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Entry version 41 (05 Jun 2019)
Sequence version 2 (22 Nov 2017)
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Protein
Submitted name:

Calcium-binding and coiled-coil domain-containing protein 1 isoform 1

Gene

CALCOCO1

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calcium-binding and coiled-coil domain-containing protein 1 isoform 1Imported
Submitted name:
Calcium-binding and coiled-coil domain-containing protein 1 isoform X2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CALCOCO1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000028481 Expressed in 6 organ(s), highest expression level in lung

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000027143

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 118SKICHInterPro annotationAdd BLAST104
Domaini122 – 596CALCOCO1InterPro annotationAdd BLAST475
Domaini654 – 680Zn-C2H2_12InterPro annotationAdd BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni511 – 605DisorderedSequence analysisAdd BLAST95

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili146 – 208Sequence analysisAdd BLAST63
Coiled coili251 – 334Sequence analysisAdd BLAST84
Coiled coili419 – 460Sequence analysisAdd BLAST42

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHKH Eukaryota
ENOG410ZVZ6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183025

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
I3LSQ0

Identification of Orthologs from Complete Genome Data

More...
OMAi
WQEEQSA

Database of Orthologous Groups

More...
OrthoDBi
179838at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329501

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012852 CALCOCO1-like
IPR041641 CALCOCO1/2_Zn-C2H2
IPR041611 SKICH

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07888 CALCOCO1, 1 hit
PF17751 SKICH, 1 hit
PF18112 Zn-C2H2_12, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

I3LSQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEESSLSRAP SRGGVSFLNV ARTYIPNTKV ECHYTLPPGT VPSASDWIGI
60 70 80 90 100
FKVEAACVRD YHTFVWSSVP EGVTDGSPIH TSVQFQASYL PKPGAQLYQF
110 120 130 140 150
RYVNRQGRVC GQSPPFQFRE PRPMDELVTL EETDGGSDIL LVVPKATVLQ
160 170 180 190 200
NQLDESQQER NDLMQLKLQL EGQVTELRSR VQELETALAT ARQEHAELSE
210 220 230 240 250
QYKGLARSHG ELTEERDILS RQQGDHVARI LELEEDIQTI SEKVLTKEVE
260 270 280 290 300
LDRVRDAVKA LTREQEKLLG QLKEVQADKE QSEAELQMAQ QENRRLNLEL
310 320 330 340 350
QEAKGRQEEQ SAQAQRLKDK VAQMKDTLGQ AQQRVAELEP LKEQLRGAQE
360 370 380 390 400
LAASSQQKAT LLGEELASTA GARDRTIAEL HRSRLEVAGV NGRLAELSLH
410 420 430 440 450
LKEEKSQWSK ERAGLLQSVE AEKDKILKLS AEILRLEKAV QEEKTQNQAF
460 470 480 490 500
KTELAREKDS SLVQLSESKR ELTELRSALR VLQKEKEQLQ EEKQELLEYM
510 520 530 540 550
RKLEARLEKV ADEKWSEDPA TEDEEAAAGL SCPVALSDSE DESPEDMRLP
560 570 580 590 600
PYGLCERGDP DSSPAGPREA SPLVVISQPA PIAPHLSGPA EDSSSDSEAE
610 620 630 640 650
DEKSVLMAAV QSGGEEANLL LPELGSAFYD MASGFAVGPL SEAGPGGPAT
660 670 680 690
PPWKECPICK ERFPAESEKD GLEHHMDGHF FFSTQDPFTF E
Length:691
Mass (Da):76,961
Last modified:November 22, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63219DFFF6AC7335
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A287A5M8A0A287A5M8_PIG
Calcium-binding and coiled-coil dom...
CALCOCO1
715Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEMK02000028 Genomic DNA No translation available.
DQIR01065245 Transcribed RNA Translation: HDA20721.1
DQIR01076346 Transcribed RNA Translation: HDA31822.1
DQIR01134045 Transcribed RNA Translation: HDA89521.1
DQIR01154449 Transcribed RNA Translation: HDB09926.1

NCBI Reference Sequences

More...
RefSeqi
XP_005652631.1, XM_005652574.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000032347; ENSSSCP00000027143; ENSSSCG00000028481
ENSSSCT00000037970; ENSSSCP00000049296; ENSSSCG00000028481

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100625970

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:100625970

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000028 Genomic DNA No translation available.
DQIR01065245 Transcribed RNA Translation: HDA20721.1
DQIR01076346 Transcribed RNA Translation: HDA31822.1
DQIR01134045 Transcribed RNA Translation: HDA89521.1
DQIR01154449 Transcribed RNA Translation: HDB09926.1
RefSeqiXP_005652631.1, XM_005652574.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000027143

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000032347; ENSSSCP00000027143; ENSSSCG00000028481
ENSSSCT00000037970; ENSSSCP00000049296; ENSSSCG00000028481
GeneIDi100625970
KEGGissc:100625970

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57658

Phylogenomic databases

eggNOGiENOG410IHKH Eukaryota
ENOG410ZVZ6 LUCA
GeneTreeiENSGT00950000183025
InParanoidiI3LSQ0
OMAiWQEEQSA
OrthoDBi179838at2759
TreeFamiTF329501

Gene expression databases

BgeeiENSSSCG00000028481 Expressed in 6 organ(s), highest expression level in lung

Family and domain databases

InterProiView protein in InterPro
IPR012852 CALCOCO1-like
IPR041641 CALCOCO1/2_Zn-C2H2
IPR041611 SKICH
PfamiView protein in Pfam
PF07888 CALCOCO1, 1 hit
PF17751 SKICH, 1 hit
PF18112 Zn-C2H2_12, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3LSQ0_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3LSQ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: November 22, 2017
Last modified: June 5, 2019
This is version 41 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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