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Protein

Pyruvate kinase

Gene

PKLR

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (GAPDHS), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
  2. Phosphoglycerate kinase (PGK2), Phosphoglycerate kinase (PGK2), Phosphoglycerate kinase (PGK1), Phosphoglycerate kinase 2 (PGK2), Phosphoglycerate kinase 1 (PGK1), Phosphoglycerate kinase (PGK1), Phosphoglycerate kinase (PGK2), Phosphoglycerate kinase (PGK1), Phosphoglycerate kinase (PGK2)
  3. no protein annotated in this organism
  4. Beta-enolase (ENO3)
  5. Pyruvate kinase (PKLR), Pyruvate kinase (PKM), Pyruvate kinase (PKM), Pyruvate kinase (PKM), Pyruvate kinase (PKLR), Pyruvate kinase (PKLR), Pyruvate kinase (PKM)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation

Enzyme and pathway databases

ReactomeiR-SSC-70171 Glycolysis
UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:PKLRImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 4

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiI3LAK4
PeptideAtlasiI3LAK4
PRIDEiI3LAK4

Expressioni

Gene expression databases

BgeeiENSSSCG00000026149

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021072

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 373PKInterPro annotationAdd BLAST352
Domaini390 – 507PK_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323 Eukaryota
COG0469 LUCA
GeneTreeiENSGT00390000008859
InParanoidiI3LAK4
OrthoDBiEOG091G0597
TreeFamiTF300390

Family and domain databases

CDDicd00288 Pyruvate_Kinase, 1 hit
Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 2 hits
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

I3LAK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSFLEHLC LLDIDSEPVA ARSTSIIATI GPASRSVERL KEMIKAGMNI
60 70 80 90 100
ARLNFSHGSH EYHAESIANI REAVESFAGS PLIYRPVAIA LDTKGPEIRT
110 120 130 140 150
GIPQGGPTSE VELVKGSRVL VTVDPAFQKL GNATTVWVDY PNIIRVVPVG
160 170 180 190 200
GRIYIDDGLI SLVVTKIGPE GLETQVESGG VLGSRKGVNL PGTQVDLPGL
210 220 230 240 250
SEQDIQDLQF GVEHGVDIIF ASFVRKASDV AAVRAALGPE GQGIKIISKI
260 270 280 290 300
ENHEGVKKFD EILEVSDGIM VARGDLGIEI PAEKVFLAQK MMIGRCNLAG
310 320 330 340 350
KPVVCATQML ESMITKPRPT RAETSDVANA VLDGADCIML SGETAKGHFP
360 370 380 390 400
VEAVKMQHAI AREAEAAVYH RQLFEELRRA APLSRDPTEV TAIGAVEASF
410 420 430 440 450
KCCAAAIIVL TKTGRSAQLL SRYRPRAAVI AVTRSAQAAR QAHLCRGVFP
460 470 480 490 500
VLYREPPEDI WADDVDRRVQ FGIESGKLRG FLRLGDLVIV VTGWRPGSGY
510
TNIMRVLSIT
Length:510
Mass (Da):54,937
Last modified:November 22, 2017 - v2
Checksum:i5AD1C2D5D13B2FB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000022 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSSSCT00000031891; ENSSSCP00000021072; ENSSSCG00000026149

Similar proteinsi

Entry informationi

Entry nameiI3LAK4_PIG
AccessioniPrimary (citable) accession number: I3LAK4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: November 22, 2017
Last modified: March 28, 2018
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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