UniProtKB - I3L3U8 (I3L3U8_HUMAN)
Protein
Submitted name:
Lipopolysaccharide-induced tumor necrosis factor-alpha factor
Gene
LITAF
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
Keywordsi
Ligand | Metal-bindingARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Lipopolysaccharide-induced tumor necrosis factor-alpha factorImported |
Gene namesi | Name:LITAFImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16841, LITAF |
VEuPathDBi | HostDB:ENSG00000189067.12 |
Subcellular locationi
Lysosome
- Lysosome membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Endosome
- Endosome membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Other locations
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Cytosol
- cytosol Source: HPA
Endosome
- endosome membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Nucleus
- nucleoplasm Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
MembraneARBA annotationPTM / Processingi
Proteomic databases
PeptideAtlasi | I3L3U8 |
ProteomicsDBi | 47325 |
PTM databases
SwissPalmi | I3L3U8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000189067, Expressed in epithelium of bronchus and 250 other tissues |
ExpressionAtlasi | I3L3U8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 76 – 153 | LITAFInterPro annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 7 – 22 | PolarSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the CDIP1/LITAF family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000155366 |
HOGENOMi | CLU_095549_5_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR006629, LITAF IPR037519, LITAF_fam |
PANTHERi | PTHR23292, PTHR23292, 1 hit |
Pfami | View protein in Pfam PF10601, zf-LITAF-like, 1 hit |
SMARTi | View protein in SMART SM00714, LITAF, 1 hit |
PROSITEi | View protein in PROSITE PS51837, LITAF, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
I3L3U8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVPGPYQAA TGPSSAPSAP PSYEETVAVN SYYPTPPAPM PGPTTGLVTG
60 70 80 90 100
PDGKGMNPPS YYTQPAPIPN NNPITVQTVY VQHPITFLDR PIQMCCPSCN
110 120 130 140 150
KMIVSQLSYN AGALTWLSCG SLCLLGCIAG CCFIPFCVDA LQDVDHYCPN
CRA
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ99732 | LITAF_HUMAN | Lipopolysaccharide-induced tumor ne... | LITAF PIG7, SIMPLE | 161 | Annotation score: | ||
I3L1I9 | I3L1I9_HUMAN | Lipopolysaccharide-induced tumor ne... | LITAF | 137 | Annotation score: | ||
I3L1P1 | I3L1P1_HUMAN | Lipopolysaccharide-induced tumor ne... | LITAF | 136 | Annotation score: | ||
I3L329 | I3L329_HUMAN | Lipopolysaccharide-induced tumor ne... | LITAF | 126 | Annotation score: | ||
I3L1H3 | I3L1H3_HUMAN | Lipopolysaccharide-induced tumor ne... | LITAF | 68 | Annotation score: | ||
I3L2T6 | I3L2T6_HUMAN | Lipopolysaccharide-induced tumor ne... | LITAF | 105 | Annotation score: | ||
I3L1R0 | I3L1R0_HUMAN | Lipopolysaccharide-induced tumor ne... | LITAF | 39 | Annotation score: | ||
I3L2T1 | I3L2T1_HUMAN | Lipopolysaccharide-induced tumor ne... | LITAF | 88 | Annotation score: | ||
I3L2E2 | I3L2E2_HUMAN | Lipopolysaccharide-induced tumor ne... | LITAF | 75 | Annotation score: | ||
I3L409 | I3L409_HUMAN | Lipopolysaccharide-induced tumor ne... | LITAF | 81 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 153 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007616 Genomic DNA No translation available. AC099489 Genomic DNA No translation available. KF456159 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000571627; ENSP00000460743; ENSG00000189067 |
UCSCi | uc059qvq.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007616 Genomic DNA No translation available. AC099489 Genomic DNA No translation available. KF456159 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
SwissPalmi | I3L3U8 |
Proteomic databases
PeptideAtlasi | I3L3U8 |
ProteomicsDBi | 47325 |
Protocols and materials databases
Antibodypediai | 1839, 286 antibodies |
Genome annotation databases
Ensembli | ENST00000571627; ENSP00000460743; ENSG00000189067 |
UCSCi | uc059qvq.1, human |
Organism-specific databases
HGNCi | HGNC:16841, LITAF |
OpenTargetsi | ENSG00000189067 |
VEuPathDBi | HostDB:ENSG00000189067.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155366 |
HOGENOMi | CLU_095549_5_0_1 |
Miscellaneous databases
ChiTaRSi | LITAF, human |
Gene expression databases
Bgeei | ENSG00000189067, Expressed in epithelium of bronchus and 250 other tissues |
ExpressionAtlasi | I3L3U8, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR006629, LITAF IPR037519, LITAF_fam |
PANTHERi | PTHR23292, PTHR23292, 1 hit |
Pfami | View protein in Pfam PF10601, zf-LITAF-like, 1 hit |
SMARTi | View protein in SMART SM00714, LITAF, 1 hit |
PROSITEi | View protein in PROSITE PS51837, LITAF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I3L3U8_HUMAN | |
Accessioni | I3L3U8Primary (citable) accession number: I3L3U8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | October 5, 2016 | |
Last modified: | February 10, 2021 | |
This is version 52 of the entry and version 8 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |