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Protein
Submitted name:

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Gene

PIK3C2A

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotation, Transferase

Enzyme and pathway databases

ReactomeiR-SSC-1660499 Synthesis of PIPs at the plasma membrane
R-SSC-1660514 Synthesis of PIPs at the Golgi membrane
R-SSC-1660516 Synthesis of PIPs at the early endosome membrane
R-SSC-1660517 Synthesis of PIPs at the late endosome membrane
R-SSC-432722 Golgi Associated Vesicle Biogenesis
R-SSC-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alphaImported
Gene namesi
Name:PIK3C2AImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiI3LLX2
PeptideAtlasiI3LLX2
PRIDEiI3LLX2

Expressioni

Gene expression databases

BgeeiENSSSCG00000025406 Expressed in 5 organ(s), highest expression level in lung

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025092

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini423 – 511PI3K-RBDInterPro annotationAdd BLAST89
Domaini685 – 842C2 PI3K-typeInterPro annotationAdd BLAST158
Domaini862 – 1038PIK helicalInterPro annotationAdd BLAST177
Domaini1134 – 1398PI3K/PI4KInterPro annotationAdd BLAST265
Domaini1423 – 1539PXInterPro annotationAdd BLAST117
Domaini1551 – 1663C2InterPro annotationAdd BLAST113

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0905 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00760000119110
InParanoidiI3LLX2
OrthoDBiEOG091G00FC
TreeFamiTF102031

Family and domain databases

CDDicd05176 PI3Kc_C2_alpha, 1 hit
Gene3Di1.10.1070.11, 1 hit
2.60.40.150, 2 hits
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR001683 Phox
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR037705 PI3K-C2-alpha_dom
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR036871 PX_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00142 PI3K_C2, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SM00312 PX, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

I3LLX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQISSNNGF KQCSSSHLEP TRTKDVDKEE ALQMEAEALA KLQKDRRVTD
60 70 80 90 100
NQRGFELSSS MREKAQVYNK QDYDLMMFPE SDTQKRALDI DVEKLTQAEL
110 120 130 140 150
EKLLLDDDFE TKKTPVLPVT PFLSPSFSAQ LCRRPIQRGQ WPPGLSGPSS
160 170 180 190 200
YTLPSIYQST CSSKQTAFQN GFNPRMPTFP STEPIYLSLP GQSPYFSYPL
210 220 230 240 250
TPATPFYPQG SLPIYRPVVS PDMAKLFDKI ASTSEFLKNG KARTDLEITN
260 270 280 290 300
SKATSSNLQV SPKSKDISKF DWLDLDPLSK PKVDNVEVLD HEEEKNIPRL
310 320 330 340 350
LADDPWDAVL LEERSPASCH LERKVNGKSL SGATVTRSQS LNIRTTQLTK
360 370 380 390 400
VQGQISQKDP NGTITLPTES SLLQEIEVQN EEVAAFCQSI TKLKTNFPYT
410 420 430 440 450
NHCTNPGYLL SPVTAQRNIC GENASVKVSI EIEGFQLPVT FTCDVSSTVE
460 470 480 490 500
IIIMQALCWV HDDLNQVDVG SYVLKVCGQE EVLQNNHCLG SHEHIQNCRK
510 520 530 540 550
WDTEIKLQLL TLSAMCQNLA RTAEDDEMPV DLNKHLHQIE KPYKEVMTRH
560 570 580 590 600
PVEELLDSYH SQVELALQIE NQHRAVDQVI KAVRKICSAL DGVETLAITE
610 620 630 640 650
SVKKLKRAVN LPRSKSAEVT SLSGGGGDAS KSSTRGALNP ENPVQVSMDQ
660 670 680 690 700
LTAAVYDLLR LHANSSRGSV DCAQSNRNMK EAWTATEQLQ FTIFAAHGIS
710 720 730 740 750
SNWVSNYEKY YLICSLTYNG KDLFKPIQSK KVGTYKNFFY LIKWDELIIF
760 770 780 790 800
PIQISQLPLE SLLHLTLFGI LNQSNGSSPD SNKQRKGPEA LGKVSLPFDF
810 820 830 840 850
KRFLTCGTKL LYLWTSSHTN PIPGTPPKGY VMERIVLQVD FPSPTFDIIY
860 870 880 890 900
TTPQVDGSSI QQHNLETLEN DIKDKLLDVL HKDSSLGLSK EDKAFLWEKR
910 920 930 940 950
YYCLKHPNCL PKVLTSAPNW KWVNLAKTYS LLRQWPPLHP LTALELLDSK
960 970 980 990 1000
FADQEVRSLA VTWIEAISDD ELIDLLPQFV QALKYEIYLN SSLVRFLLSR
1010 1020 1030 1040 1050
AMGNIQIAHN LYWLLKDALH DAQFGTRYEH ILGALLSVGG KGLREELLKQ
1060 1070 1080 1090 1100
TKLVQLLGGV AEKVRQATGS ARQVVLQRSM ERVQSFFLRN KCRLPLNPSL
1110 1120 1130 1140 1150
VAKELNIKSC SFFSSNAVPL KVTMVNADPV GEEINVMFKV GEDLRQDMLA
1160 1170 1180 1190 1200
LQMIKIMDKI WLKEGLDLRM VIFKCLSTGR DRGMVELVPA SDTLRKIQVE
1210 1220 1230 1240 1250
YGVTGSFKDK PLAEWLRKYN PSEEEYEKAS ENFIYSCAGC CVATYVLGIC
1260 1270 1280 1290 1300
DRHNDNIMLR STGHMFHIDF GKFLGHAQMF GSFKRDRAPF VLTSDMAYVI
1310 1320 1330 1340 1350
NGGEKPTIRF QLFVDLCCQA YNLIRKQTNL FLNLLSLMIP SGLPELTSTQ
1360 1370 1380 1390 1400
DLKYVRDALQ PQTTDAEATI FFTRLIESSL GSIATKFNFF IHNLAQLRFS
1410 1420 1430 1440 1450
GLPSNDEPIL SFSPKTYSFR QDGRIKEVSV FTYHKKYNPD KHYIYVVRIL
1460 1470 1480 1490 1500
REGQLEPSFV FRTFDEFQEL HNKLSIIFPL WKLPGFPNRM VLGRTHIKDV
1510 1520 1530 1540 1550
AAKRKIELNS YLQSLMSAST DVAECDLVCT FFHPLLRDEK AEGIARSADA
1560 1570 1580 1590 1600
GPFSPTPGQI GGAVKLSISY RNGTLFIMVM HIKDLVTEDG ADPNPYVKTY
1610 1620 1630 1640 1650
LLPDTHKTSK RKTKISRKTR NPTFNEMLVY SGYSKETLRQ RELQLSVLSA
1660 1670 1680
ESLRENFFLG GLTLPLKDFN LSKETVKWYQ LTAATYL
Length:1,687
Mass (Da):190,695
Last modified:November 22, 2017 - v2
Checksum:i6FEC95D5134276E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000009 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSSSCT00000024535; ENSSSCP00000025092; ENSSSCG00000025406

Similar proteinsi

Entry informationi

Entry nameiI3LLX2_PIG
AccessioniPrimary (citable) accession number: I3LLX2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: November 22, 2017
Last modified: September 12, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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