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Protein
Submitted name:

Sex hormone-binding globulin, isoform CRA_a

Gene

SHBG

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Sex hormone-binding globulin, isoform CRA_aImported
Gene namesi
Name:SHBGImported
ORF Names:hCG_42018Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000129214.14
HGNCiHGNC:10839 SHBG

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000129214

PTM / Processingi

Proteomic databases

PeptideAtlasiI3L145
PRIDEiI3L145

Expressioni

Gene expression databases

BgeeiENSG00000129214 Expressed in 92 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiI3L145 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 159LAM_G_DOMAINInterPro annotationAdd BLAST159

Phylogenomic databases

eggNOGiENOG410IKW6 Eukaryota
ENOG410YKMT LUCA
GeneTreeiENSGT00530000063339
HOVERGENiHBG017800

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00054 Laminin_G_1, 1 hit
SMARTiView protein in SMART
SM00282 LamG, 1 hit
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS50025 LAM_G_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.iShow all

I3L145-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFDLTKITK TSSSFEVRTW DPEGVIFYGD TNPKDDWFML GLRDGRPEIQ
60 70 80 90 100
LHNHWAQLTV GAGPRLDDGR WHQVEVKMEG DSVLLEVDGE EVLRLRQVSG
110 120 130 140 150
PLTSKRHPIM RIALGGLLFP ASNLRLPLVP ALDGCLRRDS WLDKQAEISA
160 170 180 190 200
SAPTSLRSCD VESNPGIFLP PGTQAEFNLR DIPQPHAEPW AFSLDLGLKQ
210 220 230 240 250
AAGSGHLLAL GTPENPSWLS LHLQDQKVVL SSGSGPGLDL PLVLGLPLQL
260 270 280 290 300
KLSMSRVVLS QGSKMKALAL PPLGLAPLLN LWAKPQGRLF LGALPGEDSS
310 320 330 340
TSFCLNGLWA QGQRLDVDQA LNRSHEIWTH SCPQSPGNGT DASH
Length:344
Mass (Da):37,488
Last modified:July 11, 2012 - v1
Checksum:i30087AA6D4E2BCD4
GO

Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P04278SHBG_HUMAN
Sex hormone-binding globulin
SHBG
402Annotation score:
I3L0M1I3L0M1_HUMAN
Sex hormone-binding globulin
SHBG
181Annotation score:
B4DYU0B4DYU0_HUMAN
cDNA FLJ51403, highly similar to Se...
SHBG
235Annotation score:
I3L4D0I3L4D0_HUMAN
Sex hormone-binding globulin
SHBG
57Annotation score:
B0FWH6B0FWH6_HUMAN
Sex hormone-binding globulin
SHBG
206Annotation score:
I3L1J1I3L1J1_HUMAN
Sex hormone-binding globulin
SHBG
229Annotation score:
B0FWH7B0FWH7_HUMAN
Sex hormone-binding globulin
SHBG
113Annotation score:
I3L4B9I3L4B9_HUMAN
Sex hormone-binding globulin
SHBG
175Annotation score:
I3L2X4I3L2X4_HUMAN
Sex hormone-binding globulin
SHBG
290Annotation score:
I3L1G4I3L1G4_HUMAN
Sex hormone-binding globulin
SHBG
82Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007421 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90149.1
RefSeqiNP_001276042.1, NM_001289113.1
NP_001276043.1, NM_001289114.1
UniGeneiHs.632235

Genome annotation databases

EnsembliENST00000340624; ENSP00000345675; ENSG00000129214
ENST00000575314; ENSP00000458559; ENSG00000129214
GeneIDi6462
UCSCiuc010cmt.4 human

Similar proteinsi

Entry informationi

Entry nameiI3L145_HUMAN
AccessioniPrimary (citable) accession number: I3L145
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: September 12, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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