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Protein
Submitted name:

Uromodulin

Gene

UMOD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
UromodulinImported
Gene namesi
Name:UMODImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169344.15
HGNCiHGNC:12559 UMOD

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169344

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500367525024 – 125Sequence analysisAdd BLAST102

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiI3L1M3
PRIDEiI3L1M3

Expressioni

Gene expression databases

BgeeiENSG00000169344 Expressed in 55 organ(s), highest expression level in renal medulla
ExpressionAtlasiI3L1M3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliI3L1M3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 64EGF-likeInterPro annotationAdd BLAST37
Domaini65 – 107EGF-likeInterPro annotationAdd BLAST43

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IVSV Eukaryota
ENOG410YDU6 LUCA
GeneTreeiENSGT00530000063244

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.iShow all

I3L1M3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQPSLTWML MVVVASWFIT TAATDTSEAR WCSECHSNAT CTEDEAVTTC
60 70 80 90 100
TCQEGFTGDG LTCVDLDECA IPGAHNCSAN SSCVNTPGSF SCVCPEGFRL
110 120
SPGLGCTDVD ECAEPGLSHC HALAT
Length:125
Mass (Da):13,036
Last modified:July 11, 2012 - v1
Checksum:iC9CE95F3E9B5E1F5
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P07911UROM_HUMAN
Uromodulin
UMOD
640Annotation score:
I3L3E0I3L3E0_HUMAN
Uromodulin
UMOD
161Annotation score:
I3L4Y6I3L4Y6_HUMAN
Uromodulin
UMOD
102Annotation score:
I3L3Z4I3L3Z4_HUMAN
Uromodulin
UMOD
161Annotation score:
I3L2J2I3L2J2_HUMAN
Uromodulin
UMOD
88Annotation score:
X6RBG4X6RBG4_HUMAN
Uromodulin
UMOD
689Annotation score:
I3L4B0I3L4B0_HUMAN
Uromodulin
UMOD
86Annotation score:
I3L2K2I3L2K2_HUMAN
Uromodulin
UMOD
138Annotation score:
Q8NHW8Q8NHW8_HUMAN
Uromodulin
UMOD
29Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei125Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106796 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000571174; ENSP00000458939; ENSG00000169344
UCSCiuc059rpw.1 human

Similar proteinsi

Entry informationi

Entry nameiI3L1M3_HUMAN
AccessioniPrimary (citable) accession number: I3L1M3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: September 12, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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