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UniProtKB - I3L145 (I3L145_HUMAN)
Protein
Submitted name:
Sex hormone-binding globulin
Gene
SHBG
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Names & Taxonomyi
Protein namesi | Submitted name: Sex hormone-binding globulinSubmitted name: Sex hormone-binding globulin, isoform CRA_aImported |
Gene namesi | Name:SHBGImported ORF Names:hCG_42018Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10839, SHBG |
VEuPathDBi | HostDB:ENSG00000129214 |
Expressioni
Gene expression databases
Bgeei | ENSG00000129214, Expressed in right lobe of liver and 115 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 159 | LAM_G_DOMAINInterPro annotationAdd BLAST | 159 |
Phylogenomic databases
GeneTreei | ENSGT00940000154035 |
HOGENOMi | CLU_063172_0_0_1 |
Family and domain databases
CDDi | cd00110, LamG, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR001791, Laminin_G |
Pfami | View protein in Pfam PF00054, Laminin_G_1, 1 hit |
SMARTi | View protein in SMART SM00282, LamG, 1 hit |
SUPFAMi | SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS50025, LAM_G_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All
I3L145-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTFDLTKITK TSSSFEVRTW DPEGVIFYGD TNPKDDWFML GLRDGRPEIQ
60 70 80 90 100
LHNHWAQLTV GAGPRLDDGR WHQVEVKMEG DSVLLEVDGE EVLRLRQVSG
110 120 130 140 150
PLTSKRHPIM RIALGGLLFP ASNLRLPLVP ALDGCLRRDS WLDKQAEISA
160 170 180 190 200
SAPTSLRSCD VESNPGIFLP PGTQAEFNLR DIPQPHAEPW AFSLDLGLKQ
210 220 230 240 250
AAGSGHLLAL GTPENPSWLS LHLQDQKVVL SSGSGPGLDL PLVLGLPLQL
260 270 280 290 300
KLSMSRVVLS QGSKMKALAL PPLGLAPLLN LWAKPQGRLF LGALPGEDSS
310 320 330 340
TSFCLNGLWA QGQRLDVDQA LNRSHEIWTH SCPQSPGNGT DASH
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP04278 | SHBG_HUMAN | Sex hormone-binding globulin | SHBG | 402 | Annotation score: | ||
A0A0C4DGN2 | A0A0C4DGN2_HUMAN | Sex hormone-binding globulin | SHBG | 260 | Annotation score: | ||
B0FWH6 | B0FWH6_HUMAN | Sex hormone-binding globulin | SHBG | 206 | Annotation score: | ||
B0FWH7 | B0FWH7_HUMAN | Sex hormone-binding globulin | SHBG | 113 | Annotation score: | ||
I3L0M1 | I3L0M1_HUMAN | Sex hormone-binding globulin | SHBG | 181 | Annotation score: | ||
B4DYU0 | B4DYU0_HUMAN | Sex hormone-binding globulin | SHBG | 235 | Annotation score: | ||
I3L4D0 | I3L4D0_HUMAN | Sex hormone-binding globulin | SHBG | 57 | Annotation score: | ||
I3L1C1 | I3L1C1_HUMAN | Sex hormone-binding globulin | SHBG | 93 | Annotation score: | ||
I3L2X4 | I3L2X4_HUMAN | Sex hormone-binding globulin | SHBG | 290 | Annotation score: | ||
I3L1J1 | I3L1J1_HUMAN | Sex hormone-binding globulin | SHBG | 229 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007421 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90149.1 |
RefSeqi | NP_001276042.1, NM_001289113.1 NP_001276043.1, NM_001289114.1 |
Genome annotation databases
Ensembli | ENST00000340624.9; ENSP00000345675.6; ENSG00000129214.15 ENST00000575314.5; ENSP00000458559.1; ENSG00000129214.15 |
GeneIDi | 6462 |
UCSCi | uc010cmt.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007421 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90149.1 |
RefSeqi | NP_001276042.1, NM_001289113.1 NP_001276043.1, NM_001289114.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 46529 |
Protocols and materials databases
Antibodypediai | 24226, 725 antibodies from 36 providers |
DNASUi | 6462 |
Genome annotation databases
Ensembli | ENST00000340624.9; ENSP00000345675.6; ENSG00000129214.15 ENST00000575314.5; ENSP00000458559.1; ENSG00000129214.15 |
GeneIDi | 6462 |
UCSCi | uc010cmt.4, human |
Organism-specific databases
CTDi | 6462 |
HGNCi | HGNC:10839, SHBG |
OpenTargetsi | ENSG00000129214 |
VEuPathDBi | HostDB:ENSG00000129214 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154035 |
HOGENOMi | CLU_063172_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 6462, 15 hits in 1068 CRISPR screens |
ChiTaRSi | SHBG, human |
GenomeRNAii | 6462 |
Gene expression databases
Bgeei | ENSG00000129214, Expressed in right lobe of liver and 115 other tissues |
Family and domain databases
CDDi | cd00110, LamG, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR001791, Laminin_G |
Pfami | View protein in Pfam PF00054, Laminin_G_1, 1 hit |
SMARTi | View protein in SMART SM00282, LamG, 1 hit |
SUPFAMi | SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS50025, LAM_G_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | I3L145_HUMAN | |
Accessioni | I3L145Primary (citable) accession number: I3L145 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2012 |
Last sequence update: | July 11, 2012 | |
Last modified: | May 25, 2022 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |