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UniProtKB - I3L2J0 (I3L2J0_HUMAN)

Entry version 60 (31 Jul 2019)
Sequence version 1 (11 Jul 2012)
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Protein
Submitted name:

Protein capicua homolog

Gene

CIC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1109 – 1177HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein capicua homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CICImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14214 CIC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000079432

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		I3L2J0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		I3L2J0

MaxQB - The MaxQuant DataBase

More...MaxQBi		I3L2J0

PeptideAtlas

More...PeptideAtlasi		I3L2J0

PRoteomics IDEntifications database

More...PRIDEi		I3L2J0

ProteomicsDB human proteome resource

More...ProteomicsDBi		46961

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000079432 Expressed in 219 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		I3L2J0 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		I3L2J0, 2 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1109 – 1177HMG boxInterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 197DisorderedSequence analysisAdd BLAST197
Regioni300 – 325DisorderedSequence analysisAdd BLAST26
Regioni342 – 483DisorderedSequence analysisAdd BLAST142
Regioni531 – 579DisorderedSequence analysisAdd BLAST49
Regioni608 – 641DisorderedSequence analysisAdd BLAST34
Regioni658 – 767DisorderedSequence analysisAdd BLAST110
Regioni812 – 842DisorderedSequence analysisAdd BLAST31
Regioni955 – 1110DisorderedSequence analysisAdd BLAST156
Regioni1179 – 1220DisorderedSequence analysisAdd BLAST42
Regioni1235 – 1274DisorderedSequence analysisAdd BLAST40
Regioni1290 – 1347DisorderedSequence analysisAdd BLAST58
Regioni1379 – 1539DisorderedSequence analysisAdd BLAST161
Regioni1595 – 1628DisorderedSequence analysisAdd BLAST34
Regioni1799 – 1818DisorderedSequence analysisAdd BLAST20
Regioni2038 – 2062DisorderedSequence analysisAdd BLAST25
Regioni2098 – 2253DisorderedSequence analysisAdd BLAST156
Regioni2266 – 2338DisorderedSequence analysisAdd BLAST73
Regioni2427 – 2514DisorderedSequence analysisAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi155 – 169PolarSequence analysisAdd BLAST15
Compositional biasi308 – 322Pro-richSequence analysisAdd BLAST15
Compositional biasi410 – 432Pro-richSequence analysisAdd BLAST23
Compositional biasi442 – 461PolarSequence analysisAdd BLAST20
Compositional biasi608 – 623PolarSequence analysisAdd BLAST16
Compositional biasi675 – 690Pro-richSequence analysisAdd BLAST16
Compositional biasi694 – 709PolarSequence analysisAdd BLAST16
Compositional biasi746 – 762PolarSequence analysisAdd BLAST17
Compositional biasi959 – 984PolarSequence analysisAdd BLAST26
Compositional biasi1008 – 1022Pro-richSequence analysisAdd BLAST15
Compositional biasi1043 – 1061PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1083 – 1110PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1379 – 1398PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1417 – 1431Pro-richSequence analysisAdd BLAST15
Compositional biasi1439 – 1476PolarSequence analysisAdd BLAST38
Compositional biasi1799 – 1814Pro-richSequence analysisAdd BLAST16
Compositional biasi2040 – 2056Pro-richSequence analysisAdd BLAST17
Compositional biasi2130 – 2162Pro-richSequence analysisAdd BLAST33
Compositional biasi2171 – 2186PolarSequence analysisAdd BLAST16
Compositional biasi2193 – 2207Pro-richSequence analysisAdd BLAST15
Compositional biasi2222 – 2236PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2298 – 2325PolyampholyteSequence analysisAdd BLAST28
Compositional biasi2435 – 2464Pro-richSequence analysisAdd BLAST30
Compositional biasi2477 – 2514Pro-richSequence analysisAdd BLAST38

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410ITBG Eukaryota
ENOG4111S7E LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159960

Identification of Orthologs from Complete Genome Data

More...OMAi		PPETWTP

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032147 DUF4819
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16090 DUF4819, 1 hit
PF00505 HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00398 HMG, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47095 SSF47095, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

I3L2J0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPMKKACTG LSGPGSGSKS PPATRAKALR RRGAGEGDKP EEEDDEAQQP 
        60         70         80         90        100
QPQSGPEEAE EGEEEEAERG PGAEGPPLEL HPGDPAPGPA EDPKGDGEAG 
       110        120        130        140        150
RWEPSLSRKT ATFKSRAPKK KYVEEHGAGS SGVAGAPEER VRTPEEASGL 
       160        170        180        190        200
GVPPRPPTST RSSSTDTASE HSADLEDEPA EACGPGPWPP GSTSGSYDLR 
       210        220        230        240        250
QLRSQRVLAR RGDGLFLPAV VRQVRRSQDL GVQFPGDRAL TFYEGVPGAG 
       260        270        280        290        300
VDVVLDATPP PGALVVGTAV CTCVEPGVAA YREGVVVEVA TKPAAYKVRL 
       310        320        330        340        350
SPGPSSQPGL PGSLPQPPQP LHREPEEAVW VARSSLRLLR PPWEPETMLR 
       360        370        380        390        400
KPPTGPEEEQ AEPGATLPPC PAALDPKQPE DAEVSKISFG GNLGTHCEEG 
       410        420        430        440        450
EEKHPPALGT PALLPLPPPQ LLSPPPKSPA FVGPGRPGEQ PSPCQEGSQG 
       460        470        480        490        500
GSRSSSVASL EKGTAPAARA RTPLTAAQQK YKKGDVVCTP SGIRKKFNGK 
       510        520        530        540        550
QWRRLCSRDG CMKESQRRGY CSRHLSMRTK EMEGLADSGP GGAGRPAAVA 
       560        570        580        590        600
AREGSTEFDW GDETSRDSEA SSVAARGDSR PRLVAPADLS RFEFDECEAA 
       610        620        630        640        650
VMLVSLGSSR SGTPSFSPVS TQSPFSPAPS PSPSPLFGFR PANFSPINAS 
       660        670        680        690        700
PVIQRTAVRS RHLSASTPKA GVLTPPDLGP HPPPPAPRER HSSGILPTFQ 
       710        720        730        740        750
TNLTFTVPIS PGRRKTELLP HPGALGAPGA GGGGAAPDFP KSDSLDSGVD 
       760        770        780        790        800
SVSHTPTPST PAGFRAVSPA VPFSRSRQPS PLLLLPPPAG LTSDPGPSVR 
       810        820        830        840        850
RVPAVQRDSP VIVRNPDVPL PSKFPGEVGT AGEVRAGGPG RGCRETPVPP 
       860        870        880        890        900
GVASGKPGLP PPLPAPVPIT VPPAAPTAVA QPMPAFGLAS SPFQPVAFHP 
       910        920        930        940        950
SPAALLPVLV PSSYTSHPAP KKEVIMGRPG TVWTNVEPRS VAVFPWHSLV 
       960        970        980        990       1000
PFLAPSQPDP SVQPSEAQQP ASHPVASNQS KEPAESAAVA HERPPGGTGS 
      1010       1020       1030       1040       1050
ADPERPPGAT CPESPGPGPP HPLGVVESGK GPPPTTEEEA SGPPGEPRLD 
      1060       1070       1080       1090       1100
SETESDHDDA FLSIMSPEIQ LPLPPGKRRT QSLSALPKER DSSSEKDGRS 
      1110       1120       1130       1140       1150
PNKREKDHIR RPMNAFMIFS KRHRALVHQR HPNQDNRTVS KILGEWWYAL 
      1160       1170       1180       1190       1200
GPKEKQKYHD LAFQVKEAHF KAHPDWKWCN KDRKKSSSEA KPTSLGLAGG 
      1210       1220       1230       1240       1250
HKETRERSMS ETGTAAAPGV SSELLSVAAQ TLLSSDTKAP GSSSCGAERL 
      1260       1270       1280       1290       1300
HTVGGPGSAR PRAFSHSGVH SLDGGEVDSQ ALQELTQMVS GPASYSGPKP 
      1310       1320       1330       1340       1350
STQYGAPGPF AAPGEGGALA ATGRPPLLPT RASRSQRAAS EDMTSDEERM 
      1360       1370       1380       1390       1400
VICEEEGDDD VIADDGFGTT DIDLKCKERV TDSESGDSSG EDPEGNKGFG 
      1410       1420       1430       1440       1450
RKVFSPVIRS SFTHCRPPLD PEPPGPPDPP VAFGKGYGSA PSSSASSPAS 
      1460       1470       1480       1490       1500
SSASAATSFS LGSGTFKAQE SGQGSTAGPL RPPPPGAGGP ATPSKATRFL 
      1510       1520       1530       1540       1550
PMDPATFRRK RPESVGGLEP PGPSVIAAPP SGGGNILQTL VLPPNKEEQE 
      1560       1570       1580       1590       1600
GGGARVPSAP APSLAYGAPA APLSRPAATM VTNVVRPVSS TPVPIASKPF 
      1610       1620       1630       1640       1650
PTSGRAEASP NDTAGARTEM GTGSRVPGGS PLGVSLVYSD KKSAAATSPA 
      1660       1670       1680       1690       1700
PHLVAGPLLG TVGKAPATVT NLLVGTPGYG APAPPAVQFI AQGAPGGGTT 
      1710       1720       1730       1740       1750
AGSGAGAGSG PNGPVPLGIL QPGALGKAGG ITQVQYILPT LPQQLQVAPA 
      1760       1770       1780       1790       1800
PAPAPGTKAA APSGPAPTTS IRFTLPPGTS TNGKVLAATA PTPGIPILQS 
      1810       1820       1830       1840       1850
VPSAPPPKAQ SVSPVQAPPP GGSAQLLPGK VLVPLAAPSM SVRGGGAGQP 
      1860       1870       1880       1890       1900
LPLVSPPFSV PVQNGAQPPS KIIQLTPVPV STPSGLVPPL SPATLPGPTS 
      1910       1920       1930       1940       1950
QPQKVLLPSS TRITYVQSAG GHALPLGTSP ASSQAGTVTS YGPTSSVALG 
      1960       1970       1980       1990       2000
FTSLGPSGPA FVQPLLSGQA PLLAPGQVGV SPVPSPQLPP ACAAPGGPVI 
      2010       2020       2030       2040       2050
TAFYSGSPAP TSSAPLAQPS QAPPSLVYTV ATSTTPPAAT ILPKGPPAPA 
      2060       2070       2080       2090       2100
TATPAPTSPF PSATGSMTYS LVAPKAQRPS PKAPQKVKAA IASIPVGSFE 
      2110       2120       2130       2140       2150
AGASGRPGPA PRQPLEPGPV REPTAPESEL EGQPTPPAPP PLPETWTPTA 
      2160       2170       2180       2190       2200
RSSPPLPPPA EERTSAKGPE TMASKFPSSS SDWRVPGQGL ENRGEPPTPP 
      2210       2220       2230       2240       2250
SPAPAPAVAP GGSSESSSGR AAGDTPERKE AAGTGKKVKV RPPPLKKTFD 
      2260       2270       2280       2290       2300
SVDKVLSEVD FEERFAELPE FRPEEVLPSP TLQSLATSPR AILGSYRKKR 
      2310       2320       2330       2340       2350
KNSTDLDSAP EDPTSPKRKM RRRSSCSSEP NTPKSAKCEG DIFTFDRTGT 
      2360       2370       2380       2390       2400
EAEDVLGELE YDKVPYSSLR RTLDQRRALV MQLFQDHGFF PSAQATAAFQ 
      2410       2420       2430       2440       2450
ARYADIFPSK VCLQLKIREV RQKIMQAATP TEQPPGAEAP LPVPPPTGTA 
      2460       2470       2480       2490       2500
AAPAPTPSPA GGPDPTSPSS DSGTAQAAPP LPPPPESGPG QPGWEGAPQP 
      2510 
SPPPPGPSTA ATGR
Length:2,514
Mass (Da):257,749
Last modified:July 11, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29DA35E5B34B6D00
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96RK0CIC_HUMAN
Protein capicua homolog
CIC KIAA0306
1,608Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQR4A0A0A0MQR4_HUMAN
Protein capicua homolog
CIC
1,606Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1Q4I3L1Q4_HUMAN
Protein capicua homolog
CIC
320Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L373I3L373_HUMAN
Protein capicua homolog
CIC
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L135I3L135_HUMAN
Protein capicua homolog
CIC
309Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2I4I3L2I4_HUMAN
Protein capicua homolog
CIC
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC006486 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000572681; ENSP00000459719; ENSG00000079432

UCSC genome browser

More...UCSCi		uc021uvd.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006486 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiI3L2J0, 2 interactors

Proteomic databases

EPDiI3L2J0
jPOSTiI3L2J0
MaxQBiI3L2J0
PeptideAtlasiI3L2J0
PRIDEiI3L2J0
ProteomicsDBi46961

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000572681; ENSP00000459719; ENSG00000079432
UCSCiuc021uvd.2 human

Organism-specific databases

HGNCiHGNC:14214 CIC
OpenTargetsiENSG00000079432

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410ITBG Eukaryota
ENOG4111S7E LUCA
GeneTreeiENSGT00940000159960
OMAiPPETWTP

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CIC human

Gene expression databases

BgeeiENSG00000079432 Expressed in 219 organ(s), highest expression level in right testis
ExpressionAtlasiI3L2J0 baseline and differential

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR032147 DUF4819
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF16090 DUF4819, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI3L2J0_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: I3L2J0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: July 31, 2019
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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