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Entry version 62 (29 Sep 2021)
Sequence version 3 (11 Dec 2019)
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Protein

DNA-directed RNA polymerase subunit

Gene

POLR2A

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation, NucleotidyltransferaseUniRule annotationARBA annotation, Transferase
Biological processTranscription
LigandMagnesiumARBA annotation, Metal-bindingARBA annotation, ZincARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-112382, Formation of RNA Pol II elongation complex
R-SSC-113418, Formation of the Early Elongation Complex
R-SSC-5578749, Transcriptional regulation by small RNAs
R-SSC-674695, RNA Polymerase II Pre-transcription Events
R-SSC-6781823, Formation of TC-NER Pre-Incision Complex
R-SSC-6782135, Dual incision in TC-NER
R-SSC-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-SSC-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-SSC-6803529, FGFR2 alternative splicing
R-SSC-6807505, RNA polymerase II transcribes snRNA genes
R-SSC-72086, mRNA Capping
R-SSC-72163, mRNA Splicing - Major Pathway
R-SSC-72165, mRNA Splicing - Minor Pathway
R-SSC-72203, Processing of Capped Intron-Containing Pre-mRNA
R-SSC-73776, RNA Polymerase II Promoter Escape
R-SSC-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SSC-75953, RNA Polymerase II Transcription Initiation
R-SSC-75955, RNA Polymerase II Transcription Elongation
R-SSC-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SSC-77075, RNA Pol II CTD phosphorylation and interaction with CE
R-SSC-9018519, Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation (EC:2.7.7.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLR2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:91646, POLR2A

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotationARBA annotation, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
I3LJR4

PeptideAtlas

More...
PeptideAtlasi
I3LJR4

PRoteomics IDEntifications database

More...
PRIDEi
I3LJR4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000028278, Expressed in oocyte and 47 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000024326

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
I3LJR4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini246 – 530RPOLA_NInterPro annotationAdd BLAST285

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1518 – 1942DisorderedSequence analysisAdd BLAST425

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili680 – 700Sequence analysisAdd BLAST21
Coiled coili930 – 950Sequence analysisAdd BLAST21
Coiled coili1243 – 1263Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1537 – 1556Pro residuesSequence analysisAdd BLAST20
Compositional biasi1579 – 1935Polar residuesSequence analysisAdd BLAST357

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0260, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00930000151033

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
I3LJR4

Identification of Orthologs from Complete Genome Data

More...
OMAi
LNNAIQM

TreeFam database of animal gene trees

More...
TreeFami
TF103036

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.30, 1 hit
1.10.274.100, 1 hit
3.30.1360.140, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000722, RNA_pol_asu
IPR000684, RNA_pol_II_repeat_euk
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR007075, RNA_pol_Rpb1_6
IPR007073, RNA_pol_Rpb1_7
IPR038593, RNA_pol_Rpb1_7_sf
IPR038120, Rpb1_funnel_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 1 hit
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit
PF04992, RNA_pol_Rpb1_6, 1 hit
PF04990, RNA_pol_Rpb1_7, 1 hit
PF05001, RNA_pol_Rpb1_R, 36 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00663, RPOLA_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00115, RNA_POL_II_REPEAT, 21 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

I3LJR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHGGGPPSGD SACPLRTIKR VQFGVLSPDE LKRMSVTEGG IKYPETTEGG
60 70 80 90 100
RPKLGGLMDP RQGVIERTGR CQTCAGNMTE CPGHFGHIEL AKPVFHVGFL
110 120 130 140 150
VKTMKVLRCV CFFCSKLLVD SNNPKIKDIL AKSKGQPKKR LTHVYDLCKG
160 170 180 190 200
KNICEGGEEM DNKFGVEQPE GDEDLTKEKG HGGCGRYQPR IRRSGLELYA
210 220 230 240 250
EWKHVNEDSQ EKKILLSPER VHEIFKRISD EECFVLGMEP RYARPEWMIV
260 270 280 290 300
TVLPVPPLSV RPAVVMQGSA RNQDDLTHKL ADIVKINNQL RRNEQNGAAA
310 320 330 340 350
HVIAEDVKLL QFHVATMVDN ELPGLPRAMQ KSGRPLKSLK QRLKGKEGRV
360 370 380 390 400
RGNLMGKRVD FSARTVITPD PNLSIDQVGV PRSIAANMTF AEIVTPFNID
410 420 430 440 450
RLQELVRRGN SQYPGAKYII RDNGDRIDLR FHPKPSDLHL QTGYKVERHM
460 470 480 490 500
CDGDIVIFNR QPTLHKMSMM GHRVRILPWS TFRLNLRSVH WLREAAGAGL
510 520 530 540 550
LPGDTGGDPG SNRPVMGIVQ DTLTAVRKFT KRDVFLERGE VMNLLMFLST
560 570 580 590 600
WDGKVPQPAI LKPRPLWTGK QIFSLIIPGH INCIRTHSTH PDDEDSGPYK
610 620 630 640 650
HISPGDTKVV VENGELIMGI LCKKSLGTSA GSLVHISYLE MGHDITRLFY
660 670 680 690 700
SNIQTVINNW LLIEGHTIGI GDSIADSKTY QDIQNTIKKA KQDVIEVIEK
710 720 730 740 750
AHNNELEPTP GNTLRQTFEN QVNRILNDAR DKTGSSAQKS LSEYNNFKSM
760 770 780 790 800
VVSGAKGSKI NISQVIAVVG QQNVEGKRIP FGFKHRTLPH FIKDDYGPES
810 820 830 840 850
RGFVENSYLA GLTPTEFFFH AMGGREGLID TAVKTAETGY IQRRLIKSME
860 870 880 890 900
SVMVKYDATV RNSINQVVQL RYGEDGLAGE SVEFQNLATL KPSNKAFEKK
910 920 930 940 950
FRFDYTNERA LRRTLQEDLV KDVLSNAHIQ NELEREFERM REDREVLRVI
960 970 980 990 1000
FPTGDSKVVL PCNLLRMIWN AQKIFHINPR LPSDLHPIKV VEGVKELSKK
1010 1020 1030 1040 1050
LVIVNGDDPL SRQAQENATL LFNIHLRSTL CSRRMAEEFR LSGEAFDWLL
1060 1070 1080 1090 1100
GEIESKFNQA IAHPGEMVGA LAAQSLGEPA TQMTLNTFHY AGVSAKNVTL
1110 1120 1130 1140 1150
GVPRLKELIN ISKKPKTPSL TVFLLGQSAR DAERAKDILC RLEHTTLRKV
1160 1170 1180 1190 1200
TANTAIYYDP NPQSTVVAED QEWVNVYYEM PDFDVARISP WLLRVELDRK
1210 1220 1230 1240 1250
HMTDRKLTME QIAEKINAGF GDDLNCIFND DNAEKLVLRI RIMNSDENKM
1260 1270 1280 1290 1300
QEEEEVVDKM DDDVFLRCIE SNMLTDMTLQ GSSRSTDNKK KIIITEDGEF
1310 1320 1330 1340 1350
KALQEWILET DGVSLMRVLS EKDVDPVRTT SNDIVEIFTV LGIEAVRKAL
1360 1370 1380 1390 1400
ERELYHVISF DGSYVNYRHL ALLCDTMTCR GHLMAITRHG VNRQDTGPLM
1410 1420 1430 1440 1450
KCSFEETVDV LMEAAAHGES DPMKGVSENI MLGQLAPAGT GCFDLLLDAE
1460 1470 1480 1490 1500
KCKYGMEIPT NIPGLGAAGP TGMFFGSAPS PMGGISPAMT PWNQGATPAY
1510 1520 1530 1540 1550
GAWSPSVGSG MTPGAAGFSP SAASDASGFS PGYSPAWSPT PGSPGSPGPS
1560 1570 1580 1590 1600
SPYIPSPGGA MSPSYSPTSP AYEPRSPGGY TPQSPSYSPT SPSYSPTSPS
1610 1620 1630 1640 1650
YSPTSPNYSP TSPSYSPTSP SYSPTSPSYS PTSPSYSPTS PSYSPTSPSY
1660 1670 1680 1690 1700
SPTSPSYSPT SPSYSPTSPS YSPTSPSYSP TSPSYSPTSP SYSPTSPSYS
1710 1720 1730 1740 1750
PTSPSYSPTS PSYSPTSPNY SPTSPNYTPT SPSYSPTSPS YSPTSPNYTP
1760 1770 1780 1790 1800
TSPNYSPTSP SYSPTSPSYS PTSPSYSPSS PRYTPQSPTY TPSSPSYSPS
1810 1820 1830 1840 1850
SPSYSPTSPK YTPTSPSYSP SSPEYTPTSP KYSPTSPKYS PTSPKYSPTS
1860 1870 1880 1890 1900
PTYSPTTPKY SPTSPTYSPT SPVYTPTSPK YSPTSPTYSP TSPKYSPTSP
1910 1920 1930 1940
TYSPTSPKGS TYSPTSPGYS PTSPTYSLTS PAISPDDSDE EN
Length:1,942
Mass (Da):213,586
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49BE60E8DC01D403
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5G2RA15A0A5G2RA15_PIG
DNA-directed RNA polymerase subunit
POLR2A
566Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEMK02000082 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000029425; ENSSSCP00000024326; ENSSSCG00000028278

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000082 Genomic DNA No translation available.

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EXVelectron microscopy3.60A1-1279[»]
A1281-1942[»]
6GMHelectron microscopy3.10A1-1942[»]
6GMLelectron microscopy3.20A1-1942[»]
7B7Uelectron microscopy2.80A1-500[»]
A502-1281[»]
A1283-1942[»]
SMRiI3LJR4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024326

Proteomic databases

PaxDbiI3LJR4
PeptideAtlasiI3LJR4
PRIDEiI3LJR4

Genome annotation databases

EnsembliENSSSCT00000029425; ENSSSCP00000024326; ENSSSCG00000028278

Organism-specific databases

VGNCiVGNC:91646, POLR2A

Phylogenomic databases

eggNOGiKOG0260, Eukaryota
GeneTreeiENSGT00930000151033
InParanoidiI3LJR4
OMAiLNNAIQM
TreeFamiTF103036

Enzyme and pathway databases

ReactomeiR-SSC-112382, Formation of RNA Pol II elongation complex
R-SSC-113418, Formation of the Early Elongation Complex
R-SSC-5578749, Transcriptional regulation by small RNAs
R-SSC-674695, RNA Polymerase II Pre-transcription Events
R-SSC-6781823, Formation of TC-NER Pre-Incision Complex
R-SSC-6782135, Dual incision in TC-NER
R-SSC-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-SSC-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-SSC-6803529, FGFR2 alternative splicing
R-SSC-6807505, RNA polymerase II transcribes snRNA genes
R-SSC-72086, mRNA Capping
R-SSC-72163, mRNA Splicing - Major Pathway
R-SSC-72165, mRNA Splicing - Minor Pathway
R-SSC-72203, Processing of Capped Intron-Containing Pre-mRNA
R-SSC-73776, RNA Polymerase II Promoter Escape
R-SSC-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SSC-75953, RNA Polymerase II Transcription Initiation
R-SSC-75955, RNA Polymerase II Transcription Elongation
R-SSC-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SSC-77075, RNA Pol II CTD phosphorylation and interaction with CE
R-SSC-9018519, Estrogen-dependent gene expression

Gene expression databases

BgeeiENSSSCG00000028278, Expressed in oocyte and 47 other tissues

Family and domain databases

Gene3Di1.10.132.30, 1 hit
1.10.274.100, 1 hit
3.30.1360.140, 1 hit
InterProiView protein in InterPro
IPR000722, RNA_pol_asu
IPR000684, RNA_pol_II_repeat_euk
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR007075, RNA_pol_Rpb1_6
IPR007073, RNA_pol_Rpb1_7
IPR038593, RNA_pol_Rpb1_7_sf
IPR038120, Rpb1_funnel_sf
PfamiView protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 1 hit
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit
PF04992, RNA_pol_Rpb1_6, 1 hit
PF04990, RNA_pol_Rpb1_7, 1 hit
PF05001, RNA_pol_Rpb1_R, 36 hits
SMARTiView protein in SMART
SM00663, RPOLA_N, 1 hit
PROSITEiView protein in PROSITE
PS00115, RNA_POL_II_REPEAT, 21 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3LJR4_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3LJR4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: December 11, 2019
Last modified: September 29, 2021
This is version 62 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Proteomics identificationCombined sources, Reference proteomeImported
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