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Entry version 68 (02 Jun 2021)
Sequence version 1 (11 Jul 2012)
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Protein
Submitted name:

Centrosomal protein of 131 kDa

Gene

CEP131

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Centrosomal protein of 131 kDaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP131Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29511, CEP131

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000141577.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000141577

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
I3L2J8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
I3L2J8

PeptideAtlas

More...
PeptideAtlasi
I3L2J8

PRoteomics IDEntifications database

More...
PRIDEi
I3L2J8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
46969

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141577, Expressed in sural nerve and 120 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
I3L2J8, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 155DisorderedSequence analysisAdd BLAST155
Regioni220 – 258DisorderedSequence analysisAdd BLAST39
Regioni301 – 429DisorderedSequence analysisAdd BLAST129
Regioni1014 – 1047DisorderedSequence analysisAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili573 – 593Sequence analysisAdd BLAST21
Coiled coili606 – 626Sequence analysisAdd BLAST21
Coiled coili634 – 690Sequence analysisAdd BLAST57
Coiled coili738 – 802Sequence analysisAdd BLAST65
Coiled coili812 – 832Sequence analysisAdd BLAST21
Coiled coili868 – 928Sequence analysisAdd BLAST61
Coiled coili932 – 963Sequence analysisAdd BLAST32
Coiled coili965 – 992Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi65 – 91Polar residuesSequence analysisAdd BLAST27
Compositional biasi227 – 250Polar residuesSequence analysisAdd BLAST24
Compositional biasi317 – 337Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi380 – 394Polar residuesSequence analysisAdd BLAST15
Compositional biasi414 – 428Polar residuesSequence analysisAdd BLAST15
Compositional biasi1014 – 1041Basic and acidic residuesSequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001758

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSATQVN

Database of Orthologous Groups

More...
OrthoDBi
918776at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030465, CEP131

The PANTHER Classification System

More...
PANTHERi
PTHR31540, PTHR31540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

I3L2J8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGTRAIGSV PERSPAGVDL SLTGLPPPVS RRPGSAATTK PIVRSVSVVT
60 70 80 90 100
GSEQKRKVLE ATGPGGSQAI NNLRRSNSTT QVSQPRSGSP RPTEPTDFLM
110 120 130 140 150
LFEGSPSGKK RPASLSTAPS EKGATWNVLD DQPRGFTLPS NARSSSALDS
160 170 180 190 200
PAGPRRKECT VALAPNFTAN NRSNKGAVGN CVTTMVHNRY TPSERAPPLK
210 220 230 240 250
SSNQTAPSLN NIIKAATCEG SESSGFGKLP KNVSSATHSA RNNTGGSTGL
260 270 280 290 300
PRRKEVTEEE AERFIHQVNQ ATVTIQRWYR HQVQRRGAGA ARLEHLLQAK
310 320 330 340 350
REEQRQRSGE GTLLDLHQQK EAARRKAREE KARQARRAAI QELQQKRALR
360 370 380 390 400
AQKASTAERG PPENPRETRV PGMRQPAQEL SPTPGGTAHQ ALKANNTGGG
410 420 430 440 450
LPAAGPGDRC LPTSDSSPEP QQPPEDRTQD VLAQDAAGDN LEMMAPSRGS
460 470 480 490 500
AKSRGPLEEL LHTLQLLEKE PDVLPRPRTH HRGRYAWASE VTTEDDASSL
510 520 530 540 550
TADNLEKFGK LSAFPEPPED GTLLSEAKLQ SIMSFLDEME KSGQDQLDSQ
560 570 580 590 600
QEGWVPEAGP GPLELGSEVS TSVMRLKLEV EEKKQAMLLL QRALAQQRDL
610 620 630 640 650
TARRVKETEK ALSRQLQRQR EHYEATIQRH LAFIDQLIED KKVLSEKCEA
660 670 680 690 700
VVAELKQEDQ RCTERVAQAQ AQHELEIKKL KELMSATEKA RREKWISEKT
710 720 730 740 750
KKIKEVTVRG LEPEIQKLIA RHKQEVRRLK SLHEAELLQS DERASQRCLR
760 770 780 790 800
QAEELREQLE REKEALGQQE RERARQRQRA ELEELRQQLE ESSSALTRAL
810 820 830 840 850
RAEFEKGREE QERRHQMELN TLKQQLELER QAWEAGRTRK EEAWLLNREQ
860 870 880 890 900
ELREEIRKGR DKEIELVIHR LEADMALAKE ESEKAAESRI KRLRDKYEAE
910 920 930 940 950
LSELEQSERK LQERCSELKG QLGEAEGENL RLQGLVRQKE RALEDAQAVN
960 970 980 990 1000
EQLSSERSNL AQVIRQEFED RLAASEEETR QAKAELATLQ ARQQLELEEV
1010 1020 1030 1040
HRRVKTALAR KEEAVSSLRT QHEAAVKRAD HLEELLEQHR RPTPSTK
Length:1,047
Mass (Da):117,698
Last modified:July 11, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC59EEC60480BE9C2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UPN4CP131_HUMAN
Centrosomal protein of 131 kDa
CEP131 AZI1, KIAA1118
1,083Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4M5I3L4M5_HUMAN
Centrosomal protein of 131 kDa
CEP131
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2X7I3L2X7_HUMAN
Centrosomal protein of 131 kDa
CEP131
524Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L316I3L316_HUMAN
Centrosomal protein of 131 kDa
CEP131
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC027601 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001306158.1, NM_001319229.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000575907; ENSP00000459733; ENSG00000141577

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22994

UCSC genome browser

More...
UCSCi
uc010wum.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027601 Genomic DNA No translation available.
RefSeqiNP_001306158.1, NM_001319229.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiI3L2J8
MaxQBiI3L2J8
PeptideAtlasiI3L2J8
PRIDEiI3L2J8
ProteomicsDBi46969

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
19799, 110 antibodies

The DNASU plasmid repository

More...
DNASUi
22994

Genome annotation databases

EnsembliENST00000575907; ENSP00000459733; ENSG00000141577
GeneIDi22994
UCSCiuc010wum.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22994
HGNCiHGNC:29511, CEP131
OpenTargetsiENSG00000141577
VEuPathDBiHostDB:ENSG00000141577.13

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000001758
OMAiNSATQVN
OrthoDBi918776at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22994, 346 hits in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CEP131, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22994

Gene expression databases

BgeeiENSG00000141577, Expressed in sural nerve and 120 other tissues
ExpressionAtlasiI3L2J8, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR030465, CEP131
PANTHERiPTHR31540, PTHR31540, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3L2J8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3L2J8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: June 2, 2021
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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