UniProtKB - I3L2J0 (I3L2J0_HUMAN)
Protein
Submitted name:
Protein capicua homolog
Gene
CIC
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 1109 – 1177 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA binding Source: UniProtKB-UniRule
GO - Biological processi
- brain development Source: Ensembl
- learning Source: Ensembl
- lung alveolus development Source: Ensembl
- memory Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- social behavior Source: Ensembl
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Protein capicua homologImported |
Gene namesi | Name:CICImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14214, CIC |
VEuPathDBi | HostDB:ENSG00000079432.7 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-UniRule
Other locations
- protein-containing complex Source: Ensembl
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationPTM / Processingi
Proteomic databases
EPDi | I3L2J0 |
MaxQBi | I3L2J0 |
PeptideAtlasi | I3L2J0 |
PRIDEi | I3L2J0 |
ProteomicsDBi | 46961 |
Expressioni
Gene expression databases
Bgeei | ENSG00000079432, Expressed in right testis and 231 other tissues |
ExpressionAtlasi | I3L2J0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1109 – 1177 | HMG boxInterPro annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 197 | DisorderedSequence analysisAdd BLAST | 197 | |
Regioni | 300 – 325 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 342 – 483 | DisorderedSequence analysisAdd BLAST | 142 | |
Regioni | 531 – 579 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 608 – 641 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 658 – 767 | DisorderedSequence analysisAdd BLAST | 110 | |
Regioni | 812 – 842 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 955 – 1110 | DisorderedSequence analysisAdd BLAST | 156 | |
Regioni | 1179 – 1220 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 1235 – 1274 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 1290 – 1347 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 1379 – 1539 | DisorderedSequence analysisAdd BLAST | 161 | |
Regioni | 1595 – 1628 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 1799 – 1818 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 2038 – 2062 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 2098 – 2253 | DisorderedSequence analysisAdd BLAST | 156 | |
Regioni | 2266 – 2338 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 2427 – 2514 | DisorderedSequence analysisAdd BLAST | 88 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 155 – 169 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 308 – 322 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 410 – 432 | Pro-richSequence analysisAdd BLAST | 23 | |
Compositional biasi | 442 – 461 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 608 – 623 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 675 – 690 | Pro-richSequence analysisAdd BLAST | 16 | |
Compositional biasi | 694 – 709 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 746 – 762 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 959 – 984 | PolarSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1008 – 1022 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1043 – 1061 | PolyampholyteSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1083 – 1110 | PolyampholyteSequence analysisAdd BLAST | 28 | |
Compositional biasi | 1379 – 1398 | PolyampholyteSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1417 – 1431 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1439 – 1476 | PolarSequence analysisAdd BLAST | 38 | |
Compositional biasi | 1799 – 1814 | Pro-richSequence analysisAdd BLAST | 16 | |
Compositional biasi | 2040 – 2056 | Pro-richSequence analysisAdd BLAST | 17 | |
Compositional biasi | 2130 – 2162 | Pro-richSequence analysisAdd BLAST | 33 | |
Compositional biasi | 2171 – 2186 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 2193 – 2207 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2222 – 2236 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2298 – 2325 | PolyampholyteSequence analysisAdd BLAST | 28 | |
Compositional biasi | 2435 – 2464 | Pro-richSequence analysisAdd BLAST | 30 | |
Compositional biasi | 2477 – 2514 | Pro-richSequence analysisAdd BLAST | 38 |
Phylogenomic databases
GeneTreei | ENSGT00940000159960 |
HOGENOMi | CLU_000921_0_0_1 |
OMAi | MKKACAG |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR032147, DUF4819 IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF16090, DUF4819, 1 hit PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
I3L2J0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKPMKKACTG LSGPGSGSKS PPATRAKALR RRGAGEGDKP EEEDDEAQQP
60 70 80 90 100
QPQSGPEEAE EGEEEEAERG PGAEGPPLEL HPGDPAPGPA EDPKGDGEAG
110 120 130 140 150
RWEPSLSRKT ATFKSRAPKK KYVEEHGAGS SGVAGAPEER VRTPEEASGL
160 170 180 190 200
GVPPRPPTST RSSSTDTASE HSADLEDEPA EACGPGPWPP GSTSGSYDLR
210 220 230 240 250
QLRSQRVLAR RGDGLFLPAV VRQVRRSQDL GVQFPGDRAL TFYEGVPGAG
260 270 280 290 300
VDVVLDATPP PGALVVGTAV CTCVEPGVAA YREGVVVEVA TKPAAYKVRL
310 320 330 340 350
SPGPSSQPGL PGSLPQPPQP LHREPEEAVW VARSSLRLLR PPWEPETMLR
360 370 380 390 400
KPPTGPEEEQ AEPGATLPPC PAALDPKQPE DAEVSKISFG GNLGTHCEEG
410 420 430 440 450
EEKHPPALGT PALLPLPPPQ LLSPPPKSPA FVGPGRPGEQ PSPCQEGSQG
460 470 480 490 500
GSRSSSVASL EKGTAPAARA RTPLTAAQQK YKKGDVVCTP SGIRKKFNGK
510 520 530 540 550
QWRRLCSRDG CMKESQRRGY CSRHLSMRTK EMEGLADSGP GGAGRPAAVA
560 570 580 590 600
AREGSTEFDW GDETSRDSEA SSVAARGDSR PRLVAPADLS RFEFDECEAA
610 620 630 640 650
VMLVSLGSSR SGTPSFSPVS TQSPFSPAPS PSPSPLFGFR PANFSPINAS
660 670 680 690 700
PVIQRTAVRS RHLSASTPKA GVLTPPDLGP HPPPPAPRER HSSGILPTFQ
710 720 730 740 750
TNLTFTVPIS PGRRKTELLP HPGALGAPGA GGGGAAPDFP KSDSLDSGVD
760 770 780 790 800
SVSHTPTPST PAGFRAVSPA VPFSRSRQPS PLLLLPPPAG LTSDPGPSVR
810 820 830 840 850
RVPAVQRDSP VIVRNPDVPL PSKFPGEVGT AGEVRAGGPG RGCRETPVPP
860 870 880 890 900
GVASGKPGLP PPLPAPVPIT VPPAAPTAVA QPMPAFGLAS SPFQPVAFHP
910 920 930 940 950
SPAALLPVLV PSSYTSHPAP KKEVIMGRPG TVWTNVEPRS VAVFPWHSLV
960 970 980 990 1000
PFLAPSQPDP SVQPSEAQQP ASHPVASNQS KEPAESAAVA HERPPGGTGS
1010 1020 1030 1040 1050
ADPERPPGAT CPESPGPGPP HPLGVVESGK GPPPTTEEEA SGPPGEPRLD
1060 1070 1080 1090 1100
SETESDHDDA FLSIMSPEIQ LPLPPGKRRT QSLSALPKER DSSSEKDGRS
1110 1120 1130 1140 1150
PNKREKDHIR RPMNAFMIFS KRHRALVHQR HPNQDNRTVS KILGEWWYAL
1160 1170 1180 1190 1200
GPKEKQKYHD LAFQVKEAHF KAHPDWKWCN KDRKKSSSEA KPTSLGLAGG
1210 1220 1230 1240 1250
HKETRERSMS ETGTAAAPGV SSELLSVAAQ TLLSSDTKAP GSSSCGAERL
1260 1270 1280 1290 1300
HTVGGPGSAR PRAFSHSGVH SLDGGEVDSQ ALQELTQMVS GPASYSGPKP
1310 1320 1330 1340 1350
STQYGAPGPF AAPGEGGALA ATGRPPLLPT RASRSQRAAS EDMTSDEERM
1360 1370 1380 1390 1400
VICEEEGDDD VIADDGFGTT DIDLKCKERV TDSESGDSSG EDPEGNKGFG
1410 1420 1430 1440 1450
RKVFSPVIRS SFTHCRPPLD PEPPGPPDPP VAFGKGYGSA PSSSASSPAS
1460 1470 1480 1490 1500
SSASAATSFS LGSGTFKAQE SGQGSTAGPL RPPPPGAGGP ATPSKATRFL
1510 1520 1530 1540 1550
PMDPATFRRK RPESVGGLEP PGPSVIAAPP SGGGNILQTL VLPPNKEEQE
1560 1570 1580 1590 1600
GGGARVPSAP APSLAYGAPA APLSRPAATM VTNVVRPVSS TPVPIASKPF
1610 1620 1630 1640 1650
PTSGRAEASP NDTAGARTEM GTGSRVPGGS PLGVSLVYSD KKSAAATSPA
1660 1670 1680 1690 1700
PHLVAGPLLG TVGKAPATVT NLLVGTPGYG APAPPAVQFI AQGAPGGGTT
1710 1720 1730 1740 1750
AGSGAGAGSG PNGPVPLGIL QPGALGKAGG ITQVQYILPT LPQQLQVAPA
1760 1770 1780 1790 1800
PAPAPGTKAA APSGPAPTTS IRFTLPPGTS TNGKVLAATA PTPGIPILQS
1810 1820 1830 1840 1850
VPSAPPPKAQ SVSPVQAPPP GGSAQLLPGK VLVPLAAPSM SVRGGGAGQP
1860 1870 1880 1890 1900
LPLVSPPFSV PVQNGAQPPS KIIQLTPVPV STPSGLVPPL SPATLPGPTS
1910 1920 1930 1940 1950
QPQKVLLPSS TRITYVQSAG GHALPLGTSP ASSQAGTVTS YGPTSSVALG
1960 1970 1980 1990 2000
FTSLGPSGPA FVQPLLSGQA PLLAPGQVGV SPVPSPQLPP ACAAPGGPVI
2010 2020 2030 2040 2050
TAFYSGSPAP TSSAPLAQPS QAPPSLVYTV ATSTTPPAAT ILPKGPPAPA
2060 2070 2080 2090 2100
TATPAPTSPF PSATGSMTYS LVAPKAQRPS PKAPQKVKAA IASIPVGSFE
2110 2120 2130 2140 2150
AGASGRPGPA PRQPLEPGPV REPTAPESEL EGQPTPPAPP PLPETWTPTA
2160 2170 2180 2190 2200
RSSPPLPPPA EERTSAKGPE TMASKFPSSS SDWRVPGQGL ENRGEPPTPP
2210 2220 2230 2240 2250
SPAPAPAVAP GGSSESSSGR AAGDTPERKE AAGTGKKVKV RPPPLKKTFD
2260 2270 2280 2290 2300
SVDKVLSEVD FEERFAELPE FRPEEVLPSP TLQSLATSPR AILGSYRKKR
2310 2320 2330 2340 2350
KNSTDLDSAP EDPTSPKRKM RRRSSCSSEP NTPKSAKCEG DIFTFDRTGT
2360 2370 2380 2390 2400
EAEDVLGELE YDKVPYSSLR RTLDQRRALV MQLFQDHGFF PSAQATAAFQ
2410 2420 2430 2440 2450
ARYADIFPSK VCLQLKIREV RQKIMQAATP TEQPPGAEAP LPVPPPTGTA
2460 2470 2480 2490 2500
AAPAPTPSPA GGPDPTSPSS DSGTAQAAPP LPPPPESGPG QPGWEGAPQP
2510
SPPPPGPSTA ATGR
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ96RK0 | CIC_HUMAN | Protein capicua homolog | CIC KIAA0306 | 1,608 | Annotation score: | ||
A0A0A0MQR4 | A0A0A0MQR4_HUMAN | Protein capicua homolog | CIC | 1,606 | Annotation score: | ||
I3L1Q4 | I3L1Q4_HUMAN | Protein capicua homolog | CIC | 320 | Annotation score: | ||
I3L373 | I3L373_HUMAN | Protein capicua homolog | CIC | 144 | Annotation score: | ||
I3L135 | I3L135_HUMAN | Protein capicua homolog | CIC | 309 | Annotation score: | ||
I3L2I4 | I3L2I4_HUMAN | Protein capicua homolog | CIC | 144 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006486 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000572681; ENSP00000459719; ENSG00000079432 |
UCSCi | uc021uvd.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006486 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | I3L2J0, 2 interactors |
Proteomic databases
EPDi | I3L2J0 |
MaxQBi | I3L2J0 |
PeptideAtlasi | I3L2J0 |
PRIDEi | I3L2J0 |
ProteomicsDBi | 46961 |
Protocols and materials databases
Antibodypediai | 17427, 255 antibodies |
Genome annotation databases
Ensembli | ENST00000572681; ENSP00000459719; ENSG00000079432 |
UCSCi | uc021uvd.2, human |
Organism-specific databases
HGNCi | HGNC:14214, CIC |
OpenTargetsi | ENSG00000079432 |
VEuPathDBi | HostDB:ENSG00000079432.7 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159960 |
HOGENOMi | CLU_000921_0_0_1 |
OMAi | MKKACAG |
Miscellaneous databases
ChiTaRSi | CIC, human |
Gene expression databases
Bgeei | ENSG00000079432, Expressed in right testis and 231 other tissues |
ExpressionAtlasi | I3L2J0, baseline and differential |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR032147, DUF4819 IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF16090, DUF4819, 1 hit PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I3L2J0_HUMAN | |
Accessioni | I3L2J0Primary (citable) accession number: I3L2J0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | July 11, 2012 | |
Last modified: | February 10, 2021 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |