UniProtKB - I3L1D5 (I3L1D5_HUMAN)
Protein
Submitted name:
Polyunsaturated fatty acid lipoxygenase ALOX15B
Gene
ALOX15B
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Fe cationUniRule annotationARBA annotation
: Lipid metabolism Pathwayi
This protein is involved in Lipid metabolism.ARBA annotationView all proteins of this organism that are known to be involved in Lipid metabolism.
GO - Molecular functioni
- iron ion binding Source: InterPro
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Source: InterPro
Keywordsi
Molecular function | DioxygenaseUniRule annotationARBA annotation, Oxidoreductase |
Ligand | IronUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Polyunsaturated fatty acid lipoxygenase ALOX15BImported |
Gene namesi | Name:ALOX15BImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000179593.15 |
HGNCi | HGNC:434, ALOX15B |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Keywords - Cellular componenti
CytoplasmARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000179593, Expressed in mammalian vulva and 129 other tissues |
ExpressionAtlasi | I3L1D5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 124 | PLATInterPro annotationAdd BLAST | 123 | |
Domaini | 124 – 664 | LipoxygenaseInterPro annotationAdd BLAST | 541 |
Sequence similaritiesi
Belongs to the lipoxygenase family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000161510 |
Family and domain databases
CDDi | cd01753, PLAT_LOX, 1 hit |
InterProi | View protein in InterPro IPR000907, LipOase IPR013819, LipOase_C IPR036226, LipOase_C_sf IPR020834, LipOase_CS IPR020833, LipOase_Fe_BS IPR001885, LipOase_mml IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR042062, PLAT_LOX_verte |
PANTHERi | PTHR11771, PTHR11771, 1 hit |
Pfami | View protein in Pfam PF00305, Lipoxygenase, 1 hit PF01477, PLAT, 1 hit |
PRINTSi | PR00087, LIPOXYGENASE PR00467, MAMLPOXGNASE |
SMARTi | View protein in SMART SM00308, LH2, 1 hit |
SUPFAMi | SSF48484, SSF48484, 1 hit SSF49723, SSF49723, 1 hit |
PROSITEi | View protein in PROSITE PS00711, LIPOXYGENASE_1, 1 hit PS00081, LIPOXYGENASE_2, 1 hit PS51393, LIPOXYGENASE_3, 1 hit PS50095, PLAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
I3L1D5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEFRVRVST GEAFGAGTWD KVSVSIVGTR GESPPLPLDN LGKEFTAGAE
60 70 80 90 100
EDFQVTLPED VGRVLLLRVH KAPPVLPLLG PLAPDAWFCR WFQLTPPRGG
110 120 130 140 150
HLLFPCYQWL EGAGTLVLQE GTAKVSWADH HPVLQQQRQE ELQARQEMYQ
160 170 180 190 200
WKAYNPGWPH CLDEKTVEDL ELNIKYSTAK NANFYLQAGS AFAEMKIKGL
210 220 230 240 250
LDRKGLWRSL NEMKRIFNFR RTPAAEHAFE HWQEDAFFAS QFLNGLNPVL
260 270 280 290 300
IRRCHYLPKN FPVTDAMVAS VLGPGTSLQA ELEKGSLFLV DHGILSGIQT
310 320 330 340 350
NVINGKPQFS AAPMTLLYQS PGCGPLLPLA IQLSQTPGPN SPIFLPTDDK
360 370 380 390 400
WDWLLAKTWV RNAEFSFHEA LTHLLHSHLL PEVFTLATLR QLPHCHPLFK
410 420 430 440 450
LLIPHTRYTL HINTLARELL IVPGQVVDRS TGIGIEGFSE LIQRNMKQLN
460 470 480 490 500
YSLLCLPEDI RTRGVEDIPG YYYRDDGMQI WGAVERDESV QDDRELQAWV
510 520 530 540 550
REIFSKGFLN QESSGIPSSL ETREALVQYV TMVIFTCSAK HAAVSAGQFD
560 570 580 590 600
SCAWMPNLPP SMQLPPPTSK GLATCEGFIA TLPPVNATCD VILALWLLSK
610 620 630 640 650
EPGDQRPLGT YPDEHFTEEA PRRSIATFQS RLAQISRGIQ ERNQGLVLPY
660
TYLDPPLIEN SVSI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketO15296 | LX15B_HUMAN | Polyunsaturated fatty acid lipoxyge... | ALOX15B | 676 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC129492 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000572022; ENSP00000458749; ENSG00000179593 |
UCSCi | uc010vun.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC129492 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | I3L1D5 |
PRIDEi | I3L1D5 |
ProteomicsDBi | 46609 |
Protocols and materials databases
Antibodypediai | 12373, 251 antibodies |
Genome annotation databases
Ensembli | ENST00000572022; ENSP00000458749; ENSG00000179593 |
UCSCi | uc010vun.3, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000179593.15 |
HGNCi | HGNC:434, ALOX15B |
OpenTargetsi | ENSG00000179593 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161510 |
Miscellaneous databases
ChiTaRSi | ALOX15B, human |
Gene expression databases
Bgeei | ENSG00000179593, Expressed in mammalian vulva and 129 other tissues |
ExpressionAtlasi | I3L1D5, baseline and differential |
Family and domain databases
CDDi | cd01753, PLAT_LOX, 1 hit |
InterProi | View protein in InterPro IPR000907, LipOase IPR013819, LipOase_C IPR036226, LipOase_C_sf IPR020834, LipOase_CS IPR020833, LipOase_Fe_BS IPR001885, LipOase_mml IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR042062, PLAT_LOX_verte |
PANTHERi | PTHR11771, PTHR11771, 1 hit |
Pfami | View protein in Pfam PF00305, Lipoxygenase, 1 hit PF01477, PLAT, 1 hit |
PRINTSi | PR00087, LIPOXYGENASE PR00467, MAMLPOXGNASE |
SMARTi | View protein in SMART SM00308, LH2, 1 hit |
SUPFAMi | SSF48484, SSF48484, 1 hit SSF49723, SSF49723, 1 hit |
PROSITEi | View protein in PROSITE PS00711, LIPOXYGENASE_1, 1 hit PS00081, LIPOXYGENASE_2, 1 hit PS51393, LIPOXYGENASE_3, 1 hit PS50095, PLAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I3L1D5_HUMAN | |
Accessioni | I3L1D5Primary (citable) accession number: I3L1D5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | July 11, 2012 | |
Last modified: | August 12, 2020 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |