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Entry version 55 (02 Jun 2021)
Sequence version 1 (11 Jul 2012)
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Protein
Submitted name:

Neuralized-like protein 4

Gene

NEURL4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Neuralized-like protein 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEURL4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:34410, NEURL4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000215041.9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000215041

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
I3L2W2

PeptideAtlas

More...
PeptideAtlasi
I3L2W2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
47052

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000215041, Expressed in adult mammalian kidney and 183 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
I3L2W2, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
I3L2W2, 8 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 207NHRInterPro annotationAdd BLAST167
Domaini295 – 462NHRInterPro annotationAdd BLAST168
Domaini498 – 664NHRInterPro annotationAdd BLAST167
Domaini694 – 860NHRInterPro annotationAdd BLAST167
Domaini889 – 1062NHRInterPro annotationAdd BLAST174
Domaini1107 – 1270NHRInterPro annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 48DisorderedSequence analysisAdd BLAST48
Regioni207 – 237DisorderedSequence analysisAdd BLAST31
Regioni669 – 694DisorderedSequence analysisAdd BLAST26
Regioni1062 – 1099DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi207 – 225Pro residuesSequence analysisAdd BLAST19
Compositional biasi677 – 692Polar residuesSequence analysisAdd BLAST16
Compositional biasi1062 – 1080Polar residuesSequence analysisAdd BLAST19

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159866

Identification of Orthologs from Complete Genome Data

More...
OMAi
SNTEIEW

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR037962, Neuralized
IPR006573, NHR_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12429, PTHR12429, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07177, Neuralized, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00588, NEUZ, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51065, NHR, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

I3L2W2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGSGGSGG SGGGPGPGPG GGGGPSGSGS GPGSNGGLGS GGELHPRTGR
60 70 80 90 100
LVSLSACGRT ARRQQPGQEF NHGLVLSREP LRDGRVFTVR IDRKVNSWSG
110 120 130 140 150
SIEIGVTALD PSVLDFPSSA TGLKGGSWVV SGCSVLRDGR SVLEEYGQDL
160 170 180 190 200
DQLGEGDRVG VERTVAGELR LWVNGRDCGV AATGLPPRVW AVVDLYGKCT
210 220 230 240 250
QITVLPPEPG FSPPTPIPTP PLEPLAPTED SALAEQGTSA DEDFANMELS
260 270 280 290 300
EVVSNTILSA YNGGLLNVNL SSPPAGEGLG SSGAATSPIL TSNDALLFHE
310 320 330 340 350
KCGTLIKLSN NNKTAERRRP LDEFNNGVVM TNRPLRDNEM FEIRIDKLVD
360 370 380 390 400
KWSGSIEIGV TTHNPNSLEY PATMTNLQSG TIMMSGCGIL TNGKGTRREY
410 420 430 440 450
CEFSLDELQE GDHIGLTRKS NSALHFFING IDQGVATPLT PPVVYGVVDL
460 470 480 490 500
YGMAVKVTIV HNNNHSDRLR RNNAILRALS PEGALRRAAP AAQAEPERLL
510 520 530 540 550
FHPNCGQKAA ITHEGRTALR PHATDDFNHG VVLSSRALRD GEVFQVRIDK
560 570 580 590 600
MVDKWAGSIE IGVTTHNPAY LQLPSTMTNL RSGTWMMTGN GVMHNGTTIL
610 620 630 640 650
DEYGHNLDRL KAGDTVGVVR REDGTLHFFV NGMTQGPAAW NVPPGVYAVV
660 670 680 690 700
DLYGQAAQAT IVDDVEVAPV PEPLPEGNNQ VSPSSPSSGA GGSDLRFHQL
710 720 730 740 750
HGSNAVITNG GRTALRHNCR SEFNDAIVIS NRALRDGELF EIVIQKMVDR
760 770 780 790 800
WSGSIEAGVT AIRPEDLEFP NTMTDIDYDT WMLSGTAIMQ DGNTMRNNYG
810 820 830 840 850
CDLDALGTGA RIGMMRTAKG DLHYFINGQD QGAACSGLPP EVYAVVDLYG
860 870 880 890 900
QCVQVSITNA TGPMDNSLAT SNTATEKSFP LHSPVAGVAH RFHSTCGKNV
910 920 930 940 950
TLEEDGTRAV RAAGYAHGLV FSTKELRAEE VFEVKVEELD EKWAGSLRLG
960 970 980 990 1000
LTTLAPGEMG PGAGGGGPGL PPSLPELRTK TTWMVSSCEV RRDGQLQRMN
1010 1020 1030 1040 1050
YGRNLERLGV GSRVGVRRGA DDTMHILVDG EDMGPAATGI AKNVWAVLDL
1060 1070 1080 1090 1100
YGPVRGVSIV SSTRLEESEG TQPPSPSSDT GSEGEEDDEG EEHGLGGQNE
1110 1120 1130 1140 1150
VGIIPTTLEF LENHGKNILL SNGNRTATRV ASYNQGIVVI NQPLVPQLLV
1160 1170 1180 1190 1200
QVRIDFLNRQ WTSSLVLGVI TCAPERLNFP ASACALKRAA WLLRGRGVFH
1210 1220 1230 1240 1250
NGLKICEKFG PNLDTCPEGT ILGLRLDSSG GLHLHVNGVD QGVAVPDVPQ
1260 1270 1280 1290 1300
PCHALVDLYG QCEQVTIVNP EPGAASGKSA GTQGDMEKAD MVDGIKESVC
1310 1320 1330 1340 1350
WGPPPAASPL KSCEYHALCS RFQELLLLPE DYFMPPPKRS LCYCESCRKL
1360 1370 1380 1390 1400
RGDEAHRRRG EPPREYALPF GWCRFNLRVN PRLEAGTLTK KWHMAYHGSN
1410 1420 1430 1440 1450
VAAVRRVLDR GELGAGTASI LSCRPLKGEP GVGFEEPGEN CAPPREEQPP
1460 1470 1480 1490 1500
PVLLSPSLQY AGAETLASKV QFRDPKSQRT HQAQVAFQVC VRPGSYTPGP
1510 1520 1530
PSAALGEPPD PHFSPAELEW VTKEKGATLL CALLVRVE
Length:1,538
Mass (Da):164,309
Last modified:July 11, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DFF6DEAFA0E80D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96JN8NEUL4_HUMAN
Neuralized-like protein 4
NEURL4 KIAA1787
1,562Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L100I3L100_HUMAN
Neuralized-like protein 4
NEURL4
1,430Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2Z9I3L2Z9_HUMAN
Neuralized-like protein 4
NEURL4
1,017Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPS7K7EPS7_HUMAN
Neuralized-like protein 4
NEURL4
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC026954 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000570460; ENSP00000459978; ENSG00000215041

UCSC genome browser

More...
UCSCi
uc060anf.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026954 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiI3L2W2, 8 interactors

Proteomic databases

MaxQBiI3L2W2
PeptideAtlasiI3L2W2
ProteomicsDBi47052

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48206, 14 antibodies

Genome annotation databases

EnsembliENST00000570460; ENSP00000459978; ENSG00000215041
UCSCiuc060anf.1, human

Organism-specific databases

HGNCiHGNC:34410, NEURL4
OpenTargetsiENSG00000215041
VEuPathDBiHostDB:ENSG00000215041.9

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000159866
OMAiSNTEIEW

Gene expression databases

BgeeiENSG00000215041, Expressed in adult mammalian kidney and 183 other tissues
ExpressionAtlasiI3L2W2, baseline and differential

Family and domain databases

Gene3Di2.60.120.920, 6 hits
InterProiView protein in InterPro
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR037962, Neuralized
IPR006573, NHR_dom
PANTHERiPTHR12429, PTHR12429, 1 hit
PfamiView protein in Pfam
PF07177, Neuralized, 6 hits
SMARTiView protein in SMART
SM00588, NEUZ, 6 hits
SUPFAMiSSF49899, SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS51065, NHR, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3L2W2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3L2W2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: June 2, 2021
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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