ALOX15B

Functionⁱ

Cofactorⁱ

Fe cationUniRule annotationSAAS annotation

GO - Molecular functionⁱ

iron ion binding Source: InterPro
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DioxygenaseUniRule annotationSAAS annotation, Oxidoreductase
Ligand	IronUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Arachidonate 15-lipoxygenase BImported
Gene namesⁱ	Name:ALOX15BImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179593.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:434 ALOX15B

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000179593

OpenTargetsⁱ

ENSG00000179593

PTM / Processingⁱ

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	I3L1D5
PRIDEⁱ	I3L1D5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000179593
ExpressionAtlasⁱ	I3L1D5 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	I3L1D5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 124	PLATInterPro annotationAdd BLAST		123
Domainⁱ	124 – 664	LipoxygenaseInterPro annotationAdd BLAST		541

Sequence similaritiesⁱ

Belongs to the lipoxygenase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IF0U Eukaryota ENOG410YN4N LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074415

Family and domain databases

InterProⁱ	View protein in InterPro IPR000907 LipOase IPR013819 LipOase_C IPR036226 LipOase_C_sf IPR020834 LipOase_CS IPR020833 LipOase_Fe_BS IPR001885 LipOase_mml IPR001024 PLAT/LH2_dom IPR036392 PLAT/LH2_dom_sf
PANTHERⁱ	PTHR11771 PTHR11771, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00305 Lipoxygenase, 1 hit PF01477 PLAT, 1 hit
PRINTSⁱ	PR00087 LIPOXYGENASE PR00467 MAMLPOXGNASE
SMARTⁱ	View protein in SMART SM00308 LH2, 1 hit
SUPFAMⁱ	SSF48484 SSF48484, 1 hit SSF49723 SSF49723, 1 hit
PROSITEⁱ	View protein in PROSITE PS00711 LIPOXYGENASE_1, 1 hit PS00081 LIPOXYGENASE_2, 1 hit PS51393 LIPOXYGENASE_3, 1 hit PS50095 PLAT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

I3L1D5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEFRVRVST GEAFGAGTWD KVSVSIVGTR GESPPLPLDN LGKEFTAGAE 
        60         70         80         90        100
EDFQVTLPED VGRVLLLRVH KAPPVLPLLG PLAPDAWFCR WFQLTPPRGG 
       110        120        130        140        150
HLLFPCYQWL EGAGTLVLQE GTAKVSWADH HPVLQQQRQE ELQARQEMYQ 
       160        170        180        190        200
WKAYNPGWPH CLDEKTVEDL ELNIKYSTAK NANFYLQAGS AFAEMKIKGL 
       210        220        230        240        250
LDRKGLWRSL NEMKRIFNFR RTPAAEHAFE HWQEDAFFAS QFLNGLNPVL 
       260        270        280        290        300
IRRCHYLPKN FPVTDAMVAS VLGPGTSLQA ELEKGSLFLV DHGILSGIQT 
       310        320        330        340        350
NVINGKPQFS AAPMTLLYQS PGCGPLLPLA IQLSQTPGPN SPIFLPTDDK 
       360        370        380        390        400
WDWLLAKTWV RNAEFSFHEA LTHLLHSHLL PEVFTLATLR QLPHCHPLFK 
       410        420        430        440        450
LLIPHTRYTL HINTLARELL IVPGQVVDRS TGIGIEGFSE LIQRNMKQLN 
       460        470        480        490        500
YSLLCLPEDI RTRGVEDIPG YYYRDDGMQI WGAVERDESV QDDRELQAWV 
       510        520        530        540        550
REIFSKGFLN QESSGIPSSL ETREALVQYV TMVIFTCSAK HAAVSAGQFD 
       560        570        580        590        600
SCAWMPNLPP SMQLPPPTSK GLATCEGFIA TLPPVNATCD VILALWLLSK 
       610        620        630        640        650
EPGDQRPLGT YPDEHFTEEA PRRSIATFQS RLAQISRGIQ ERNQGLVLPY 
       660 
TYLDPPLIEN SVSI

Length:664

Mass (Da):74,487

Last modified:July 11, 2012 - v1

Checksum:ⁱ65330422A5F545C6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC129492 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC129492 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000572022; ENSP00000458749; ENSG00000179593
UCSC genome browser More...UCSCⁱ	uc010vun.3 human

Protein	Similar proteins		Species	Score	Length
I3L1D5	Arachidonate 15-lipoxygenase B	)	HUMAN		676
Arachidonate 15-lipoxygenase, type B		AOTNA		677
Arachidonate 15-lipoxygenase, type B		COLAP		676
Arachidonate 15-lipoxygenase, type B		PONAB		676
Arachidonate 15-lipoxygenase, type B		PANTR		676
+28

Protein	Similar proteins		Species	Score	Length
I3L1D5	Arachidonate 15-lipoxygenase B	)	HUMAN		676
Arachidonate 15-lipoxygenase, type B		AOTNA		677
Arachidonate 15-lipoxygenase, type B		COLAP		676
Arachidonate 15-lipoxygenase, type B		RHIBE		676
Arachidonate 15-lipoxygenase, type B		CERAT		676
+41

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC129492 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC129492 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	I3L1D5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	I3L1D5
PRIDEⁱ	I3L1D5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000572022; ENSP00000458749; ENSG00000179593
UCSC genome browser More...UCSCⁱ	uc010vun.3 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179593.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:434 ALOX15B
Open Targets More...OpenTargetsⁱ	ENSG00000179593
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF0U Eukaryota ENOG410YN4N LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074415

Miscellaneous databases

ChiTaRSⁱ	ALOX15B human

ChiTaRSⁱ

ALOX15B human

Gene expression databases

Bgeeⁱ	ENSG00000179593
ExpressionAtlasⁱ	I3L1D5 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR000907 LipOase IPR013819 LipOase_C IPR036226 LipOase_C_sf IPR020834 LipOase_CS IPR020833 LipOase_Fe_BS IPR001885 LipOase_mml IPR001024 PLAT/LH2_dom IPR036392 PLAT/LH2_dom_sf
PANTHERⁱ	PTHR11771 PTHR11771, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00305 Lipoxygenase, 1 hit PF01477 PLAT, 1 hit
PRINTSⁱ	PR00087 LIPOXYGENASE PR00467 MAMLPOXGNASE
SMARTⁱ	View protein in SMART SM00308 LH2, 1 hit
SUPFAMⁱ	SSF48484 SSF48484, 1 hit SSF49723 SSF49723, 1 hit
PROSITEⁱ	View protein in PROSITE PS00711 LIPOXYGENASE_1, 1 hit PS00081 LIPOXYGENASE_2, 1 hit PS51393 LIPOXYGENASE_3, 1 hit PS50095 PLAT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	I3L1D5_HUMAN
Accessionⁱ	I3L1D5Primary (citable) accession number: I3L1D5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 11, 2012
	Last sequence update:	July 11, 2012
	Last modified:	March 28, 2018
	This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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UniProtKB - I3L1D5 (I3L1D5_HUMAN)

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Arachidonate 15-lipoxygenase B

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ