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Entry version 51 (03 Jul 2019)
Sequence version 1 (11 Jul 2012)
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Protein
Submitted name:

Nuclear receptor-interacting protein 1 isoform X1

Gene

NRIP1

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-3899300 SUMOylation of transcription cofactors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclear receptor-interacting protein 1 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRIP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000021038 Expressed in 5 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
I3LP18 SS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000025843

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 330NRIP1_repr_1InterPro annotationAdd BLAST304
Domaini409 – 734NRIP1_repr_2InterPro annotationAdd BLAST326
Domaini846 – 1156NRIP1_repr_4InterPro annotationAdd BLAST311

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni32 – 58DisorderedSequence analysisAdd BLAST27
Regioni388 – 434DisorderedSequence analysisAdd BLAST47
Regioni468 – 493DisorderedSequence analysisAdd BLAST26
Regioni636 – 699DisorderedSequence analysisAdd BLAST64
Regioni721 – 740DisorderedSequence analysisAdd BLAST20
Regioni761 – 784DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi402 – 434PolarSequence analysisAdd BLAST33
Compositional biasi473 – 488PolyampholyteSequence analysisAdd BLAST16
Compositional biasi636 – 658PolarSequence analysisAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFW7 Eukaryota
ENOG410XPVS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007999

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
I3LP18

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDDLHIH

TreeFam database of animal gene trees

More...
TreeFami
TF332210

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026649 NRIP1
IPR031405 NRIP1_RD1
IPR031406 NRIP1_RD2
IPR031407 NRIP1_RD3
IPR031408 NRIP1_RD4

The PANTHER Classification System

More...
PANTHERi
PTHR15088 PTHR15088, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15687 NRIP1_repr_1, 1 hit
PF15688 NRIP1_repr_2, 1 hit
PF15689 NRIP1_repr_3, 1 hit
PF15690 NRIP1_repr_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

I3LP18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHGEELGSD VHQDSIVLTY LEGLLMHQAA EGSGTAVDKK SAGRNEEDQN
60 70 80 90 100
FNISGNAFPT CQSNGPVLNT HTYQGSGMLH LKKARLLQSS EDWNAAKRKR
110 120 130 140 150
LSDSIVNLNV KKEALLAGMV DNVPKGKQDS TLLASLLQSF SSRLQTVALS
160 170 180 190 200
QQIRQSLKEQ GYALSHDSLK VEKDLRCYGV ASSHLKTLLK KSKAKDQKPD
210 220 230 240 250
TNLPDVTKNL IRERFVESPH HVGQSGTKVL SEPLSCAARL QAVASMVEKR
260 270 280 290 300
ASPATSPKPS VACSQLALLL SSEAHLQQYS REHALKTQNA NQAASERLAA
310 320 330 340 350
MARLQENGQK DVGSFQVSKG VSGHLNGQAR TSSNKLMASK STTFQSPMGL
360 370 380 390 400
VPSSPKNAGY KNSLERNNIK QAANNSLLLH LLKSQTIPKP MNGHSHSERG
410 420 430 440 450
SIFEESSTPT TIDDYSDNNP SFTDDSSGDE SSYSNCVPID LSCKHRTEKP
460 470 480 490 500
EPDQPVSLDN LTQSLLNTWD PKVPEVDNKE DQDTSKNSRL NSHQKVTLLQ
510 520 530 540 550
LLLGHKNEEN VERNNSPQEV HSDVTKFSTQ NYARTSVIES PGTNRTTPVS
560 570 580 590 600
TPPLLASAKA ESPINLSQHS LVIRWNSPPY ACGPPSEKPT NATSNRLMDL
610 620 630 640 650
TKSKDLQGEK PVQNEGAQNS ATFSASKLLK NLAQCGMQSS MSGEEQRPSK
660 670 680 690 700
QLLSVNTDKP TGVMERLGSP LLANKTNPAE ENKAFGSHSA GPEPGLSGSE
710 720 730 740 750
IENLLERRTV LQLLLGNSNK GKMEKKEKIP LREGSTQEHT DRALSEQILM
760 770 780 790 800
VKIKSEPCDD FHAHTPDVHS SPDAQGAPFL GMAPPVQRGA AALPAPEDLK
810 820 830 840 850
SEPASPQDFS FSKNGLLSRL LRQNQESYPA DDLDGSHRNS ELTLLESKNL
860 870 880 890 900
CMVPKKRKLY TEPLENPFKK MKNNIVDAAG SHSAPEVLYG SLLNQQELKL
910 920 930 940 950
SRNELDLKYP GSHSSPSESE HRSWARESKS FNVLKQLLLS ENCVRDLSQH
960 970 980 990 1000
RSNSVGDSKK KGCKNSVTNS KPEFSISSLN GLMYSAAQPS SCMDSRTFPY
1010 1020 1030 1040 1050
PGGVKTPLSP PFPEHLGCTG SRPESGLVNG CSMPSEKRPI KWVITDAEKN
1060 1070 1080 1090 1100
EYEKDSPRLT KTNPILYYML QKGGNSVTSR ETQDKDVWRE PSSAENISQV
1110 1120 1130 1140 1150
TIKEELLPAA ETKASFFNLR SPYNSHMGNN ASRPHSANGE VYGLLGNMLT

IKKESE
Length:1,156
Mass (Da):126,476
Last modified:July 11, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3449B378B6F92D74
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEMK02000091 Genomic DNA No translation available.
DQIR01100579 Transcribed RNA Translation: HDA56055.1

NCBI Reference Sequences

More...
RefSeqi
XP_013837987.1, XM_013982533.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000028007; ENSSSCP00000025843; ENSSSCG00000021038
ENSSSCT00000037452; ENSSSCP00000041979; ENSSSCG00000021038

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000091 Genomic DNA No translation available.
DQIR01100579 Transcribed RNA Translation: HDA56055.1
RefSeqiXP_013837987.1, XM_013982533.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025843

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000028007; ENSSSCP00000025843; ENSSSCG00000021038
ENSSSCT00000037452; ENSSSCP00000041979; ENSSSCG00000021038

Phylogenomic databases

eggNOGiENOG410IFW7 Eukaryota
ENOG410XPVS LUCA
GeneTreeiENSGT00390000007999
InParanoidiI3LP18
OMAiCDDLHIH
TreeFamiTF332210

Enzyme and pathway databases

ReactomeiR-SSC-3899300 SUMOylation of transcription cofactors

Gene expression databases

BgeeiENSSSCG00000021038 Expressed in 5 organ(s), highest expression level in liver
GenevisibleiI3LP18 SS

Family and domain databases

InterProiView protein in InterPro
IPR026649 NRIP1
IPR031405 NRIP1_RD1
IPR031406 NRIP1_RD2
IPR031407 NRIP1_RD3
IPR031408 NRIP1_RD4
PANTHERiPTHR15088 PTHR15088, 1 hit
PfamiView protein in Pfam
PF15687 NRIP1_repr_1, 1 hit
PF15688 NRIP1_repr_2, 1 hit
PF15689 NRIP1_repr_3, 1 hit
PF15690 NRIP1_repr_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3LP18_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3LP18
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: July 3, 2019
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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