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UniProtKB - I3L1M4 (I3L1M4_HUMAN)
Protein
Submitted name:
Aldehyde dehydrogenase family 3 member A2
Gene
ALDH3A2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 38 | PROSITE-ProRule annotation | 1 | |
Active sitei | 72 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro
GO - Biological processi
- cellular aldehyde metabolic process Source: InterPro
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Aldehyde dehydrogenase family 3 member A2Imported |
Gene namesi | Name:ALDH3A2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:403, ALDH3A2 |
VEuPathDBi | HostDB:ENSG00000072210 |
PTM / Processingi
Proteomic databases
MaxQBi | I3L1M4 |
PeptideAtlasi | I3L1M4 |
PRIDEi | I3L1M4 |
ProteomicsDBi | 46688 |
Expressioni
Gene expression databases
Bgeei | ENSG00000072210, Expressed in adrenal tissue and 245 other tissues |
ExpressionAtlasi | I3L1M4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 136 | AldedhInterPro annotationAdd BLAST | 130 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000157944 |
HOGENOMi | CLU_005391_3_4_1 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR012394, Aldehyde_DH_NAD(P) |
PANTHERi | PTHR43570, PTHR43570, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All
I3L1M4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
TTELLKQRFD HIFYTGNTAV GKIVMEAAAK HLTPVTLELG GKSPCYIDKD
60 70 80 90 100
CDLDIVCRRI TWGKYMNCGQ TCIAPDYILC EASLQNQIVW KIKETVKEFY
110 120 130 140 150
GENIKESPDY ERIINLRHFK RILSLLEGQK IAFGGETDEA TRYIGNGNSP
160
FPMGRWQFGS FC
Computationally mapped potential isoform sequencesi
There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP51648 | AL3A2_HUMAN | Aldehyde dehydrogenase family 3 mem... | ALDH3A2 ALDH10, FALDH | 485 | Annotation score: | ||
A0A5F9ZHI5 | A0A5F9ZHI5_HUMAN | Aldehyde dehydrogenase | ALDH3A2 | 403 | Annotation score: | ||
A0A5F9ZGX4 | A0A5F9ZGX4_HUMAN | Aldehyde dehydrogenase family 3 mem... | ALDH3A2 | 460 | Annotation score: | ||
A0A5F9ZHN9 | A0A5F9ZHN9_HUMAN | Aldehyde dehydrogenase | ALDH3A2 | 521 | Annotation score: | ||
A0A5K1VW72 | A0A5K1VW72_HUMAN | Aldehyde dehydrogenase family 3 mem... | ALDH3A2 | 376 | Annotation score: | ||
A0A5F9ZHP6 | A0A5F9ZHP6_HUMAN | Aldehyde dehydrogenase family 3 mem... | ALDH3A2 | 195 | Annotation score: | ||
J3QS00 | J3QS00_HUMAN | Aldehyde dehydrogenase family 3 mem... | ALDH3A2 | 134 | Annotation score: | ||
J3QRD1 | J3QRD1_HUMAN | Aldehyde dehydrogenase family 3 mem... | ALDH3A2 | 393 | Annotation score: | ||
A0A5F9ZHZ9 | A0A5F9ZHZ9_HUMAN | Aldehyde dehydrogenase family 3 mem... | ALDH3A2 | 233 | Annotation score: | ||
A0A5F9ZI12 | A0A5F9ZI12_HUMAN | Aldehyde dehydrogenase family 3 mem... | ALDH3A2 | 393 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005722 Genomic DNA No translation available. AC115989 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000571537; ENSP00000458942; ENSG00000072210 |
UCSCi | uc060cmx.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005722 Genomic DNA No translation available. AC115989 Genomic DNA No translation available. |
3D structure databases
SMRi | I3L1M4 |
ModBasei | Search... |
Proteomic databases
MaxQBi | I3L1M4 |
PeptideAtlasi | I3L1M4 |
PRIDEi | I3L1M4 |
ProteomicsDBi | 46688 |
Protocols and materials databases
Antibodypediai | 2232, 457 antibodies from 32 providers |
Genome annotation databases
Ensembli | ENST00000571537; ENSP00000458942; ENSG00000072210 |
UCSCi | uc060cmx.1, human |
Organism-specific databases
HGNCi | HGNC:403, ALDH3A2 |
OpenTargetsi | ENSG00000072210 |
VEuPathDBi | HostDB:ENSG00000072210 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157944 |
HOGENOMi | CLU_005391_3_4_1 |
Miscellaneous databases
ChiTaRSi | ALDH3A2, human |
Gene expression databases
Bgeei | ENSG00000072210, Expressed in adrenal tissue and 245 other tissues |
ExpressionAtlasi | I3L1M4, baseline and differential |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR012394, Aldehyde_DH_NAD(P) |
PANTHERi | PTHR43570, PTHR43570, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | I3L1M4_HUMAN | |
Accessioni | I3L1M4Primary (citable) accession number: I3L1M4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | July 11, 2012 | |
Last modified: | January 19, 2022 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |