UniProtKB - I3M2P5 (I3M2P5_ICTTR)
Protein
BHLH domain-containing protein
Gene
MLX
Organism
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl
- transcription factor binding Source: Ensembl
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: BHLH domain-containing proteinInterPro annotation |
Gene namesi | Name:MLXImported |
Organismi | Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)Imported |
Taxonomic identifieri | 43179 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciuromorpha › Sciuridae › Xerinae › Marmotini › Ictidomys |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nuclear membrane Source: Ensembl
- nucleoplasm Source: Ensembl
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- transcription factor binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 43179.ENSSTOP00000003276 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 125 – 183 | BHLHInterPro annotationAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 91 – 141 | DisorderedSequence analysisAdd BLAST | 51 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 180 – 207 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 91 – 106 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 107 – 141 | PolyampholyteSequence analysisAdd BLAST | 35 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG1319, Eukaryota |
GeneTreei | ENSGT00940000157377 |
HOGENOMi | CLU_083204_0_0_1 |
InParanoidi | I3M2P5 |
TreeFami | TF318841 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032647, Mlx |
PANTHERi | PTHR15741:SF25, PTHR15741:SF25, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
I3M2P5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEPGASPED PWVKASPVGA CGRAGWACAH RGLRRLGASF LSPESPLFSD
60 70 80 90 100
PGLQIDSFYP AAAKVEYAYS DNSLDPGLFV ENTRKGSVVS RANSIGSTSA
110 120 130 140 150
SSVPNTDDED SDYHQESYKE SYKDRRRRAH TQSEQKRRDA IKRGYDDLQT
160 170 180 190 200
IVPTCQQQDF SIGSQKLSKA IVLQKTIDYI QFLHKEKKKQ EEEVSTLRKD
210 220 230 240 250
VTALKIMKVN YEQIVKAHQD NPHEGEDQVS DQDKFNVFQG VMDSLFESFN
260 270 280 290
ASISVASFQE LSACVFSWIE EHCKPQTLRE IVIGVLHQLK NQLY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A287D6D4 | A0A287D6D4_ICTTR | BHLH domain-containing protein | MLX | 244 | Annotation score: | ||
A0A287DGJ4 | A0A287DGJ4_ICTTR | BHLH domain-containing protein | MLX | 214 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AGTP01023508 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSSTOT00000003660; ENSSTOP00000003276; ENSSTOG00000003660 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AGTP01023508 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 43179.ENSSTOP00000003276 |
Genome annotation databases
Ensembli | ENSSTOT00000003660; ENSSTOP00000003276; ENSSTOG00000003660 |
Phylogenomic databases
eggNOGi | KOG1319, Eukaryota |
GeneTreei | ENSGT00940000157377 |
HOGENOMi | CLU_083204_0_0_1 |
InParanoidi | I3M2P5 |
TreeFami | TF318841 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032647, Mlx |
PANTHERi | PTHR15741:SF25, PTHR15741:SF25, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I3M2P5_ICTTR | |
Accessioni | I3M2P5Primary (citable) accession number: I3M2P5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | November 22, 2017 | |
Last modified: | August 12, 2020 | |
This is version 46 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |