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Protein

Eukaryotic translation initiation factor 5A

Gene

EIF5A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein biosynthesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5AUniRule annotation
Short name:
eIF-5AUniRule annotation
Gene namesi
Name:EIF5AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000132507.17
HGNCiHGNC:3300 EIF5A

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132507

PTM / Processingi

Post-translational modificationi

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).UniRule annotation

Keywords - PTMi

HypusineUniRule annotation

Proteomic databases

EPDiI3L397
PeptideAtlasiI3L397
PRIDEiI3L397

Expressioni

Gene expression databases

BgeeiENSG00000132507 Expressed in 218 organ(s), highest expression level in right testis
ExpressionAtlasiI3L397 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 146eIF-5aInterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the eIF-5A family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3271 Eukaryota
COG0231 LUCA
GeneTreeiENSGT00390000003738

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR001884 IF5A-like
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11673 PTHR11673, 1 hit
PfamiView protein in Pfam
PF01287 eIF-5a, 1 hit
PIRSFiPIRSF003025 eIF5A, 1 hit
SMARTiView protein in SMART
SM01376 eIF-5a, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00037 eIF_5A, 1 hit
PROSITEiView protein in PROSITE
PS00302 IF5A_HYPUSINE, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

I3L397-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK
60 70 80 90 100
HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS
110 120 130 140
LLQDSGEVRE DLRLPEGDLG KEIEQKYDCG EEILITVLSA MTEEAA
Length:146
Mass (Da):16,019
Last modified:October 5, 2016 - v8
Checksum:i9EB5D839F5D69AC5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P63241IF5A1_HUMAN
Eukaryotic translation initiation f...
EIF5A
154Annotation score:
I3L504I3L504_HUMAN
Eukaryotic translation initiation f...
EIF5A
186Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei146Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026954 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000573714; ENSP00000460284; ENSG00000132507
UCSCiuc060amn.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026954 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiI3L397
PeptideAtlasiI3L397
PRIDEiI3L397

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000573714; ENSP00000460284; ENSG00000132507
UCSCiuc060amn.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000132507.17
HGNCiHGNC:3300 EIF5A
OpenTargetsiENSG00000132507
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3271 Eukaryota
COG0231 LUCA
GeneTreeiENSGT00390000003738

Miscellaneous databases

ChiTaRSiEIF5A human

Gene expression databases

BgeeiENSG00000132507 Expressed in 218 organ(s), highest expression level in right testis
ExpressionAtlasiI3L397 baseline and differential

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR001884 IF5A-like
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11673 PTHR11673, 1 hit
PfamiView protein in Pfam
PF01287 eIF-5a, 1 hit
PIRSFiPIRSF003025 eIF5A, 1 hit
SMARTiView protein in SMART
SM01376 eIF-5a, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00037 eIF_5A, 1 hit
PROSITEiView protein in PROSITE
PS00302 IF5A_HYPUSINE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI3L397_HUMAN
AccessioniPrimary (citable) accession number: I3L397
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 47 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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