UniProtKB - I3L4X6 (I3L4X6_HUMAN)
Protein
Submitted name:
Solute carrier family 13 member 5
Gene
SLC13A5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- sodium ion transport Source: UniProtKB-KW
Keywordsi
Biological process | Ion transport, Sodium transportARBA annotation, Transport |
Ligand | Sodium |
Names & Taxonomyi
Protein namesi | Submitted name: Solute carrier family 13 member 5Imported |
Gene namesi | Name:SLC13A5Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000141485.16 |
HGNCi | HGNC:23089, SLC13A5 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 31 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 51 – 68 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 89 – 112 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Proteomic databases
MaxQBi | I3L4X6 |
PeptideAtlasi | I3L4X6 |
PRIDEi | I3L4X6 |
ProteomicsDBi | 47622 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141485, Expressed in parotid gland and 109 other tissues |
ExpressionAtlasi | I3L4X6, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT01000000214573 |
HOGENOMi | CLU_1598264_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR001898, SLC13A/DASS |
Pfami | View protein in Pfam PF00939, Na_sulph_symp, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
I3L4X6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASALSYVSK FKSFVILFVT PLLLLPLVIL MPAKILDSRQ VCVQYMKDTN
60 70 80 90 100
MLFLGGLIVA VAVERWNLHK RIALRTLLWV GAKPARLMLG FMGVTALLSM
110 120 130 140 150
WISNTATTAM MVPIVEAILQ QMEATSAATE AGLELVDKGK AKELPGSQVI
160
FEGPTLGQQE DQERKRL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ86YT5 | S13A5_HUMAN | Solute carrier family 13 member 5 | SLC13A5 NACT | 568 | Annotation score: | ||
I3L2Y7 | I3L2Y7_HUMAN | Solute carrier family 13 member 5 | SLC13A5 | 94 | Annotation score: | ||
I3L424 | I3L424_HUMAN | Solute carrier family 13 member 5 | SLC13A5 | 91 | Annotation score: | ||
I3L4S9 | I3L4S9_HUMAN | Solute carrier family 13 member 5 | SLC13A5 | 81 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 167 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004706 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000572352; ENSP00000461622; ENSG00000141485 |
UCSCi | uc060afe.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004706 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | I3L4X6 |
PeptideAtlasi | I3L4X6 |
PRIDEi | I3L4X6 |
ProteomicsDBi | 47622 |
Protocols and materials databases
Antibodypediai | 23824, 114 antibodies |
Genome annotation databases
Ensembli | ENST00000572352; ENSP00000461622; ENSG00000141485 |
UCSCi | uc060afe.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000141485.16 |
HGNCi | HGNC:23089, SLC13A5 |
OpenTargetsi | ENSG00000141485 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01000000214573 |
HOGENOMi | CLU_1598264_0_0_1 |
Miscellaneous databases
ChiTaRSi | SLC13A5, human |
Gene expression databases
Bgeei | ENSG00000141485, Expressed in parotid gland and 109 other tissues |
ExpressionAtlasi | I3L4X6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001898, SLC13A/DASS |
Pfami | View protein in Pfam PF00939, Na_sulph_symp, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I3L4X6_HUMAN | |
Accessioni | I3L4X6Primary (citable) accession number: I3L4X6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | July 11, 2012 | |
Last modified: | December 2, 2020 | |
This is version 42 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |