UniProtKB - I3L2Y7 (I3L2Y7_HUMAN)
Protein
Submitted name:
Solute carrier family 13 member 5
Gene
SLC13A5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- sodium ion transport Source: UniProtKB-KW
Keywordsi
Biological process | Ion transport, Sodium transportARBA annotation, Transport |
Ligand | Sodium |
Names & Taxonomyi
Protein namesi | Submitted name: Solute carrier family 13 member 5Imported |
Gene namesi | Name:SLC13A5Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23089, SLC13A5 |
VEuPathDBi | HostDB:ENSG00000141485.16 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 45 – 64 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5003674936 | 20 – 94 | Sequence analysisAdd BLAST | 75 |
Proteomic databases
ProteomicsDBi | 47075 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141485, Expressed in parotid gland and 109 other tissues |
ExpressionAtlasi | I3L2Y7, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]ARBA annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT01000000214573 |
HOGENOMi | CLU_2405039_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR031312, Na/sul_symport_CS IPR001898, SLC13A/DASS |
Pfami | View protein in Pfam PF00939, Na_sulph_symp, 1 hit |
PROSITEi | View protein in PROSITE PS01271, NA_SULFATE, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
I3L2Y7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XPAAITLILS LLVAVFTECT SNVATTTLFL PIFASMSRSI GLNPLYIMLP
60 70 80 90
CTLSASFAFM LPVATPPNAI VFTYGHLKVA DMVTQLFLFT PVGL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ86YT5 | S13A5_HUMAN | Solute carrier family 13 member 5 | SLC13A5 NACT | 568 | Annotation score: | ||
I3L4X6 | I3L4X6_HUMAN | Solute carrier family 13 member 5 | SLC13A5 | 167 | Annotation score: | ||
I3L424 | I3L424_HUMAN | Solute carrier family 13 member 5 | SLC13A5 | 91 | Annotation score: | ||
I3L4S9 | I3L4S9_HUMAN | Solute carrier family 13 member 5 | SLC13A5 | 81 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004706 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000570687; ENSP00000460037; ENSG00000141485 |
UCSCi | uc060afb.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004706 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
ProteomicsDBi | 47075 |
Protocols and materials databases
Antibodypediai | 23824, 115 antibodies |
Genome annotation databases
Ensembli | ENST00000570687; ENSP00000460037; ENSG00000141485 |
UCSCi | uc060afb.1, human |
Organism-specific databases
HGNCi | HGNC:23089, SLC13A5 |
OpenTargetsi | ENSG00000141485 |
VEuPathDBi | HostDB:ENSG00000141485.16 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01000000214573 |
HOGENOMi | CLU_2405039_0_0_1 |
Miscellaneous databases
ChiTaRSi | SLC13A5, human |
Gene expression databases
Bgeei | ENSG00000141485, Expressed in parotid gland and 109 other tissues |
ExpressionAtlasi | I3L2Y7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR031312, Na/sul_symport_CS IPR001898, SLC13A/DASS |
Pfami | View protein in Pfam PF00939, Na_sulph_symp, 1 hit |
PROSITEi | View protein in PROSITE PS01271, NA_SULFATE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I3L2Y7_HUMAN | |
Accessioni | I3L2Y7Primary (citable) accession number: I3L2Y7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | July 11, 2012 | |
Last modified: | February 10, 2021 | |
This is version 36 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |