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Protein

Gap junction protein

Gene

GJA4

Organism
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.UniRule annotationSAAS annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction proteinUniRule annotation
Gene namesi
Name:GJA4Imported
OrganismiIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)Imported
Taxonomic identifieri43179 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciuromorphaSciuridaeXerinaeMarmotiniIctidomys
Proteomesi
  • UP000005215 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei78 – 99HelicalSequence analysisAdd BLAST22
Transmembranei208 – 233HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Gap junctionUniRule annotationSAAS annotation, Membrane

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi43179.ENSSTOP00000006816

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 76CNXInterPro annotationAdd BLAST34
Domaini165 – 231Connexin_CCCInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the connexin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IF97 Eukaryota
ENOG4110JTW LUCA
GeneTreeiENSGT00910000143998
InParanoidiI3MA35
OMAiSDFECNT
OrthoDBiEOG091G0FKH
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002263 Connexin37
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01134 CONNEXINA4
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

I3MA35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS
60 70 80 90 100
DFQCNTAQPG CTNVCYDLAF PISHVRYWVL QFLFVSTPTL VYLGHVIYLS
110 120 130 140 150
RREERLRQKE GELRALPVKD PHVERALAAV ERQMAKISVA EDGRLRIRGA
160 170 180 190 200
LMGTYVASVL CKSMLEAGFL YGQWRLYGWT MEPVFVCQRA PCPHFVDCYV
210 220 230 240 250
SRPTEKTIFI IFMLVVGVIS LVLNLLELAY LLCRCLSRGI RAQQGRDTTP
260 270 280 290 300
AQGTSSDPYP EQVFFYLPMG EGPSSPPCPT YNGLSSTEQN WANLTTEERL
310 320 330
ASSNPPPLFL DPPPQTGRKS PSRPSTCSSK KQYV
Length:334
Mass (Da):37,610
Last modified:July 11, 2012 - v1
Checksum:iE0A0E90BF277D465
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGTP01008206 Genomic DNA No translation available.
RefSeqiXP_005317844.1, XM_005317787.1

Genome annotation databases

EnsembliENSSTOT00000007624; ENSSTOP00000006816; ENSSTOG00000007636
GeneIDi101969534

Similar proteinsi

Entry informationi

Entry nameiI3MA35_ICTTR
AccessioniPrimary (citable) accession number: I3MA35
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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