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Entry version 47 (12 Aug 2020)
Sequence version 2 (22 Nov 2017)
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Protein
Submitted name:

Uncharacterized protein

Gene

TNRC6A

Organism
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRNA-mediated gene silencingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC6AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri43179 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciuromorphaSciuridaeXerinaeMarmotiniIctidomys
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005215 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1101 – 1218Ago_hookInterPro annotationAdd BLAST118
Domaini1297 – 1498M_domainInterPro annotationAdd BLAST202
Domaini1522 – 1795TNRC6-PABC_bdgInterPro annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni32 – 180DisorderedSequence analysisAdd BLAST149
Regioni204 – 252DisorderedSequence analysisAdd BLAST49
Regioni267 – 322DisorderedSequence analysisAdd BLAST56
Regioni463 – 482DisorderedSequence analysisAdd BLAST20
Regioni587 – 726DisorderedSequence analysisAdd BLAST140
Regioni744 – 1157DisorderedSequence analysisAdd BLAST414
Regioni1266 – 1289DisorderedSequence analysisAdd BLAST24
Regioni1340 – 1385DisorderedSequence analysisAdd BLAST46
Regioni1441 – 1474DisorderedSequence analysisAdd BLAST34
Regioni1594 – 1652DisorderedSequence analysisAdd BLAST59
Regioni1741 – 1763DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi32 – 79PolyampholyteSequence analysisAdd BLAST48
Compositional biasi83 – 153PolarSequence analysisAdd BLAST71
Compositional biasi283 – 322PolarSequence analysisAdd BLAST40
Compositional biasi587 – 704PolarSequence analysisAdd BLAST118
Compositional biasi705 – 726PolyampholyteSequence analysisAdd BLAST22
Compositional biasi747 – 765PolarSequence analysisAdd BLAST19
Compositional biasi777 – 808PolarSequence analysisAdd BLAST32
Compositional biasi829 – 943PolarSequence analysisAdd BLAST115
Compositional biasi950 – 978PolarSequence analysisAdd BLAST29
Compositional biasi1010 – 1032PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1039 – 1085PolarSequence analysisAdd BLAST47
Compositional biasi1122 – 1147PolarSequence analysisAdd BLAST26
Compositional biasi1340 – 1382PolarSequence analysisAdd BLAST43
Compositional biasi1743 – 1757Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158180

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001298_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
I3N402

TreeFam database of animal gene trees

More...
TreeFami
TF329702

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12711, RRM_TNRC6A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019486, Argonaute_hook_dom
IPR026805, GW182_M_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
IPR034924, TNRC6A_RRM

The PANTHER Classification System

More...
PANTHERi
PTHR13020:SF28, PTHR13020:SF28, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10427, Ago_hook, 1 hit
PF12938, M_domain, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

I3N402-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLVAEPGLE ARCPGSQDTL LPEEWNRELE AKATKDVERN LSRDLVQEEE
60 70 80 90 100
QLMEEKKKKK DDKKKKEAAQ KKATEQKIKV PEQIKPSVSQ PQPANSNNGT
110 120 130 140 150
STATSTNNNA KRATANNQQQ QQQQQQPQQQ QQQPQQQQPP PSLQQQQQQQ
160 170 180 190 200
PPQPQALPRY PREVPPRFRH QEHKQLLKRG QHFPVIAANL GSAVKVLNSQ
210 220 230 240 250
SESSAVINQQ PQNNGEVQNS RTESDINHNT SGSHYENSQR GPVSSTSDSS
260 270 280 290 300
TNCKNAVVSD LLEKEVWPSA PGSDPELASE CVDADSASSS ESERNITIMA
310 320 330 340 350
SGSTGGEKDS LRNSTGLGSQ NKFVVGSSSN NVGHGSSTGP WGFSHGAIIS
360 370 380 390 400
TCQVSVDAPE SKSESSNNRM NAWGTVSSSS NGGLNPSTLN SASNHGAWPV
410 420 430 440 450
LENNGLALKG PVGSGNSGIN IQCSTIGQMP NNQSINSKVS GSSTHGTWGS
460 470 480 490 500
LQETCESEVS GTQKVSFSGQ PQNITTEMTG PNNTTNFMTS SLPNSGSVQN
510 520 530 540 550
NELPSSNTGA WRVSTMNHPQ IQAPSVMNGT SLSHLSNGES KSGGSYGTTW
560 570 580 590 600
GAYGSNYSGD KCSGPNGQAN GDTVNATLMQ PGINGPVGTN FQVNTNKGGS
610 620 630 640 650
VWESGAANSQ STSWGSGNGA NSGGSRRGWG TPAQNTGTNI PSVEWNKLPS
660 670 680 690 700
NQHSSDSANG NGKKFTNGWK STEEEDQGSA TSQTNEQSSV WAKTGGAVES
710 720 730 740 750
EGSTESTGRL EEKATGDSQS RDRRKLDQHT LLQSIVNRAD LDPRVLSNSG
760 770 780 790 800
WGQTPIKQNT AWDTETSPRG ERKTDNGTEA WGSSAAQTLN SGACMEKTGP
810 820 830 840 850
NGNDTSAVSG WGDPKPALRW GDSKGSNCQG GWEDDSAATG MIKSNQWGNC
860 870 880 890 900
KEEKSAWNDS QKSKQGWGDG QKASQGWSVS ATDNWGETSR SNHWGEANKK
910 920 930 940 950
SSSGGSDSDR SVSGWNELGK TSSFTWGNNI NPNNSSGWDE SAKPNPSQGW
960 970 980 990 1000
GDPPKSNQSL GWGDSSKPVS SPDWNKQQDL VGSWGIPPAA GKPPGTGWLG
1010 1020 1030 1040 1050
GPIPAPAKEE EPTGWEEPSP ESIRRKMEID DGTSAWGDPS KYNYKNVNMW
1060 1070 1080 1090 1100
NKNVPNGSSR SDQQAQVHQL LPSASAISSK EASSGSGWGE PWGEPSTPAT
1110 1120 1130 1140 1150
TVDNGTSAWG KPIDSGPSWG EPIAPASNTS TWGSSSVGPQ ALSKSGPKSM
1160 1170 1180 1190 1200
QDGWCGDDMP LPGNRPTGWE EEEDVEIGMW NSNSSQELNS SLNWPPYTKK
1210 1220 1230 1240 1250
MSSKGMMKGG NKQEEAWINP FVKQFSNISF SRDSPEENVQ SNKMDLSGGM
1260 1270 1280 1290 1300
LQDKRMEIDK HSLNIGDYNR TVGKGPGSRP QISKESSMER NPYFDKDGIV
1310 1320 1330 1340 1350
ADESQNMQFM SSQSMKLPPS NSALPNQALG SIAGLGMQNL NSVRQNGNPS
1360 1370 1380 1390 1400
MFGVGNTAAQ PRGLQQPPAQ PLSSSQPNLR AQVPPPLLSP QVPVSLLKYA
1410 1420 1430 1440 1450
PNNGGLNPLF GPQQVAMLNQ LSQLNQLSQI SQLQRLLAQQ QRAQSQRSVP
1460 1470 1480 1490 1500
SGNRQQQDQQ GRPLSVQQQM MQQSRQLDPN VLVKQPTPPS QQQSLHQPAM
1510 1520 1530 1540 1550
KSFLDNVMPH TTPELQKGPS PINAFSNFPI GLNSNLNVNM DMNSIKEPQS
1560 1570 1580 1590 1600
RLRKWTTVDS ISVNTSLDQN SSKHGAISSG FRLEESPFVP YDFMNSSSSP
1610 1620 1630 1640 1650
ASPPGSVGDG WPRAKSPNGS SSVNWPPEFR PGEPWKGYPN IDPETDPYVT
1660 1670 1680 1690 1700
PGSVINNLSI NTVREVDHLR DRNSGSSSSL NTTLPSTSAW SSIRASNYNV
1710 1720 1730 1740 1750
PLSSTAQSTS ARNSDSKLTW SPGSVTNTSL AHELWKVPLP PKNITAPSRP
1760 1770 1780 1790 1800
PPGLTGQKPP LSTWDNSPLR VGGGWGNSDA RYTPGSSWGE SSSGRITNWL
1810 1820 1830 1840 1850
VLKNLTPQID GSTLRTLCMQ HGPLITFHLN LPHGNALVRY SSKEEVVKAQ
1860 1870 1880 1890 1900
KSLHMCVLGN TTILAEFASE EEISRFFAQS QSLTPSPGWQ SLGSSQSRLG
1910 1920 1930 1940 1950
SLDCSHSFSS RTDLNHWNGA GLSGTNCGDL HGTSLWGTPH YSTSLWGPPS
1960 1970
SSDPRGISSP SPINAFLSVD HLGGGGESM
Length:1,979
Mass (Da):211,922
Last modified:November 22, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3BE4C0DB64C43FF5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3NBQ7I3NBQ7_ICTTR
Uncharacterized protein
TNRC6A
1,990Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AGTP01030980 Genomic DNA No translation available.
AGTP01030981 Genomic DNA No translation available.
AGTP01030982 Genomic DNA No translation available.
AGTP01030983 Genomic DNA No translation available.
AGTP01030984 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSTOT00000025917; ENSSTOP00000019098; ENSSTOG00000023394

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGTP01030980 Genomic DNA No translation available.
AGTP01030981 Genomic DNA No translation available.
AGTP01030982 Genomic DNA No translation available.
AGTP01030983 Genomic DNA No translation available.
AGTP01030984 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSSTOT00000025917; ENSSTOP00000019098; ENSSTOG00000023394

Phylogenomic databases

GeneTreeiENSGT00940000158180
HOGENOMiCLU_001298_2_0_1
InParanoidiI3N402
TreeFamiTF329702

Family and domain databases

CDDicd12711, RRM_TNRC6A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486, Argonaute_hook_dom
IPR026805, GW182_M_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
IPR034924, TNRC6A_RRM
PANTHERiPTHR13020:SF28, PTHR13020:SF28, 1 hit
PfamiView protein in Pfam
PF10427, Ago_hook, 1 hit
PF12938, M_domain, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3N402_ICTTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3N402
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: November 22, 2017
Last modified: August 12, 2020
This is version 47 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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