UniProtKB - I3MG69 (I3MG69_ICTTR)
Protein
Mothers against decapentaplegic homolog
Gene
SMAD1
Organism
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Status
Functioni
GO - Molecular functioni
- co-SMAD binding Source: Ensembl
- DEAD/H-box RNA helicase binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- identical protein binding Source: Ensembl
- I-SMAD binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- primary miRNA binding Source: Ensembl
- protein kinase binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- BMP signaling pathway Source: Ensembl
- bone development Source: Ensembl
- cardiac muscle cell proliferation Source: Ensembl
- cartilage development Source: Ensembl
- cellular response to organic cyclic compound Source: Ensembl
- gamete generation Source: Ensembl
- hindbrain development Source: Ensembl
- homeostatic process Source: Ensembl
- inflammatory response Source: Ensembl
- MAPK cascade Source: Ensembl
- mesodermal cell fate commitment Source: Ensembl
- midbrain development Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- osteoblast fate commitment Source: Ensembl
- positive regulation of cartilage development Source: Ensembl
- positive regulation of osteoblast differentiation Source: Ensembl
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
- positive regulation of sprouting angiogenesis Source: Ensembl
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: Ensembl
- SMAD protein complex assembly Source: Ensembl
- SMAD protein signal transduction Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: InterPro
- ureteric bud development Source: Ensembl
Keywordsi
Molecular function | DNA-bindingUniRule annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-bindingARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Mothers against decapentaplegic homologUniRule annotationShort name: MAD homologUniRule annotation Short name: Mothers against DPP homologUniRule annotation Alternative name(s): SMAD family memberUniRule annotation |
Gene namesi | Name:SMAD1Imported |
Organismi | Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)Imported |
Taxonomic identifieri | 43179 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciuromorpha › Sciuridae › Xerinae › Marmotini › Ictidomys |
Proteomesi |
|
Subcellular locationi
Nucleus
- nuclear inner membrane Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB-SubCell
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationARBA annotationInteractioni
GO - Molecular functioni
- co-SMAD binding Source: Ensembl
- DEAD/H-box RNA helicase binding Source: Ensembl
- identical protein binding Source: Ensembl
- I-SMAD binding Source: Ensembl
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 43179.ENSSTOP00000009717 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 136 | MH1InterPro annotationAdd BLAST | 125 | |
Domaini | 271 – 465 | MH2InterPro annotationAdd BLAST | 195 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 162 – 249 | DisorderedSequence analysisAdd BLAST | 88 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 34 – 54 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 171 – 216 | PolarSequence analysisAdd BLAST | 46 | |
Compositional biasi | 217 – 231 | Pro-richSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG3701, Eukaryota |
GeneTreei | ENSGT00940000154391 |
HOGENOMi | CLU_026736_0_2_1 |
InParanoidi | I3MG69 |
OrthoDBi | 608001at2759 |
TreeFami | TF314923 |
Family and domain databases
Gene3Di | 2.60.200.10, 1 hit 3.90.520.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 1 hit |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
i Sequence
Sequence statusi: Complete.
I3MG69-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE
60 70 80 90 100
LEKALSCPGQ PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH
110 120 130 140 150
HELKPLECCE FPFGSKQKEV CINPYHYKRV ESPVLPPVLV PRHSEYNPQH
160 170 180 190 200
SLLAQFRNLG QNEPHMPLNA TFPDSFQQPN SHPFPHSPNS SYPNSPGSSS
210 220 230 240 250
STYPHSPTSS DPGSPFQMPA DTPPPAYLPP EDPMTQDGSQ PMDTNMMAPS
260 270 280 290 300
LPSEINRGDV QAVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT
310 320 330 340 350
DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD
360 370 380 390 400
SSIFVQSRNC NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF
410 420 430 440 450
ETVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIEIHL HGPLQWLDKV
460
LTQMGSPHNP ISSVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AGTP01049153 Genomic DNA No translation available. |
RefSeqi | XP_005327605.1, XM_005327548.2 |
Genome annotation databases
Ensembli | ENSSTOT00000010834; ENSSTOP00000009717; ENSSTOG00000010836 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AGTP01049153 Genomic DNA No translation available. |
RefSeqi | XP_005327605.1, XM_005327548.2 |
3D structure databases
SMRi | I3MG69 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 43179.ENSSTOP00000009717 |
Genome annotation databases
Ensembli | ENSSTOT00000010834; ENSSTOP00000009717; ENSSTOG00000010836 |
Phylogenomic databases
eggNOGi | KOG3701, Eukaryota |
GeneTreei | ENSGT00940000154391 |
HOGENOMi | CLU_026736_0_2_1 |
InParanoidi | I3MG69 |
OrthoDBi | 608001at2759 |
TreeFami | TF314923 |
Family and domain databases
Gene3Di | 2.60.200.10, 1 hit 3.90.520.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 1 hit |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I3MG69_ICTTR | |
Accessioni | I3MG69Primary (citable) accession number: I3MG69 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | November 22, 2017 | |
Last modified: | October 7, 2020 | |
This is version 50 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |