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Protein
Submitted name:

Segment polarity protein dishevelled homolog DVL-2

Gene

DVL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathwayPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Segment polarity protein dishevelled homolog DVL-2Imported
Gene namesi
Name:DVL2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000004975.11
HGNCiHGNC:3086 DVL2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000004975

PTM / Processingi

Proteomic databases

MaxQBiI3L2N2
PeptideAtlasiI3L2N2
PRIDEiI3L2N2

Expressioni

Gene expression databases

BgeeiENSG00000004975
ExpressionAtlasiI3L2N2 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiI3L2N2, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliI3L2N2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 93DIXInterPro annotationAdd BLAST83
Domaini261 – 333PDZInterPro annotationAdd BLAST73
Domaini427 – 501DEPInterPro annotationAdd BLAST75

Phylogenomic databases

eggNOGiKOG3571 Eukaryota
ENOG410Y5G4 LUCA
GeneTreeiENSGT00390000013552

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR024580 Dishevelled_C-dom
IPR008339 Dishevelled_fam
IPR003351 Dishevelled_protein_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR008341 DVL2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10878 PTHR10878, 1 hit
PTHR10878:SF8 PTHR10878:SF8, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF02377 Dishevelled, 1 hit
PF00778 DIX, 1 hit
PF12316 Dsh_C, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR01760 DISHEVELLED
PR01762 DISHEVELLED2
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

I3L2N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP
60 70 80 90 100
AGAKYFFKSM DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA
110 120 130 140 150
PPVHEPRAEL APPAPPLPPL PPERTSGIGD SRPPSFHHEN LEPETETESV
160 170 180 190 200
VSLRRERPRR RDSSEHGAGG HRTGGPSRLE RHLAGYESSS TLMTSELEST
210 220 230 240 250
SLGDSDEEDT MSRFSSSTEQ SSASRLLKRH RRRRKQRPPR LERTSSFSSV
260 270 280 290 300
TDSTMSLNII TVTLNMEKYN FLGISIVGQS NERGDGGIYI GSIMKGGAVA
310 320 330 340 350
ADGRIEPGDM LLQVNDMNFE NMSNDDAVRV LRDIVHKPGP IVLTVAKCWD
360 370 380 390 400
PSPQAYFTLP RNEPIQPIDP AAWVSHSAAL TGTFPAYPGS SSMSTITSGS
410 420 430 440 450
SLPDGCEGRG LSVHTDMASV TKAMAAPESG LEVRDRMWLK ITIPNAFLGS
460 470 480 490 500
DVVDWLYHHV EGFPERREAR KYASGLLKAG LIRHTVNKIT FSEQCYYVFG
510 520 530 540 550
DLSGGCESYL VNLSLNDNDG SSGASDQDTL APLPGATPWP LLPTFSYQYP
560 570 580 590 600
APHPYSPQPP PYHELSSYTY GGGSASSQHS EGSRSSGSTR SDGGAGRTGR
610 620 630 640 650
PEERAPESKS GSGSESEPSS RGGSLRRGGE ASGTSDGGPP PSRGSTGGAP
660 670 680 690 700
NLRAHPGLHP YGPPPGMALP YNPMMVVMMP PPPPPVPPAV QPPGAPPVRD
710 720 730
LGSVPPELTA SRQSFHMAMG NPSEFFVDVM
Length:730
Mass (Da):78,376
Last modified:July 11, 2012 - v1
Checksum:i6678D2E8EFFEC5C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120057 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000575458; ENSP00000459797; ENSG00000004975
UCSCiuc010vtr.2 human

Similar proteinsi

Entry informationi

Entry nameiI3L2N2_HUMAN
AccessioniPrimary (citable) accession number: I3L2N2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: June 20, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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