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Entry version 49 (02 Jun 2021)
Sequence version 1 (11 Jul 2012)
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Protein
Submitted name:

Neuralized-like protein 4

Gene

NEURL4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Neuralized-like protein 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEURL4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:34410, NEURL4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000215041.9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000215041

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
I3L2Z9

PeptideAtlas

More...
PeptideAtlasi
I3L2Z9

PRoteomics IDEntifications database

More...
PRIDEi
I3L2Z9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
47084

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000215041, Expressed in adult mammalian kidney and 183 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
I3L2Z9, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 229NHRInterPro annotationAdd BLAST168
Domaini265 – 431NHRInterPro annotationAdd BLAST167
Domaini461 – 629NHRInterPro annotationAdd BLAST169
Domaini658 – 831NHRInterPro annotationAdd BLAST174
Domaini876 – 1017NHRInterPro annotationAdd BLAST142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni31 – 52DisorderedSequence analysisAdd BLAST22
Regioni436 – 461DisorderedSequence analysisAdd BLAST26
Regioni831 – 868DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi444 – 459Polar residuesSequence analysisAdd BLAST16
Compositional biasi831 – 849Polar residuesSequence analysisAdd BLAST19

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159866

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002040_0_0_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR037962, Neuralized
IPR006573, NHR_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12429, PTHR12429, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07177, Neuralized, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00588, NEUZ, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51065, NHR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

I3L2Z9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EPLAPTEDSA LAEQGTSADE AFMVSPAQAR PETFPNSLES HNGEGLGSSG
60 70 80 90 100
AATSPILTSN DALLFHEKCG TLIKLSNNNK TAERRRPLDE FNNGVVMTNR
110 120 130 140 150
PLRDNEMFEI RIDKLVDKWS GSIEIGVTTH NPNSLEYPAT MTNLQSGTIM
160 170 180 190 200
MSGCGILTNG KGTRREYCEF SLDELQEGDH IGLTRKSNSA LHFFINGIDQ
210 220 230 240 250
GVATPLTPPV VYGVVDLYGM AVKVTIVHNN NHSDRLRRNN AILRALSPEG
260 270 280 290 300
ALRRAAPAAQ AEPERLLFHP NCGQKAAITH EGRTALRPHA TDDFNHGVVL
310 320 330 340 350
SSRALRDGEV FQVRIDKMVD KWAGSIEIGV TTHNPAYLQL PSTMTNLRSG
360 370 380 390 400
TWMMTGNGVM HNGTTILDEY GHNLDRLKAG DTVGVVRRED GTLHFFVNGM
410 420 430 440 450
TQGPAAWNVP PGVYAVVDLY GQAAQATIVD DVEVAPVPEP LPEGNNQVSP
460 470 480 490 500
SSPSSGAGGS DLRFHQLHGS NAVITNGGRT ALRHNCRSEF NDAIVISNRA
510 520 530 540 550
LRDGELFEIV IQKMVDRWSG SIEAGVTAIR PEDLEFPNTM TDIDYDTWML
560 570 580 590 600
SGTAIMQDGN TMRNNYGCDL DALGTGARIG MMRTAKGDLH YFINGQDQGA
610 620 630 640 650
ACSGLPPGKE VYAVVDLYGQ CVQVSITNAT GPMDNSLATS NTATEKSFPL
660 670 680 690 700
HSPVAGVAHR FHSTCGKNVT LEEDGTRAVR AAGYAHGLVF STKELRAEEV
710 720 730 740 750
FEVKVEELDE KWAGSLRLGL TTLAPGEMGP GAGGGGPGLP PSLPELRTKT
760 770 780 790 800
TWMVSSCEVR RDGQLQRMNY GRNLERLGVG SRVGVRRGAD DTMHILVDGE
810 820 830 840 850
DMGPAATGIA KNVWAVLDLY GPVRGVSIVS STRLEESEGT QPPSPSSDTG
860 870 880 890 900
SEGEEDDEGE EHGLGGQNEV GIIPTTLEFL ENHGKNILLS NGNRTATRVA
910 920 930 940 950
SYNQGIVVIN QPLVPQLLVQ VRIDFLNRQW TSSLVLGVIT CAPERLNFPA
960 970 980 990 1000
SACALKRAAW LLRGRGVFHN GLKPVSPPRS ARSLGPIWTR ALKAPSWDCG
1010
WTALGGCIFM LMGWTRG
Length:1,017
Mass (Da):109,656
Last modified:July 11, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i654545D43E50CFAF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96JN8NEUL4_HUMAN
Neuralized-like protein 4
NEURL4 KIAA1787
1,562Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L100I3L100_HUMAN
Neuralized-like protein 4
NEURL4
1,430Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2W2I3L2W2_HUMAN
Neuralized-like protein 4
NEURL4
1,538Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPS7K7EPS7_HUMAN
Neuralized-like protein 4
NEURL4
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC026954 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000573186; ENSP00000460062; ENSG00000215041

UCSC genome browser

More...
UCSCi
uc060ane.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026954 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiI3L2Z9
PeptideAtlasiI3L2Z9
PRIDEiI3L2Z9
ProteomicsDBi47084

Genome annotation databases

EnsembliENST00000573186; ENSP00000460062; ENSG00000215041
UCSCiuc060ane.1, human

Organism-specific databases

HGNCiHGNC:34410, NEURL4
OpenTargetsiENSG00000215041
VEuPathDBiHostDB:ENSG00000215041.9

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000159866
HOGENOMiCLU_002040_0_0_1

Gene expression databases

BgeeiENSG00000215041, Expressed in adult mammalian kidney and 183 other tissues
ExpressionAtlasiI3L2Z9, baseline and differential

Family and domain databases

Gene3Di2.60.120.920, 5 hits
InterProiView protein in InterPro
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR037962, Neuralized
IPR006573, NHR_dom
PANTHERiPTHR12429, PTHR12429, 1 hit
PfamiView protein in Pfam
PF07177, Neuralized, 5 hits
SMARTiView protein in SMART
SM00588, NEUZ, 5 hits
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51065, NHR, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3L2Z9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3L2Z9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: June 2, 2021
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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