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Entry version 43 (07 Oct 2020)
Sequence version 2 (22 Nov 2017)
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Protein
Submitted name:

Uncharacterized protein

Gene

ANK2

Organism
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri43179 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciuromorphaSciuridaeXerinaeMarmotiniIctidomys
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005215 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 769ANK_REP_REGIONInterPro annotationAdd BLAST751
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati52 – 84ANKPROSITE-ProRule annotationAdd BLAST33
Repeati85 – 117ANKPROSITE-ProRule annotationAdd BLAST33
Repeati118 – 150ANKPROSITE-ProRule annotationAdd BLAST33
Repeati221 – 253ANKPROSITE-ProRule annotationAdd BLAST33
Repeati254 – 286ANKPROSITE-ProRule annotationAdd BLAST33
Repeati287 – 319ANKPROSITE-ProRule annotationAdd BLAST33
Repeati320 – 352ANKPROSITE-ProRule annotationAdd BLAST33
Repeati353 – 385ANKPROSITE-ProRule annotationAdd BLAST33
Repeati386 – 418ANKPROSITE-ProRule annotationAdd BLAST33
Repeati419 – 451ANKPROSITE-ProRule annotationAdd BLAST33
Repeati452 – 484ANKPROSITE-ProRule annotationAdd BLAST33
Repeati485 – 517ANKPROSITE-ProRule annotationAdd BLAST33
Repeati518 – 550ANKPROSITE-ProRule annotationAdd BLAST33
Repeati551 – 583ANKPROSITE-ProRule annotationAdd BLAST33
Repeati584 – 616ANKPROSITE-ProRule annotationAdd BLAST33
Repeati617 – 649ANKPROSITE-ProRule annotationAdd BLAST33
Repeati650 – 682ANKPROSITE-ProRule annotationAdd BLAST33
Repeati683 – 715ANKPROSITE-ProRule annotationAdd BLAST33
Repeati716 – 748ANKPROSITE-ProRule annotationAdd BLAST33
Domaini924 – 1079ZU5InterPro annotationAdd BLAST156
Domaini1081 – 1227ZU5InterPro annotationAdd BLAST147
Domaini3412 – 3496DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1562 – 2033DisorderedSequence analysisAdd BLAST472
Regioni2097 – 2298DisorderedSequence analysisAdd BLAST202
Regioni2317 – 2396DisorderedSequence analysisAdd BLAST80
Regioni2414 – 2751DisorderedSequence analysisAdd BLAST338
Regioni2776 – 2805DisorderedSequence analysisAdd BLAST30
Regioni2819 – 2865DisorderedSequence analysisAdd BLAST47
Regioni2911 – 2942DisorderedSequence analysisAdd BLAST32
Regioni2979 – 3025DisorderedSequence analysisAdd BLAST47
Regioni3057 – 3304DisorderedSequence analysisAdd BLAST248
Regioni3529 – 3714DisorderedSequence analysisAdd BLAST186
Regioni3823 – 3852DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3321 – 3341Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1570 – 1606PolyampholyteSequence analysisAdd BLAST37
Compositional biasi1624 – 1651PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1678 – 1717PolyampholyteSequence analysisAdd BLAST40
Compositional biasi1718 – 1805PolarSequence analysisAdd BLAST88
Compositional biasi1871 – 1885PolarSequence analysisAdd BLAST15
Compositional biasi1908 – 1942PolyampholyteSequence analysisAdd BLAST35
Compositional biasi1943 – 1958PolarSequence analysisAdd BLAST16
Compositional biasi1973 – 2023PolyampholyteSequence analysisAdd BLAST51
Compositional biasi2129 – 2159PolyampholyteSequence analysisAdd BLAST31
Compositional biasi2161 – 2176PolarSequence analysisAdd BLAST16
Compositional biasi2196 – 2210PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2211 – 2230PolarSequence analysisAdd BLAST20
Compositional biasi2330 – 2357PolarSequence analysisAdd BLAST28
Compositional biasi2375 – 2396PolyampholyteSequence analysisAdd BLAST22
Compositional biasi2414 – 2433PolyampholyteSequence analysisAdd BLAST20
Compositional biasi2441 – 2482PolyampholyteSequence analysisAdd BLAST42
Compositional biasi2494 – 2510PolarSequence analysisAdd BLAST17
Compositional biasi2534 – 2566PolarSequence analysisAdd BLAST33
Compositional biasi2576 – 2618PolyampholyteSequence analysisAdd BLAST43
Compositional biasi2626 – 2647PolarSequence analysisAdd BLAST22
Compositional biasi2648 – 2671PolyampholyteSequence analysisAdd BLAST24
Compositional biasi2733 – 2750PolarSequence analysisAdd BLAST18
Compositional biasi2844 – 2859PolarSequence analysisAdd BLAST16
Compositional biasi2914 – 2942PolarSequence analysisAdd BLAST29
Compositional biasi2998 – 3012PolarSequence analysisAdd BLAST15
Compositional biasi3073 – 3106PolarSequence analysisAdd BLAST34
Compositional biasi3107 – 3122PolyampholyteSequence analysisAdd BLAST16
Compositional biasi3136 – 3150PolarSequence analysisAdd BLAST15
Compositional biasi3203 – 3233PolarSequence analysisAdd BLAST31
Compositional biasi3234 – 3258PolyampholyteSequence analysisAdd BLAST25
Compositional biasi3286 – 3301PolarSequence analysisAdd BLAST16
Compositional biasi3532 – 3554PolyampholyteSequence analysisAdd BLAST23
Compositional biasi3561 – 3634PolarSequence analysisAdd BLAST74
Compositional biasi3641 – 3657PolarSequence analysisAdd BLAST17
Compositional biasi3690 – 3711PolyampholyteSequence analysisAdd BLAST22

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155279

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 22 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 19 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

I3N7W6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSLYPSLTE VFSSTPQSDS NASFLRAARA GNLDKVVEYL KGGIDINTCN
60 70 80 90 100
QNGLNALHLA AKEGHVGLVQ ELLGRGSSVD SATKKGNTAL HIASLAGQAE
110 120 130 140 150
VVKVLVKEGA NINAQSQNGF TPLYMAAQEN HIDVVKYLLE NGANQSTATE
160 170 180 190 200
DGFTPLAVAL QQGHNQAVAI LLENDTKGKV RLPALHIAAR KDDTKSAALL
210 220 230 240 250
LQNDHNADVQ SKMMVNRTTE SGFTPLHIAA HYGNVNVATL LLNRGAAVDF
260 270 280 290 300
TARNGITPLH VASKRGNTNM VKLLLDRGGQ IDAKTRDGLT PLHCAARSGH
310 320 330 340 350
DQVVELLLER GAPLLARTKN GLSPLHMAAQ GDHVECVKHL LQHKAPVDDV
360 370 380 390 400
TLDYLTALHV AAHCGHYRVT KLLLDKRANP NARALNGFTP LHIACKKNRI
410 420 430 440 450
KVMELLVKYG ASIQAITESG LTPIHVAAFM GHLNIVLLLL QNGASPDVTN
460 470 480 490 500
IRGETALHMA ARAGQVEVVR CLLRNGALVD ARAREEQTPL HIASRLGKTE
510 520 530 540 550
IVQLLLQHMA HPDAATTNGY TPLHISAREG QVDVASVLLE AGAVHSLATK
560 570 580 590 600
KGFTPLHVAA KYGSLDVAKL LLQRRAAADS AGKNGYTPLH IAAKKNQMQI
610 620 630 640 650
ASTLLNYGAE TNIVTKQGVT PLHLASQEGH TDMVTLLLEK GANIHMSTKS
660 670 680 690 700
GLTSLHLAAQ EDKVNVAEIL TKHGADQDAH TKLGYTPLIV ACHYGNVKMV
710 720 730 740 750
NFLLKQGANV NAKTKNGYTP LHQAAQQGHT HIINVLLQHG AKPNATTANG
760 770 780 790 800
NTALAIAKRL GYISVVDTLK VVTEEVTTTT TTITEKHKLN VPETMTEVLD
810 820 830 840 850
VSDEEGDDTM TGDGGEYLRP EDLKELGDDS LPSSQFLDGM NYLRYSLEGG
860 870 880 890 900
RSDSLRSFSS DRSHTLSHAS YLRDSAMIDD TVVIPSHQVS TLAKEAERNS
910 920 930 940 950
YRLSWGTENL DNVALSSSPI HSGFLVSFMV DARGGAMRGC RHNGLRIIIP
960 970 980 990 1000
PRKCTAPTRV TCRLVKRHRL ATMPPMVEGE GLASRLIEVG PSGAQFLGPV
1010 1020 1030 1040 1050
IVEIPHFAAL RGKERELVVL RSENGDSWKE HFCEYTEDEL NEILNGMDEV
1060 1070 1080 1090 1100
LDSPEDLEKK RICRIITRDF PQYFAVVSRI KQDSNLIGPE GGVLSSTVVP
1110 1120 1130 1140 1150
QVQAVFPEGA LTKRIRVGLQ AQPMHSELVK KILGNKATFS PIVTLEPRRR
1160 1170 1180 1190 1200
KFHKPITMTI PVPKASSDVM LNGFGGDAPT LRLLCSITGG TTPAQWEDIT
1210 1220 1230 1240 1250
GTTPLTFVNE CVSFTTNVSA RFWLIDCRQI QESVTFASQV YREIICVPYM
1260 1270 1280 1290 1300
AKFVVFAKSH DPIEARLRCF CMTDDKVDKT LEQQENFAEV ARSRDVEVLE
1310 1320 1330 1340 1350
GKPIYVDCFG NLVPLTKSGQ HHIFSFFAFK ENRLPLFVKV RDTTQEPCGR
1360 1370 1380 1390 1400
LSFMKEPKST RGLVHQAICN LNITLPIYMK ESESDQEQEE ETESTETSVL
1410 1420 1430 1440 1450
KSHLVNEVPV LASPDLLSEV SEMKQDLIKM TAILTTDVSD KAGSIKVKEL
1460 1470 1480 1490 1500
VKAAEEEPGE PFEIVERVKE DLEKVNEILR SGTCSREESS VQSSAQSEKE
1510 1520 1530 1540 1550
LVEEGWVIVS DEEIEEARQK APLEITEYPC VEVRLEKETK AQVEKDATGL
1560 1570 1580 1590 1600
VNYLVEDLNS YVSPHGEKPQ TGHDVAREKS EAPSVGKSSE KEGKAAPPDE
1610 1620 1630 1640 1650
KQGLQKPHKP TLGIKKPVRR KLKEKQKQKE ESINASEDKS EVKKGSSEES
1660 1670 1680 1690 1700
LDEDAGLAPE SLPTVKATSP LIEETPIGSI KDKVKALQKR VEDEQKGRSK
1710 1720 1730 1740 1750
LPIRVKGKED VPKKTTHRTH PTASPSLKTD RHSPLSSSAK NERHPPVSPS
1760 1770 1780 1790 1800
SKTEKHSPVS PSAKTERHSP VLSSGKTEKH SPVSPSTKAE RHSPVSSTKT
1810 1820 1830 1840 1850
ERHPPVSPST KTDKRPPVSP SGRTEKHPPV SPGRTEKRLP VSPSGRTEKH
1860 1870 1880 1890 1900
PPVSTAAKTE KHLPVSPSGK TEKQPPVSPT SKTERIEETM SVRELMKAFQ
1910 1920 1930 1940 1950
SGQDPSKHKT GLFEHKSAKQ KPSQEKGKAA RVEKEKGQTA TLKETQRTET
1960 1970 1980 1990 2000
QTIKRGQRFL VTGASESRRG VRTSSIGFKK EDAVGEKEKA PSPKTPEPVH
2010 2020 2030 2040 2050
SAPEEESHRE KKMVDEQGDM DLQISPDRKT STDFSDVIKQ ELEDNDKYQQ
2060 2070 2080 2090 2100
FRMSEGTEKA QLHLDQVLTS PFNTTFPLDY MKDEFLPALS LQSDALDASS
2110 2120 2130 2140 2150
ESLKQEGMAG SPCGSLMEGT PQISSEESYK HEGLAETPET SPEREEHHPT
2160 2170 2180 2190 2200
KDITDEPSKD ISPQPEGSSS VSLAKETPKA LTDEGQLTLD SSAHKTPTDG
2210 2220 2230 2240 2250
EARESPDETK SSPLTDASVK TDTGIASKPQ GGMRSPQGLE LALPSRDSEV
2260 2270 2280 2290 2300
LSPMADESLA TPDSLEPSPL KESPCRDSLE SSPVEPKMKA GILPSHFPLP
2310 2320 2330 2340 2350
SAVTKTELVT EVASMRSRLL RDPDGSAEDD SLEQTSLMES SGKSPLSPDT
2360 2370 2380 2390 2400
PSSEEVSYEV TPKAADTSTP KPAVIHECAE EDDSENGEKK RFTPEEEMFK
2410 2420 2430 2440 2450
MVTKIKMFDE LEQEAKQKRD YKKEPKQEES SSSSDPDADC SADVDEPKQV
2460 2470 2480 2490 2500
DEPKQVDEPK QVDEPKQVDE PKQVDEPKQM ENMAGESHVP VLVTSESRKA
2510 2520 2530 2540 2550
SSSSDSEPEL TQLKKGADSG LLPEPVIRVQ PPSPLPSSID SNSSPEEVQF
2560 2570 2580 2590 2600
QPIVSKQYTF KMNEDTQEEP GNSEEEKDCE SPLADDSHPF STDDADRTYD
2610 2620 2630 2640 2650
ADRTYDDLSR DTDQPKVCDG HGCEAVSPTC STTPISSGLQ NSAGDDVDEQ
2660 2670 2680 2690 2700
LVTHKESFAP QDTHENDPGE ELDAPAVESP QRECPSDSYS SLSPLPHCPE
2710 2720 2730 2740 2750
SEGKELDDDL SSTSSTTKVE VTKTDETLEN IPKDYSTQDS SITTQTDRFP
2760 2770 2780 2790 2800
MDVPVSDLAE TGEIYDPHVI SPYENVPTQS FFSSEESKTQ TGTSHTSSDY
2810 2820 2830 2840 2850
SSEVYSVTTS SVEDVLVTSS SSATVSSKES NLEGQHLEIE SRQESTLWEM
2860 2870 2880 2890 2900
QSDRASSLEP GVPSTPAVIS EQISKVIITK TDVDSDSWSE IREDDEAFEA
2910 2920 2930 2940 2950
RVKEEEQKIF GLMVDRQSQG TTPDTTPART PTEEGTPTSE QNPFLFQEGK
2960 2970 2980 2990 3000
LFEMTRSGAI DMTKRSYADE SFHFFQIGQE SRDDTLSEDM KEGVTGAEPQ
3010 3020 3030 3040 3050
QLESTAESLA LSESKETVDD EGELLPDDLS EEVEEISASD THLNSQMGIS
3060 3070 3080 3090 3100
VCMEPSTKEA IATGAEDLPT MQRGDTPSPS NVKQTPCSDS PEPVVQVQLD
3110 3120 3130 3140 3150
FSTVTRSVYS DRDDDSPDSS PEEQKSVIEI PTAPMENVPS TESKSKIPVR
3160 3170 3180 3190 3200
TIPTSIPEPP SVEDESTFSE DVLSSLDEES KEDEAKPKSK IPIKAPIQRV
3210 3220 3230 3240 3250
EQSLSHLGAS LQQSVAPQGQ DVTSRTPDNR SQSESDVSPE DSKTKCPVKA
3260 3270 3280 3290 3300
RSDTETETES REGAEELELE SEEGATGPKI FASRLPVKSR STTSSCRGGM
3310 3320 3330 3340 3350
SPTKESKEHF FDLYRNSIEF FEEISDEASK LVDRLTQSER EQELVSDDES
3360 3370 3380 3390 3400
SSALEVSVIE NLPPVETEHS VPEDIFDTRP IWDESIETLI ERIPDENGHD
3410 3420 3430 3440 3450
HAEDPQDEQE RIEERLAYIA DHLGFSWTEL ARELDFTEEQ IHQIRIENPN
3460 3470 3480 3490 3500
SLQDQSHALL KYWLERDGKH ATDTNLIECL TKINRMDIVH LMETSTEPLQ
3510 3520 3530 3540 3550
ERISHSYAEI EQTITLDHSE GFSVLQEELS AAQHKQSEEQ ALSKESESSD
3560 3570 3580 3590 3600
HPPIVSEEDI SVGYSTFQDS IPKTEGDSAT TVLSPQTHKE QVQQDFSGKM
3610 3620 3630 3640 3650
QDLPEDNVTT PGTEGSETHK ATAEPGSPSK TPEEISTPPE EERQYLQTPT
3660 3670 3680 3690 3700
SSERGGSPIV QEPEELPEPR EEGSPRKTSL VIVESADDQA QTVERLDGDA
3710 3720 3730 3740 3750
TFDKGDDMPD IPPETVTEEE YIDEHGHTVV KKVTRKIIRR YVSSDGTEKE
3760 3770 3780 3790 3800
EITMQGMPQE PVTIQEGDGY SKVIKRVVLK SDIEQSEVTL SEPSILSSAS
3810 3820 3830 3840 3850
QFQAEPVEGR RVSKVIKTTM VRGERMEKHL GDSSLATDLP SAKDDFEEDN

HE
Length:3,852
Mass (Da):422,794
Last modified:November 22, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30BC1947815E4530
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3LZ16I3LZ16_ICTTR
Uncharacterized protein
ANK2
3,860Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A287D8I3A0A287D8I3_ICTTR
Uncharacterized protein
ANK2
4,065Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A287CUW1A0A287CUW1_ICTTR
Uncharacterized protein
ANK2
4,107Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A287D6G0A0A287D6G0_ICTTR
Uncharacterized protein
ANK2
4,083Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3N5D5I3N5D5_ICTTR
Uncharacterized protein
ANK2
4,109Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A287DC56A0A287DC56_ICTTR
ANK_REP_REGION domain-containing pr...
ANK2
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A287CU44A0A287CU44_ICTTR
Uncharacterized protein
ANK2
1,057Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A287CXT5A0A287CXT5_ICTTR
Uncharacterized protein
ANK2
1,219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A287DG06A0A287DG06_ICTTR
Uncharacterized protein
ANK2
1,114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AGTP01060620 Genomic DNA No translation available.
AGTP01060621 Genomic DNA No translation available.
AGTP01060622 Genomic DNA No translation available.
AGTP01060623 Genomic DNA No translation available.
AGTP01060624 Genomic DNA No translation available.
AGTP01060625 Genomic DNA No translation available.
AGTP01060626 Genomic DNA No translation available.
AGTP01060627 Genomic DNA No translation available.
AGTP01060628 Genomic DNA No translation available.
AGTP01060629 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSTOT00000025842; ENSSTOP00000020462; ENSSTOG00000001648

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGTP01060620 Genomic DNA No translation available.
AGTP01060621 Genomic DNA No translation available.
AGTP01060622 Genomic DNA No translation available.
AGTP01060623 Genomic DNA No translation available.
AGTP01060624 Genomic DNA No translation available.
AGTP01060625 Genomic DNA No translation available.
AGTP01060626 Genomic DNA No translation available.
AGTP01060627 Genomic DNA No translation available.
AGTP01060628 Genomic DNA No translation available.
AGTP01060629 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSSTOT00000025842; ENSSTOP00000020462; ENSSTOG00000001648

Phylogenomic databases

GeneTreeiENSGT00940000155279

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 22 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 19 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3N7W6_ICTTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3N7W6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: November 22, 2017
Last modified: October 7, 2020
This is version 43 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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