SMAD1

Functionⁱ

GO - Molecular functionⁱ

co-SMAD binding Source: Ensembl
DEAD/H-box RNA helicase binding Source: Ensembl
DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
identical protein binding Source: Ensembl
I-SMAD binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
primary miRNA binding Source: Ensembl
protein kinase binding Source: Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl

GO - Biological processⁱ

BMP signaling pathway Source: Ensembl
bone development Source: Ensembl
cardiac muscle cell proliferation Source: Ensembl
cartilage development Source: Ensembl
cellular response to organic cyclic compound Source: Ensembl
gamete generation Source: Ensembl
hindbrain development Source: Ensembl
homeostatic process Source: Ensembl
inflammatory response Source: Ensembl
MAPK cascade Source: Ensembl
mesodermal cell fate commitment Source: Ensembl
midbrain development Source: Ensembl
negative regulation of cell population proliferation Source: Ensembl
osteoblast fate commitment Source: Ensembl
positive regulation of cartilage development Source: Ensembl
positive regulation of osteoblast differentiation Source: Ensembl
positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
positive regulation of sprouting angiogenesis Source: Ensembl
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: Ensembl
SMAD protein complex assembly Source: Ensembl
SMAD protein signal transduction Source: Ensembl
transforming growth factor beta receptor signaling pathway Source: InterPro
ureteric bud development Source: Ensembl

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotation
Biological process	Transcription, Transcription regulationUniRule annotationARBA annotation
Ligand	Metal-bindingARBA annotation, ZincARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mothers against decapentaplegic homologUniRule annotation Short name: MAD homologUniRule annotation Short name: Mothers against DPP homologUniRule annotation Alternative name(s): SMAD family memberUniRule annotation
Gene namesⁱ	Name:SMAD1Imported
Organismⁱ	Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)Imported
Taxonomic identifierⁱ	43179 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciuromorpha › Sciuridae › Xerinae › Marmotini › Ictidomys
Proteomesⁱ	UP000005215 Componentⁱ: Unassembled WGS sequence

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation, NucleusUniRule annotationARBA annotation

Interactionⁱ

GO - Molecular functionⁱ

co-SMAD binding Source: Ensembl
DEAD/H-box RNA helicase binding Source: Ensembl
identical protein binding Source: Ensembl
I-SMAD binding Source: Ensembl
protein kinase binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	43179.ENSSTOP00000009717

STRINGⁱ

43179.ENSSTOP00000009717

Structureⁱ

3D structure databases

SMRⁱ	I3MG69
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	12 – 136	MH1InterPro annotationAdd BLAST		125
Domainⁱ	271 – 465	MH2InterPro annotationAdd BLAST		195

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	162 – 249	DisorderedSequence analysisAdd BLAST		88

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	34 – 54	Sequence analysisAdd BLAST		21

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	171 – 216	PolarSequence analysisAdd BLAST		46
Compositional biasⁱ	217 – 231	Pro-richSequence analysisAdd BLAST		15

Sequence similaritiesⁱ

Belongs to the dwarfin/SMAD family.UniRule annotationARBA annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3701, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154391
HOGENOMⁱ	CLU_026736_0_2_1
InParanoidⁱ	I3MG69
Database of Orthologous Groups More...OrthoDBⁱ	608001at2759
TreeFamⁱ	TF314923

Family and domain databases

Gene3Dⁱ	2.60.200.10, 1 hit 3.90.520.10, 1 hit
InterProⁱ	View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf
PANTHERⁱ	PTHR13703, PTHR13703, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit
SMARTⁱ	View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit
SUPFAMⁱ	SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit
PROSITEⁱ	View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

I3MG69-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE 
        60         70         80         90        100
LEKALSCPGQ PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH 
       110        120        130        140        150
HELKPLECCE FPFGSKQKEV CINPYHYKRV ESPVLPPVLV PRHSEYNPQH 
       160        170        180        190        200
SLLAQFRNLG QNEPHMPLNA TFPDSFQQPN SHPFPHSPNS SYPNSPGSSS 
       210        220        230        240        250
STYPHSPTSS DPGSPFQMPA DTPPPAYLPP EDPMTQDGSQ PMDTNMMAPS 
       260        270        280        290        300
LPSEINRGDV QAVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT 
       310        320        330        340        350
DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD 
       360        370        380        390        400
SSIFVQSRNC NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF 
       410        420        430        440        450
ETVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIEIHL HGPLQWLDKV 
       460 
LTQMGSPHNP ISSVS

Length:465

Mass (Da):52,250

Last modified:November 22, 2017 - v2

Checksum:ⁱ7C2E679F72B15C4F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AGTP01049153 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_005327605.1, XM_005327548.2

Genome annotation databases

Ensemblⁱ	ENSSTOT00000010834; ENSSTOP00000009717; ENSSTOG00000010836

Ensemblⁱ

ENSSTOT00000010834; ENSSTOP00000009717; ENSSTOG00000010836

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
I3MG69	Mothers against decapentaplegic homolog 1		BOVIN		465	UniRef100_Q1JQA2
Mothers against decapentaplegic homolog (Fragment)		wild yak		466
mothers against decapentaplegic homolog 1		Bison bison bison		465
mothers against decapentaplegic homolog 1		BOSIN		465
Mothers against decapentaplegic homolog		BOBOX		465
+4

Protein	Similar proteins		Species	Score	Length	Source
I3MG69	Mothers against decapentaplegic homolog 1	)	HUMAN		465	UniRef90_Q15797
Mothers against decapentaplegic homolog 1		RAT		468
Mothers against decapentaplegic homolog 1	)	MOUSE		465
Mothers against decapentaplegic homolog 1		BOVIN		465
Mothers against decapentaplegic homolog		MACNE		465
+257

Protein	Similar proteins		Species	Score	Length	Source
I3MG69	Mothers against decapentaplegic homolog 1	)	HUMAN		465	UniRef50_Q15797
Mothers against decapentaplegic homolog 1		RAT		468
Mothers against decapentaplegic homolog 1		BOVIN		465
Mothers against decapentaplegic homolog 1	)	MOUSE		465
Mothers against decapentaplegic homolog 1		DANRE		472
+991

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AGTP01049153 Genomic DNA No translation available.
RefSeqⁱ	XP_005327605.1, XM_005327548.2

3D structure databases

SMRⁱ	I3MG69
ModBaseⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	43179.ENSSTOP00000009717

STRINGⁱ

43179.ENSSTOP00000009717

Genome annotation databases

Ensemblⁱ	ENSSTOT00000010834; ENSSTOP00000009717; ENSSTOG00000010836

Ensemblⁱ

ENSSTOT00000010834; ENSSTOP00000009717; ENSSTOG00000010836

Phylogenomic databases

eggNOGⁱ	KOG3701, Eukaryota
GeneTreeⁱ	ENSGT00940000154391
HOGENOMⁱ	CLU_026736_0_2_1
InParanoidⁱ	I3MG69
OrthoDBⁱ	608001at2759
TreeFamⁱ	TF314923

Family and domain databases

Gene3Dⁱ	2.60.200.10, 1 hit 3.90.520.10, 1 hit
InterProⁱ	View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf
PANTHERⁱ	PTHR13703, PTHR13703, 1 hit
Pfamⁱ	View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit
SMARTⁱ	View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit
SUPFAMⁱ	SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit
PROSITEⁱ	View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	I3MG69_ICTTR
Accessionⁱ	I3MG69Primary (citable) accession number: I3MG69
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 11, 2012
	Last sequence update:	November 22, 2017
	Last modified:	October 7, 2020
	This is version 50 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - I3MG69 (I3MG69_ICTTR)

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Mothers against decapentaplegic homolog

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ