DVL2

Functionⁱ

GO - Biological processⁱ

intracellular signal transduction Source: InterPro
Wnt signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Wnt signaling pathwayPROSITE-ProRule annotation

Biological process

Wnt signaling pathwayPROSITE-ProRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Segment polarity protein dishevelled homolog DVL-2Imported
Gene namesⁱ	Name:DVL2Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000004975.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3086 DVL2

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000004975

OpenTargetsⁱ

ENSG00000004975

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	I3L2N2
PeptideAtlas More...PeptideAtlasⁱ	I3L2N2
PRIDEⁱ	I3L2N2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000004975
ExpressionAtlasⁱ	I3L2N2 baseline and differential

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	I3L2N2, 1 interactor

IntActⁱ

I3L2N2, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	I3L2N2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	11 – 93	DIXInterPro annotationAdd BLAST	83
Domainⁱ	261 – 333	PDZInterPro annotationAdd BLAST	73
Domainⁱ	427 – 501	DEPInterPro annotationAdd BLAST	75

Phylogenomic databases

eggNOGⁱ	KOG3571 Eukaryota ENOG410Y5G4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013552

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit 3.10.20.380, 1 hit
InterProⁱ	View protein in InterPro IPR000591 DEP_dom IPR024580 Dishevelled_C-dom IPR008339 Dishevelled_fam IPR003351 Dishevelled_protein_dom IPR001158 DIX IPR038207 DIX_dom_sf IPR015506 Dsh/Dvl-rel IPR008341 DVL2 IPR001478 PDZ IPR036034 PDZ_sf IPR029071 Ubiquitin-like_domsf IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR10878 PTHR10878, 1 hit PTHR10878:SF8 PTHR10878:SF8, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00610 DEP, 1 hit PF02377 Dishevelled, 1 hit PF00778 DIX, 1 hit PF12316 Dsh_C, 1 hit PF00595 PDZ, 1 hit
PRINTSⁱ	PR01760 DISHEVELLED PR01762 DISHEVELLED2
SMARTⁱ	View protein in SMART SM00021 DAX, 1 hit SM00049 DEP, 1 hit SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF50156 SSF50156, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50186 DEP, 1 hit PS50841 DIX, 1 hit PS50106 PDZ, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

I3L2N2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP 
        60         70         80         90        100
AGAKYFFKSM DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA 
       110        120        130        140        150
PPVHEPRAEL APPAPPLPPL PPERTSGIGD SRPPSFHHEN LEPETETESV 
       160        170        180        190        200
VSLRRERPRR RDSSEHGAGG HRTGGPSRLE RHLAGYESSS TLMTSELEST 
       210        220        230        240        250
SLGDSDEEDT MSRFSSSTEQ SSASRLLKRH RRRRKQRPPR LERTSSFSSV 
       260        270        280        290        300
TDSTMSLNII TVTLNMEKYN FLGISIVGQS NERGDGGIYI GSIMKGGAVA 
       310        320        330        340        350
ADGRIEPGDM LLQVNDMNFE NMSNDDAVRV LRDIVHKPGP IVLTVAKCWD 
       360        370        380        390        400
PSPQAYFTLP RNEPIQPIDP AAWVSHSAAL TGTFPAYPGS SSMSTITSGS 
       410        420        430        440        450
SLPDGCEGRG LSVHTDMASV TKAMAAPESG LEVRDRMWLK ITIPNAFLGS 
       460        470        480        490        500
DVVDWLYHHV EGFPERREAR KYASGLLKAG LIRHTVNKIT FSEQCYYVFG 
       510        520        530        540        550
DLSGGCESYL VNLSLNDNDG SSGASDQDTL APLPGATPWP LLPTFSYQYP 
       560        570        580        590        600
APHPYSPQPP PYHELSSYTY GGGSASSQHS EGSRSSGSTR SDGGAGRTGR 
       610        620        630        640        650
PEERAPESKS GSGSESEPSS RGGSLRRGGE ASGTSDGGPP PSRGSTGGAP 
       660        670        680        690        700
NLRAHPGLHP YGPPPGMALP YNPMMVVMMP PPPPPVPPAV QPPGAPPVRD 
       710        720        730
LGSVPPELTA SRQSFHMAMG NPSEFFVDVM

Length:730

Mass (Da):78,376

Last modified:July 11, 2012 - v1

Checksum:ⁱ6678D2E8EFFEC5C3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC120057 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC120057 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000575458; ENSP00000459797; ENSG00000004975
UCSC genome browser More...UCSCⁱ	uc010vtr.2 human

Protein	Similar proteins		Species	Score	Length
I3L2N2	DVL2 isoform 3		PANTR		730
UPI0002743BF4		PANPA		820

Protein	Similar proteins		Species	Score	Length
I3L2N2	Segment polarity protein dishevelled homolog DVL-2	)	HUMAN		736
DVL2 isoform 1		PANTR		736
Dishevelled segment polarity protein 2		PANPA		736
UPI0005F3C037		MANLE		832
UPI0005F44503		CERAT		822
+227

Protein	Similar proteins		Species	Score	Length
I3L2N2	Segment polarity protein dishevelled homolog DVL-2	)	HUMAN		736
DVL2 isoform 1		PANTR		736
Dishevelled segment polarity protein 2		PANPA		736
UPI0005F3C037		MANLE		832
UPI0005F44503		CERAT		822
+628

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC120057 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC120057 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	I3L2N2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	I3L2N2, 1 interactor

IntActⁱ

I3L2N2, 1 interactor

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	I3L2N2
PeptideAtlas More...PeptideAtlasⁱ	I3L2N2
PRIDEⁱ	I3L2N2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000575458; ENSP00000459797; ENSG00000004975
UCSC genome browser More...UCSCⁱ	uc010vtr.2 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000004975.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3086 DVL2
Open Targets More...OpenTargetsⁱ	ENSG00000004975
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3571 Eukaryota ENOG410Y5G4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013552

Miscellaneous databases

ChiTaRSⁱ	DVL2 human

ChiTaRSⁱ

DVL2 human

Gene expression databases

Bgeeⁱ	ENSG00000004975
ExpressionAtlasⁱ	I3L2N2 baseline and differential

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit 3.10.20.380, 1 hit
InterProⁱ	View protein in InterPro IPR000591 DEP_dom IPR024580 Dishevelled_C-dom IPR008339 Dishevelled_fam IPR003351 Dishevelled_protein_dom IPR001158 DIX IPR038207 DIX_dom_sf IPR015506 Dsh/Dvl-rel IPR008341 DVL2 IPR001478 PDZ IPR036034 PDZ_sf IPR029071 Ubiquitin-like_domsf IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR10878 PTHR10878, 1 hit PTHR10878:SF8 PTHR10878:SF8, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00610 DEP, 1 hit PF02377 Dishevelled, 1 hit PF00778 DIX, 1 hit PF12316 Dsh_C, 1 hit PF00595 PDZ, 1 hit
PRINTSⁱ	PR01760 DISHEVELLED PR01762 DISHEVELLED2
SMARTⁱ	View protein in SMART SM00021 DAX, 1 hit SM00049 DEP, 1 hit SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF50156 SSF50156, 1 hit SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50186 DEP, 1 hit PS50841 DIX, 1 hit PS50106 PDZ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	I3L2N2_HUMAN
Accessionⁱ	I3L2N2Primary (citable) accession number: I3L2N2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 11, 2012
	Last sequence update:	July 11, 2012
	Last modified:	June 20, 2018
	This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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UniProtKB - I3L2N2 (I3L2N2_HUMAN)

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Segment polarity protein dishevelled homolog DVL-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ