, PAX_fam IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR45636, PTHR45636, 1 hit |
Pfami | View protein in Pfam PF00292, PAX, 1 hit PF12403, Pax2_C, 1 hit |
PRINTSi | PR00027, PAIREDBOX |
SMARTi | View protein in SMART SM00351, PAX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00034, PAIRED_1, 1 hit PS51057, PAIRED_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I3NDD8_ICTTR | |
Accessioni | I3NDD8Primary (citable) accession number: I3NDD8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | July 11, 2012 | |
Last modified: | February 10, 2021 | |
This is version 54 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |