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Entry version 60 (31 Jul 2019)
Sequence version 1 (11 Jul 2012)
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Protein
Submitted name:

Protein capicua homolog

Gene

CIC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1109 – 1177HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein capicua homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CICImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14214 CIC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000079432

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
I3L2J0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
I3L2J0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
I3L2J0

PeptideAtlas

More...
PeptideAtlasi
I3L2J0

PRoteomics IDEntifications database

More...
PRIDEi
I3L2J0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
46961

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000079432 Expressed in 219 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
I3L2J0 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
I3L2J0, 2 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1109 – 1177HMG boxInterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 197DisorderedSequence analysisAdd BLAST197
Regioni300 – 325DisorderedSequence analysisAdd BLAST26
Regioni342 – 483DisorderedSequence analysisAdd BLAST142
Regioni531 – 579DisorderedSequence analysisAdd BLAST49
Regioni608 – 641DisorderedSequence analysisAdd BLAST34
Regioni658 – 767DisorderedSequence analysisAdd BLAST110
Regioni812 – 842DisorderedSequence analysisAdd BLAST31
Regioni955 – 1110DisorderedSequence analysisAdd BLAST156
Regioni1179 – 1220DisorderedSequence analysisAdd BLAST42
Regioni1235 – 1274DisorderedSequence analysisAdd BLAST40
Regioni1290 – 1347DisorderedSequence analysisAdd BLAST58
Regioni1379 – 1539DisorderedSequence analysisAdd BLAST161
Regioni1595 – 1628DisorderedSequence analysisAdd BLAST34
Regioni1799 – 1818DisorderedSequence analysisAdd BLAST20
Regioni2038 – 2062DisorderedSequence analysisAdd BLAST25
Regioni2098 – 2253DisorderedSequence analysisAdd BLAST156
Regioni2266 – 2338DisorderedSequence analysisAdd BLAST73
Regioni2427 – 2514DisorderedSequence analysisAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi155 – 169PolarSequence analysisAdd BLAST15
Compositional biasi308 – 322Pro-richSequence analysisAdd BLAST15
Compositional biasi410 – 432Pro-richSequence analysisAdd BLAST23
Compositional biasi442 – 461PolarSequence analysisAdd BLAST20
Compositional biasi608 – 623PolarSequence analysisAdd BLAST16
Compositional biasi675 – 690Pro-richSequence analysisAdd BLAST16
Compositional biasi694 – 709PolarSequence analysisAdd BLAST16
Compositional biasi746 – 762PolarSequence analysisAdd BLAST17
Compositional biasi959 – 984PolarSequence analysisAdd BLAST26
Compositional biasi1008 – 1022Pro-richSequence analysisAdd BLAST15
Compositional biasi1043 – 1061PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1083 – 1110PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1379 – 1398PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1417 – 1431Pro-richSequence analysisAdd BLAST15
Compositional biasi1439 – 1476PolarSequence analysisAdd BLAST38
Compositional biasi1799 – 1814Pro-richSequence analysisAdd BLAST16
Compositional biasi2040 – 2056Pro-richSequence analysisAdd BLAST17
Compositional biasi2130 – 2162Pro-richSequence analysisAdd BLAST33
Compositional biasi2171 – 2186PolarSequence analysisAdd BLAST16
Compositional biasi2193 – 2207Pro-richSequence analysisAdd BLAST15
Compositional biasi2222 – 2236PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2298 – 2325PolyampholyteSequence analysisAdd BLAST28
Compositional biasi2435 – 2464Pro-richSequence analysisAdd BLAST30
Compositional biasi2477 – 2514Pro-richSequence analysisAdd BLAST38

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITBG Eukaryota
ENOG4111S7E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159960

Identification of Orthologs from Complete Genome Data

More...
OMAi
PPETWTP

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032147 DUF4819
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16090 DUF4819, 1 hit
PF00505 HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00398 HMG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095 SSF47095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

I3L2J0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPMKKACTG LSGPGSGSKS PPATRAKALR RRGAGEGDKP EEEDDEAQQP
60 70 80 90 100
QPQSGPEEAE EGEEEEAERG PGAEGPPLEL HPGDPAPGPA EDPKGDGEAG
110 120 130 140 150
RWEPSLSRKT ATFKSRAPKK KYVEEHGAGS SGVAGAPEER VRTPEEASGL
160 170 180 190 200
GVPPRPPTST RSSSTDTASE HSADLEDEPA EACGPGPWPP GSTSGSYDLR
210 220 230 240 250
QLRSQRVLAR RGDGLFLPAV VRQVRRSQDL GVQFPGDRAL TFYEGVPGAG
260 270 280 290 300
VDVVLDATPP PGALVVGTAV CTCVEPGVAA YREGVVVEVA TKPAAYKVRL
310 320 330 340 350
SPGPSSQPGL PGSLPQPPQP LHREPEEAVW VARSSLRLLR PPWEPETMLR
360 370 380 390 400
KPPTGPEEEQ AEPGATLPPC PAALDPKQPE DAEVSKISFG GNLGTHCEEG
410 420 430 440 450
EEKHPPALGT PALLPLPPPQ LLSPPPKSPA FVGPGRPGEQ PSPCQEGSQG
460 470 480 490 500
GSRSSSVASL EKGTAPAARA RTPLTAAQQK YKKGDVVCTP SGIRKKFNGK
510 520 530 540 550
QWRRLCSRDG CMKESQRRGY CSRHLSMRTK EMEGLADSGP GGAGRPAAVA
560 570 580 590 600
AREGSTEFDW GDETSRDSEA SSVAARGDSR PRLVAPADLS RFEFDECEAA
610 620 630 640 650
VMLVSLGSSR SGTPSFSPVS TQSPFSPAPS PSPSPLFGFR PANFSPINAS
660 670 680 690 700
PVIQRTAVRS RHLSASTPKA GVLTPPDLGP HPPPPAPRER HSSGILPTFQ
710 720 730 740 750
TNLTFTVPIS PGRRKTELLP HPGALGAPGA GGGGAAPDFP KSDSLDSGVD
760 770 780 790 800
SVSHTPTPST PAGFRAVSPA VPFSRSRQPS PLLLLPPPAG LTSDPGPSVR
810 820 830 840 850
RVPAVQRDSP VIVRNPDVPL PSKFPGEVGT AGEVRAGGPG RGCRETPVPP
860 870 880 890 900
GVASGKPGLP PPLPAPVPIT VPPAAPTAVA QPMPAFGLAS SPFQPVAFHP
910 920 930 940 950
SPAALLPVLV PSSYTSHPAP KKEVIMGRPG TVWTNVEPRS VAVFPWHSLV
960 970 980 990 1000
PFLAPSQPDP SVQPSEAQQP ASHPVASNQS KEPAESAAVA HERPPGGTGS
1010 1020 1030 1040 1050
ADPERPPGAT CPESPGPGPP HPLGVVESGK GPPPTTEEEA SGPPGEPRLD
1060 1070 1080 1090 1100
SETESDHDDA FLSIMSPEIQ LPLPPGKRRT QSLSALPKER DSSSEKDGRS
1110 1120 1130 1140 1150
PNKREKDHIR RPMNAFMIFS KRHRALVHQR HPNQDNRTVS KILGEWWYAL
1160 1170 1180 1190 1200
GPKEKQKYHD LAFQVKEAHF KAHPDWKWCN KDRKKSSSEA KPTSLGLAGG
1210 1220 1230 1240 1250
HKETRERSMS ETGTAAAPGV SSELLSVAAQ TLLSSDTKAP GSSSCGAERL
1260 1270 1280 1290 1300
HTVGGPGSAR PRAFSHSGVH SLDGGEVDSQ ALQELTQMVS GPASYSGPKP
1310 1320 1330 1340 1350
STQYGAPGPF AAPGEGGALA ATGRPPLLPT RASRSQRAAS EDMTSDEERM
1360 1370 1380 1390 1400
VICEEEGDDD VIADDGFGTT DIDLKCKERV TDSESGDSSG EDPEGNKGFG
1410 1420 1430 1440 1450
RKVFSPVIRS SFTHCRPPLD PEPPGPPDPP VAFGKGYGSA PSSSASSPAS
1460 1470 1480 1490 1500
SSASAATSFS LGSGTFKAQE SGQGSTAGPL RPPPPGAGGP ATPSKATRFL
1510 1520 1530 1540 1550
PMDPATFRRK RPESVGGLEP PGPSVIAAPP SGGGNILQTL VLPPNKEEQE
1560 1570 1580 1590 1600
GGGARVPSAP APSLAYGAPA APLSRPAATM VTNVVRPVSS TPVPIASKPF
1610 1620 1630 1640 1650
PTSGRAEASP NDTAGARTEM GTGSRVPGGS PLGVSLVYSD KKSAAATSPA
1660 1670 1680 1690 1700
PHLVAGPLLG TVGKAPATVT NLLVGTPGYG APAPPAVQFI AQGAPGGGTT
1710 1720 1730 1740 1750
AGSGAGAGSG PNGPVPLGIL QPGALGKAGG ITQVQYILPT LPQQLQVAPA
1760 1770 1780 1790 1800
PAPAPGTKAA APSGPAPTTS IRFTLPPGTS TNGKVLAATA PTPGIPILQS
1810 1820 1830 1840 1850
VPSAPPPKAQ SVSPVQAPPP GGSAQLLPGK VLVPLAAPSM SVRGGGAGQP
1860 1870 1880 1890 1900
LPLVSPPFSV PVQNGAQPPS KIIQLTPVPV STPSGLVPPL SPATLPGPTS
1910 1920 1930 1940 1950
QPQKVLLPSS TRITYVQSAG GHALPLGTSP ASSQAGTVTS YGPTSSVALG
1960 1970 1980 1990 2000
FTSLGPSGPA FVQPLLSGQA PLLAPGQVGV SPVPSPQLPP ACAAPGGPVI
2010 2020 2030 2040 2050
TAFYSGSPAP TSSAPLAQPS QAPPSLVYTV ATSTTPPAAT ILPKGPPAPA
2060 2070 2080 2090 2100
TATPAPTSPF PSATGSMTYS LVAPKAQRPS PKAPQKVKAA IASIPVGSFE
2110 2120 2130 2140 2150
AGASGRPGPA PRQPLEPGPV REPTAPESEL EGQPTPPAPP PLPETWTPTA
2160 2170 2180 2190 2200
RSSPPLPPPA EERTSAKGPE TMASKFPSSS SDWRVPGQGL ENRGEPPTPP
2210 2220 2230 2240 2250
SPAPAPAVAP GGSSESSSGR AAGDTPERKE AAGTGKKVKV RPPPLKKTFD
2260 2270 2280 2290 2300
SVDKVLSEVD FEERFAELPE FRPEEVLPSP TLQSLATSPR AILGSYRKKR
2310 2320 2330 2340 2350
KNSTDLDSAP EDPTSPKRKM RRRSSCSSEP NTPKSAKCEG DIFTFDRTGT
2360 2370 2380 2390 2400
EAEDVLGELE YDKVPYSSLR RTLDQRRALV MQLFQDHGFF PSAQATAAFQ
2410 2420 2430 2440 2450
ARYADIFPSK VCLQLKIREV RQKIMQAATP TEQPPGAEAP LPVPPPTGTA
2460 2470 2480 2490 2500
AAPAPTPSPA GGPDPTSPSS DSGTAQAAPP LPPPPESGPG QPGWEGAPQP
2510
SPPPPGPSTA ATGR
Length:2,514
Mass (Da):257,749
Last modified:July 11, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29DA35E5B34B6D00
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96RK0CIC_HUMAN
Protein capicua homolog
CIC KIAA0306
1,608Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQR4A0A0A0MQR4_HUMAN
Protein capicua homolog
CIC
1,606Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1Q4I3L1Q4_HUMAN
Protein capicua homolog
CIC
320Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L373I3L373_HUMAN
Protein capicua homolog
CIC
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L135I3L135_HUMAN
Protein capicua homolog
CIC
309Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2I4I3L2I4_HUMAN
Protein capicua homolog
CIC
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC006486 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000572681; ENSP00000459719; ENSG00000079432

UCSC genome browser

More...
UCSCi
uc021uvd.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006486 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiI3L2J0, 2 interactors

Proteomic databases

EPDiI3L2J0
jPOSTiI3L2J0
MaxQBiI3L2J0
PeptideAtlasiI3L2J0
PRIDEiI3L2J0
ProteomicsDBi46961

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000572681; ENSP00000459719; ENSG00000079432
UCSCiuc021uvd.2 human

Organism-specific databases

HGNCiHGNC:14214 CIC
OpenTargetsiENSG00000079432

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITBG Eukaryota
ENOG4111S7E LUCA
GeneTreeiENSGT00940000159960
OMAiPPETWTP

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CIC human

Gene expression databases

BgeeiENSG00000079432 Expressed in 219 organ(s), highest expression level in right testis
ExpressionAtlasiI3L2J0 baseline and differential

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR032147 DUF4819
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF16090 DUF4819, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3L2J0_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3L2J0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: July 31, 2019
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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