UniProtKB - I3L2N2 (I3L2N2_HUMAN)
Protein
Submitted name:
Segment polarity protein dishevelled homolog DVL-2
Gene
DVL2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- intracellular signal transduction Source: InterPro
- multicellular organism development Source: UniProtKB-KW
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental proteinARBA annotation |
Biological process | Wnt signaling pathwayPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Segment polarity protein dishevelled homolog DVL-2Imported |
Gene namesi | Name:DVL2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3086, DVL2 |
VEuPathDBi | HostDB:ENSG00000004975.11 |
Subcellular locationi
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
Other locations
- aggresome Source: HPA
PTM / Processingi
Proteomic databases
MaxQBi | I3L2N2 |
PeptideAtlasi | I3L2N2 |
PRIDEi | I3L2N2 |
ProteomicsDBi | 46995 |
Expressioni
Gene expression databases
Bgeei | ENSG00000004975, Expressed in vagina and 229 other tissues |
ExpressionAtlasi | I3L2N2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 93 | DIXInterPro annotationAdd BLAST | 83 | |
Domaini | 261 – 333 | PDZInterPro annotationAdd BLAST | 73 | |
Domaini | 427 – 501 | DEPInterPro annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 92 – 248 | DisorderedSequence analysisAdd BLAST | 157 | |
Regioni | 552 – 669 | DisorderedSequence analysisAdd BLAST | 118 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 99 – 123 | Pro-richSequence analysisAdd BLAST | 25 | |
Compositional biasi | 135 – 168 | PolyampholyteSequence analysisAdd BLAST | 34 | |
Compositional biasi | 569 – 593 | PolarSequence analysisAdd BLAST | 25 | |
Compositional biasi | 596 – 610 | PolyampholyteSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the DSH family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00950000182903 |
HOGENOMi | CLU_012601_1_0_1 |
OMAi | TPWPLLH |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008341, DVL2 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF8, PTHR10878:SF8, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED PR01762, DISHEVELLED2 |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
I3L2N2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP
60 70 80 90 100
AGAKYFFKSM DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA
110 120 130 140 150
PPVHEPRAEL APPAPPLPPL PPERTSGIGD SRPPSFHHEN LEPETETESV
160 170 180 190 200
VSLRRERPRR RDSSEHGAGG HRTGGPSRLE RHLAGYESSS TLMTSELEST
210 220 230 240 250
SLGDSDEEDT MSRFSSSTEQ SSASRLLKRH RRRRKQRPPR LERTSSFSSV
260 270 280 290 300
TDSTMSLNII TVTLNMEKYN FLGISIVGQS NERGDGGIYI GSIMKGGAVA
310 320 330 340 350
ADGRIEPGDM LLQVNDMNFE NMSNDDAVRV LRDIVHKPGP IVLTVAKCWD
360 370 380 390 400
PSPQAYFTLP RNEPIQPIDP AAWVSHSAAL TGTFPAYPGS SSMSTITSGS
410 420 430 440 450
SLPDGCEGRG LSVHTDMASV TKAMAAPESG LEVRDRMWLK ITIPNAFLGS
460 470 480 490 500
DVVDWLYHHV EGFPERREAR KYASGLLKAG LIRHTVNKIT FSEQCYYVFG
510 520 530 540 550
DLSGGCESYL VNLSLNDNDG SSGASDQDTL APLPGATPWP LLPTFSYQYP
560 570 580 590 600
APHPYSPQPP PYHELSSYTY GGGSASSQHS EGSRSSGSTR SDGGAGRTGR
610 620 630 640 650
PEERAPESKS GSGSESEPSS RGGSLRRGGE ASGTSDGGPP PSRGSTGGAP
660 670 680 690 700
NLRAHPGLHP YGPPPGMALP YNPMMVVMMP PPPPPVPPAV QPPGAPPVRD
710 720 730
LGSVPPELTA SRQSFHMAMG NPSEFFVDVM
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO14641 | DVL2_HUMAN | Segment polarity protein dishevelle... | DVL2 | 736 | Annotation score: | ||
I3L0Z8 | I3L0Z8_HUMAN | Segment polarity protein dishevelle... | DVL2 | 300 | Annotation score: | ||
I3L2W9 | I3L2W9_HUMAN | Segment polarity protein dishevelle... | DVL2 | 363 | Annotation score: | ||
I3L0M7 | I3L0M7_HUMAN | Segment polarity protein dishevelle... | DVL2 | 291 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC120057 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000575458; ENSP00000459797; ENSG00000004975 |
UCSCi | uc010vtr.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC120057 Genomic DNA No translation available. |
3D structure databases
SMRi | I3L2N2 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | I3L2N2, 1 interactor |
Proteomic databases
MaxQBi | I3L2N2 |
PeptideAtlasi | I3L2N2 |
PRIDEi | I3L2N2 |
ProteomicsDBi | 46995 |
Protocols and materials databases
Antibodypediai | 3985, 466 antibodies |
Genome annotation databases
Ensembli | ENST00000575458; ENSP00000459797; ENSG00000004975 |
UCSCi | uc010vtr.2, human |
Organism-specific databases
HGNCi | HGNC:3086, DVL2 |
OpenTargetsi | ENSG00000004975 |
VEuPathDBi | HostDB:ENSG00000004975.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182903 |
HOGENOMi | CLU_012601_1_0_1 |
OMAi | TPWPLLH |
Miscellaneous databases
ChiTaRSi | DVL2, human |
Gene expression databases
Bgeei | ENSG00000004975, Expressed in vagina and 229 other tissues |
ExpressionAtlasi | I3L2N2, baseline and differential |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008341, DVL2 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF8, PTHR10878:SF8, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED PR01762, DISHEVELLED2 |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I3L2N2_HUMAN | |
Accessioni | I3L2N2Primary (citable) accession number: I3L2N2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | July 11, 2012 | |
Last modified: | April 7, 2021 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |