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Protein
Submitted name:

Arachidonate 15-lipoxygenase B

Gene

ALOX15B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Fe cationUniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionDioxygenaseUniRule annotationSAAS annotation, Oxidoreductase
LigandIronUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Arachidonate 15-lipoxygenase BImported
Gene namesi
Name:ALOX15BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000179593.15
HGNCiHGNC:434 ALOX15B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179593

PTM / Processingi

Proteomic databases

PeptideAtlasiI3L1D5
PRIDEiI3L1D5

Expressioni

Gene expression databases

BgeeiENSG00000179593
ExpressionAtlasiI3L1D5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliI3L1D5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 124PLATInterPro annotationAdd BLAST123
Domaini124 – 664LipoxygenaseInterPro annotationAdd BLAST541

Sequence similaritiesi

Belongs to the lipoxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IF0U Eukaryota
ENOG410YN4N LUCA
GeneTreeiENSGT00550000074415

Family and domain databases

InterProiView protein in InterPro
IPR000907 LipOase
IPR013819 LipOase_C
IPR036226 LipOase_C_sf
IPR020834 LipOase_CS
IPR020833 LipOase_Fe_BS
IPR001885 LipOase_mml
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
PANTHERiPTHR11771 PTHR11771, 1 hit
PfamiView protein in Pfam
PF00305 Lipoxygenase, 1 hit
PF01477 PLAT, 1 hit
PRINTSiPR00087 LIPOXYGENASE
PR00467 MAMLPOXGNASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF48484 SSF48484, 1 hit
SSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS00711 LIPOXYGENASE_1, 1 hit
PS00081 LIPOXYGENASE_2, 1 hit
PS51393 LIPOXYGENASE_3, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

I3L1D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFRVRVST GEAFGAGTWD KVSVSIVGTR GESPPLPLDN LGKEFTAGAE
60 70 80 90 100
EDFQVTLPED VGRVLLLRVH KAPPVLPLLG PLAPDAWFCR WFQLTPPRGG
110 120 130 140 150
HLLFPCYQWL EGAGTLVLQE GTAKVSWADH HPVLQQQRQE ELQARQEMYQ
160 170 180 190 200
WKAYNPGWPH CLDEKTVEDL ELNIKYSTAK NANFYLQAGS AFAEMKIKGL
210 220 230 240 250
LDRKGLWRSL NEMKRIFNFR RTPAAEHAFE HWQEDAFFAS QFLNGLNPVL
260 270 280 290 300
IRRCHYLPKN FPVTDAMVAS VLGPGTSLQA ELEKGSLFLV DHGILSGIQT
310 320 330 340 350
NVINGKPQFS AAPMTLLYQS PGCGPLLPLA IQLSQTPGPN SPIFLPTDDK
360 370 380 390 400
WDWLLAKTWV RNAEFSFHEA LTHLLHSHLL PEVFTLATLR QLPHCHPLFK
410 420 430 440 450
LLIPHTRYTL HINTLARELL IVPGQVVDRS TGIGIEGFSE LIQRNMKQLN
460 470 480 490 500
YSLLCLPEDI RTRGVEDIPG YYYRDDGMQI WGAVERDESV QDDRELQAWV
510 520 530 540 550
REIFSKGFLN QESSGIPSSL ETREALVQYV TMVIFTCSAK HAAVSAGQFD
560 570 580 590 600
SCAWMPNLPP SMQLPPPTSK GLATCEGFIA TLPPVNATCD VILALWLLSK
610 620 630 640 650
EPGDQRPLGT YPDEHFTEEA PRRSIATFQS RLAQISRGIQ ERNQGLVLPY
660
TYLDPPLIEN SVSI
Length:664
Mass (Da):74,487
Last modified:July 11, 2012 - v1
Checksum:i65330422A5F545C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129492 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000572022; ENSP00000458749; ENSG00000179593
UCSCiuc010vun.3 human

Similar proteinsi

Entry informationi

Entry nameiI3L1D5_HUMAN
AccessioniPrimary (citable) accession number: I3L1D5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: March 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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