Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Unconventional myosin-Ic

Gene

MYO1C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi118 – 125ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Unconventional myosin-IcImported
Gene namesi
Name:MYO1CImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000197879.14
HGNCiHGNC:7597 MYO1C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197879

PTM / Processingi

Proteomic databases

EPDiI3L501
PeptideAtlasiI3L501
PRIDEiI3L501

Expressioni

Gene expression databases

BgeeiENSG00000197879 Expressed in 236 organ(s), highest expression level in subcutaneous adipose tissue
ExpressionAtlasiI3L501 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliI3L501
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 168Myosin motorInterPro annotationAdd BLAST144

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150810

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

I3L501-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPCALGSDGV RVTMESALTA RDRVGVQDFV LLENFTSEAA FIENLRRRFR
60 70 80 90 100
ENLIYTYIGP VLVSVNPYRD LQIYSRQHME RYRGVSFYEV PPHLFAVADT
110 120 130 140 150
VYRALRTERR DQAVMISGES GAGKTEATKR LLQFYAETCP APERGGAVRD
160
RLLQSNPVLE AFGNAKTL
Length:168
Mass (Da):18,996
Last modified:October 5, 2016 - v8
Checksum:i7B4B0D8B86C939F2
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O00159MYO1C_HUMAN
Unconventional myosin-Ic
MYO1C
1,063Annotation score:
F5H6E2F5H6E2_HUMAN
Unconventional myosin-Ic
MYO1C
1,039Annotation score:
I3L3Y6I3L3Y6_HUMAN
Unconventional myosin-Ic
MYO1C
170Annotation score:
I3L204I3L204_HUMAN
Unconventional myosin-Ic
MYO1C
267Annotation score:
I3L3F5I3L3F5_HUMAN
Unconventional myosin-Ic
MYO1C
137Annotation score:
I3L2C3I3L2C3_HUMAN
Unconventional myosin-Ic
MYO1C
65Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei168Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100748 Genomic DNA No translation available.
KF459568 Genomic DNA No translation available.
KF495829 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000570490; ENSP00000461682; ENSG00000197879
UCSCiuc059zfn.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100748 Genomic DNA No translation available.
KF459568 Genomic DNA No translation available.
KF495829 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliI3L501
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiI3L501
PeptideAtlasiI3L501
PRIDEiI3L501

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000570490; ENSP00000461682; ENSG00000197879
UCSCiuc059zfn.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000197879.14
HGNCiHGNC:7597 MYO1C
OpenTargetsiENSG00000197879
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150810

Miscellaneous databases

ChiTaRSiMYO1C human

Gene expression databases

BgeeiENSG00000197879 Expressed in 236 organ(s), highest expression level in subcutaneous adipose tissue
ExpressionAtlasiI3L501 baseline and differential

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI3L501_HUMAN
AccessioniPrimary (citable) accession number: I3L501
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: October 5, 2016
Last modified: November 7, 2018
This is version 51 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again