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Entry version 62 (02 Jun 2021)
Sequence version 2 (22 Nov 2017)
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Protein

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Gene

QPRT

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the catabolism of quinolinic acid (QA).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate.By similarity This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei102QuinolinateBy similarity1
Binding sitei171QuinolinateCombined sources1 Publication1
Binding sitei201QuinolinateCombined sources1 Publication1
Binding sitei222QuinolinateCombined sources1 Publication1
Binding sitei270Quinolinate; via amide nitrogenCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPyridine nucleotide biosynthesis
LigandNucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.2.19, 6170

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-196807, Nicotinate metabolism

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00253;UER00331

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nicotinate-nucleotide pyrophosphorylase [carboxylating]Curated (EC:2.4.2.191 Publication)
Alternative name(s):
Quinolinate phosphoribosyltransferase [decarboxylating]1 Publication
Short name:
QAPRTase1 Publication
Short name:
QPRTaseCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:QPRTImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced
  • UP000008227 Componenti: Chromosome 3

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:104041, QPRT

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004495431 – 299Nicotinate-nucleotide pyrophosphorylase [carboxylating]Add BLAST299

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
I3LK75

PeptideAtlas

More...
PeptideAtlasi
I3LK75

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000027454, Expressed in kidney and 22 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Hexamer formed by 3 homodimers.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000024489

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
I3LK75

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni8 – 12Important for hexamer formationBy similarity5
Regioni138 – 139Quinolinate bindingCombined sources1 Publication2
Regioni160 – 161Quinolinate bindingCombined sources1 Publication2
Regioni248 – 250Quinolinate bindingCombined sources1 Publication3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NadC/ModD family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3008, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002761

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
I3LK75

Identification of Orthologs from Complete Genome Data

More...
OMAi
DMIMLKD

Database of Orthologous Groups

More...
OrthoDBi
1263431at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300845

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01572, QPRTase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit
3.90.1170.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785, Aldolase_TIM
IPR004393, NadC
IPR027277, NadC/ModD
IPR036068, Nicotinate_pribotase-like_C
IPR037128, Quinolinate_PRibosylTase_N_sf
IPR002638, Quinolinate_PRibosylTrfase_C
IPR022412, Quinolinate_PRibosylTrfase_N

The PANTHER Classification System

More...
PANTHERi
PTHR32179, PTHR32179, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01729, QRPTase_C, 1 hit
PF02749, QRPTase_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006250, NadC_ModD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51690, SSF51690, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00078, nadC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

I3LK75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPEGLALLL PPATLATLAD SWLREDCPGL NPVALVTGAA PSQAVLWAKS
60 70 80 90 100
PGVLAGRPFF DAIFAQVNCQ VSWFLPEGSK LVPVAKVAEV QGPAHCLLLG
110 120 130 140 150
ERVALNMLAR CSGVASAAAT AVETARGTGW AGHVAGTRKT TPGFRLVEKY
160 170 180 190 200
GLLVGGATSH RYDLGGLVMV KDNHVVAAGG VEQAVQGARR AANFALKVEV
210 220 230 240 250
ECSSLQEALE AAEAGADLVL LDNFRPEELH PTAAALKAQF PTVGVEASGG
260 270 280 290
VTLDNLPQFC GPHIDVISLG MLTQAAPALD FSLKLFAEGT TPVPYARKS
Length:299
Mass (Da):30,994
Last modified:November 22, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EB249F870BA1C0B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5G2QMY5A0A5G2QMY5_PIG
Nicotinate-nucleotide pyrophosphory...
QPRT
278Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53V → I in AGF33488 (PubMed:23626766).Curated1
Sequence conflicti91Q → R in AGF33488 (PubMed:23626766).Curated1
Sequence conflicti182E → K in AGF33488 (PubMed:23626766).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEMK02000016 Genomic DNA No translation available.
KC185402 mRNA Translation: AGF33488.1

NCBI Reference Sequences

More...
RefSeqi
XP_003354604.1, XM_003354556.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000028901; ENSSSCP00000024489; ENSSSCG00000027454
ENSSSCT00035083639; ENSSSCP00035034776; ENSSSCG00035062217
ENSSSCT00045036063; ENSSSCP00045025077; ENSSSCG00045021123
ENSSSCT00065029104; ENSSSCP00065011890; ENSSSCG00065021888

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100623339

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:100623339

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000016 Genomic DNA No translation available.
KC185402 mRNA Translation: AGF33488.1
RefSeqiXP_003354604.1, XM_003354556.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I9AX-ray2.10A/B1-288[»]
SMRiI3LK75
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024489

Proteomic databases

PaxDbiI3LK75
PeptideAtlasiI3LK75

Genome annotation databases

EnsembliENSSSCT00000028901; ENSSSCP00000024489; ENSSSCG00000027454
ENSSSCT00035083639; ENSSSCP00035034776; ENSSSCG00035062217
ENSSSCT00045036063; ENSSSCP00045025077; ENSSSCG00045021123
ENSSSCT00065029104; ENSSSCP00065011890; ENSSSCG00065021888
GeneIDi100623339
KEGGissc:100623339

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23475
VGNCiVGNC:104041, QPRT

Phylogenomic databases

eggNOGiKOG3008, Eukaryota
GeneTreeiENSGT00390000002761
InParanoidiI3LK75
OMAiDMIMLKD
OrthoDBi1263431at2759
TreeFamiTF300845

Enzyme and pathway databases

UniPathwayiUPA00253;UER00331
BRENDAi2.4.2.19, 6170
ReactomeiR-SSC-196807, Nicotinate metabolism

Gene expression databases

BgeeiENSSSCG00000027454, Expressed in kidney and 22 other tissues

Family and domain databases

CDDicd01572, QPRTase, 1 hit
Gene3Di3.20.20.70, 1 hit
3.90.1170.20, 1 hit
InterProiView protein in InterPro
IPR013785, Aldolase_TIM
IPR004393, NadC
IPR027277, NadC/ModD
IPR036068, Nicotinate_pribotase-like_C
IPR037128, Quinolinate_PRibosylTase_N_sf
IPR002638, Quinolinate_PRibosylTrfase_C
IPR022412, Quinolinate_PRibosylTrfase_N
PANTHERiPTHR32179, PTHR32179, 1 hit
PfamiView protein in Pfam
PF01729, QRPTase_C, 1 hit
PF02749, QRPTase_N, 1 hit
PIRSFiPIRSF006250, NadC_ModD, 1 hit
SUPFAMiSSF51690, SSF51690, 1 hit
TIGRFAMsiTIGR00078, nadC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNADC_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3LK75
Secondary accession number(s): M1KCW7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 22, 2020
Last sequence update: November 22, 2017
Last modified: June 2, 2021
This is version 62 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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