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Protein
Submitted name:

Uncharacterized protein

Gene

KRAS

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SSC-1169092 Activation of RAS in B cells
R-SSC-1250347 SHC1 events in ERBB4 signaling
R-SSC-1433557 Signaling by SCF-KIT
R-SSC-171007 p38MAPK events
R-SSC-179812 GRB2 events in EGFR signaling
R-SSC-180336 SHC1 events in EGFR signaling
R-SSC-186763 Downstream signal transduction
R-SSC-1963640 GRB2 events in ERBB2 signaling
R-SSC-210993 Tie2 Signaling
R-SSC-2179392 EGFR Transactivation by Gastrin
R-SSC-2424491 DAP12 signaling
R-SSC-2871796 FCERI mediated MAPK activation
R-SSC-375165 NCAM signaling for neurite out-growth
R-SSC-5218921 VEGFR2 mediated cell proliferation
R-SSC-5621575 CD209 (DC-SIGN) signaling
R-SSC-5654688 SHC-mediated cascade:FGFR1
R-SSC-5654693 FRS-mediated FGFR1 signaling
R-SSC-5654699 SHC-mediated cascade:FGFR2
R-SSC-5654700 FRS-mediated FGFR2 signaling
R-SSC-5654704 SHC-mediated cascade:FGFR3
R-SSC-5654706 FRS-mediated FGFR3 signaling
R-SSC-5654712 FRS-mediated FGFR4 signaling
R-SSC-5654719 SHC-mediated cascade:FGFR4
R-SSC-5658442 Regulation of RAS by GAPs
R-SSC-5673000 RAF activation
R-SSC-5673001 RAF/MAP kinase cascade
R-SSC-5674135 MAP2K and MAPK activation
R-SSC-5675221 Negative regulation of MAPK pathway
R-SSC-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-SSC-8851805 MET activates RAS signaling
R-SSC-8951936 RUNX3 regulates p14-ARF

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:KRASImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 5

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiI3LCQ9
PeptideAtlasiI3LCQ9
PRIDEiI3LCQ9

Expressioni

Gene expression databases

BgeeiENSSSCG00000026969 Expressed in 5 organ(s), highest expression level in heart
ExpressionAtlasiI3LCQ9 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021836

Structurei

3D structure databases

ProteinModelPortaliI3LCQ9
SMRiI3LCQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
InParanoidiI3LCQ9
KOiK07827
OrthoDBiEOG091G0UAU
TreeFamiTF312796

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

I3LCQ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI
110 120 130 140 150
KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QDLARSYGIP FIETSAKTRQ
160 170 180
GVDDAFYTLV REIRKHKEKM SKDGKKKKKK SKTKCIIM
Length:188
Mass (Da):21,439
Last modified:November 22, 2017 - v2
Checksum:iB1B6C319BB259861
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A287B854A0A287B854_PIG
Uncharacterized protein
KRAS
189Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000034 Genomic DNA No translation available.
RefSeqiXP_003126475.1, XM_003126427.4
XP_005653209.1, XM_005653152.2
UniGeneiSsc.30458

Genome annotation databases

EnsembliENSSSCT00000025989; ENSSSCP00000021836; ENSSSCG00000026969
GeneIDi100518251
KEGGissc:100518251

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000034 Genomic DNA No translation available.
RefSeqiXP_003126475.1, XM_003126427.4
XP_005653209.1, XM_005653152.2
UniGeneiSsc.30458

3D structure databases

ProteinModelPortaliI3LCQ9
SMRiI3LCQ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021836

Proteomic databases

PaxDbiI3LCQ9
PeptideAtlasiI3LCQ9
PRIDEiI3LCQ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000025989; ENSSSCP00000021836; ENSSSCG00000026969
GeneIDi100518251
KEGGissc:100518251

Organism-specific databases

CTDi3845

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
InParanoidiI3LCQ9
KOiK07827
OrthoDBiEOG091G0UAU
TreeFamiTF312796

Enzyme and pathway databases

ReactomeiR-SSC-1169092 Activation of RAS in B cells
R-SSC-1250347 SHC1 events in ERBB4 signaling
R-SSC-1433557 Signaling by SCF-KIT
R-SSC-171007 p38MAPK events
R-SSC-179812 GRB2 events in EGFR signaling
R-SSC-180336 SHC1 events in EGFR signaling
R-SSC-186763 Downstream signal transduction
R-SSC-1963640 GRB2 events in ERBB2 signaling
R-SSC-210993 Tie2 Signaling
R-SSC-2179392 EGFR Transactivation by Gastrin
R-SSC-2424491 DAP12 signaling
R-SSC-2871796 FCERI mediated MAPK activation
R-SSC-375165 NCAM signaling for neurite out-growth
R-SSC-5218921 VEGFR2 mediated cell proliferation
R-SSC-5621575 CD209 (DC-SIGN) signaling
R-SSC-5654688 SHC-mediated cascade:FGFR1
R-SSC-5654693 FRS-mediated FGFR1 signaling
R-SSC-5654699 SHC-mediated cascade:FGFR2
R-SSC-5654700 FRS-mediated FGFR2 signaling
R-SSC-5654704 SHC-mediated cascade:FGFR3
R-SSC-5654706 FRS-mediated FGFR3 signaling
R-SSC-5654712 FRS-mediated FGFR4 signaling
R-SSC-5654719 SHC-mediated cascade:FGFR4
R-SSC-5658442 Regulation of RAS by GAPs
R-SSC-5673000 RAF activation
R-SSC-5673001 RAF/MAP kinase cascade
R-SSC-5674135 MAP2K and MAPK activation
R-SSC-5675221 Negative regulation of MAPK pathway
R-SSC-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-SSC-8851805 MET activates RAS signaling
R-SSC-8951936 RUNX3 regulates p14-ARF

Gene expression databases

BgeeiENSSSCG00000026969 Expressed in 5 organ(s), highest expression level in heart
ExpressionAtlasiI3LCQ9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI3LCQ9_PIG
AccessioniPrimary (citable) accession number: I3LCQ9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: November 22, 2017
Last modified: November 7, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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