UniProtKB - I3L145 (I3L145_HUMAN)

BLAST

>tr|I3L145|I3L145_HUMAN Sex hormone-binding globulin, isoform CRA_a OS=Homo sapiens OX=9606 GN=SHBG PE=1 SV=1
MTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTV
GAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFP
ASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLR
DIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDL
PLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSS
TSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH

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History
Entry version 59 (07 Nov 2018)
Sequence version 1 (11 Jul 2012)
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Protein

Submitted name:

Sex hormone-binding globulin, isoform CRA_a

Gene

SHBG

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Sex hormone-binding globulin, isoform CRA_aImported
Gene namesⁱ	Name:SHBGImported ORF Names:hCG_42018Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000129214.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10839 SHBG

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000129214

OpenTargetsⁱ

ENSG00000129214

PTM / Processingⁱ

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	I3L145
PRIDEⁱ	I3L145

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000129214 Expressed in 92 organ(s), highest expression level in right lobe of liver
ExpressionAtlasⁱ	I3L145 baseline and differential

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 159	LAM_G_DOMAINInterPro annotationAdd BLAST		159

Phylogenomic databases

eggNOGⁱ	ENOG410IKW6 Eukaryota ENOG410YKMT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150853
HOVERGENⁱ	HBG017800

Family and domain databases

InterProⁱ	View protein in InterPro IPR013320 ConA-like_dom_sf IPR001791 Laminin_G
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00054 Laminin_G_1, 1 hit
SMARTⁱ	View protein in SMART SM00282 LamG, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 2 hits
PROSITEⁱ	View protein in PROSITE PS50025 LAM_G_DOMAIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show all Align All

I3L145-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MTFDLTKITK TSSSFEVRTW DPEGVIFYGD TNPKDDWFML GLRDGRPEIQ 
        60         70         80         90        100
LHNHWAQLTV GAGPRLDDGR WHQVEVKMEG DSVLLEVDGE EVLRLRQVSG 
       110        120        130        140        150
PLTSKRHPIM RIALGGLLFP ASNLRLPLVP ALDGCLRRDS WLDKQAEISA 
       160        170        180        190        200
SAPTSLRSCD VESNPGIFLP PGTQAEFNLR DIPQPHAEPW AFSLDLGLKQ 
       210        220        230        240        250
AAGSGHLLAL GTPENPSWLS LHLQDQKVVL SSGSGPGLDL PLVLGLPLQL 
       260        270        280        290        300
KLSMSRVVLS QGSKMKALAL PPLGLAPLLN LWAKPQGRLF LGALPGEDSS 
       310        320        330        340 
TSFCLNGLWA QGQRLDVDQA LNRSHEIWTH SCPQSPGNGT DASH

Length:344

Mass (Da):37,488

Last modified:July 11, 2012 - v1

Checksum:ⁱ30087AA6D4E2BCD4

Computationally mapped potential isoform sequencesⁱ

There are 14 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	P04278	SHBG_HUMAN	Sex hormone-binding globulin Sex hormone-binding globulin, SHBG (Sex steroid-binding protein, SBP) (Testis-specific androgen-binding protein, ABP) (Testosterone-estradiol-binding globulin, TeBG) (Testosterone-estrogen-binding globulin)	SHBG	402	Annotation score:
	B4DYU0	B4DYU0_HUMAN	cDNA FLJ51403, highly similar to Se... cDNA FLJ51403, highly similar to Sex hormone-binding globulin	SHBG	235	Annotation score:
	I3L0M1	I3L0M1_HUMAN	Sex hormone-binding globulin Sex hormone-binding globulin	SHBG	181	Annotation score:
	I3L4D0	I3L4D0_HUMAN	Sex hormone-binding globulin Sex hormone-binding globulin	SHBG	57	Annotation score:
	B0FWH6	B0FWH6_HUMAN	Sex hormone-binding globulin Sex hormone-binding globulin	SHBG	206	Annotation score:
	I3L1J1	I3L1J1_HUMAN	Sex hormone-binding globulin Sex hormone-binding globulin	SHBG	229	Annotation score:
	B0FWH7	B0FWH7_HUMAN	Sex hormone-binding globulin Sex hormone-binding globulin	SHBG	113	Annotation score:
	I3L4B9	I3L4B9_HUMAN	Sex hormone-binding globulin Sex hormone-binding globulin	SHBG	175	Annotation score:
	I3L2X4	I3L2X4_HUMAN	Sex hormone-binding globulin Sex hormone-binding globulin	SHBG	290	Annotation score:
	I3L1C1	I3L1C1_HUMAN	Sex hormone-binding globulin Sex hormone-binding globulin	SHBG	93	Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC007421 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90149.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001276042.1, NM_001289113.1 NP_001276043.1, NM_001289114.1
UniGeneⁱ	Hs.632235

Genome annotation databases

Ensemblⁱ	ENST00000340624; ENSP00000345675; ENSG00000129214 ENST00000575314; ENSP00000458559; ENSG00000129214
GeneIDⁱ	6462
UCSC genome browser More...UCSCⁱ	uc010cmt.4 human

Protein	Similar proteins		Species	Score	Length	Source
I3L145	Sex hormone-binding globulin	)	HUMAN		402	UniRef100_P04278
Sex hormone-binding globulin (Fragment)		HUMAN		93
Sex hormone binding globulin (Fragment)		HUMAN		37
UPI0000112437		HUMAN		189
UPI0000112134		HUMAN		177
+1

Protein	Similar proteins		Species	Score	Length	Source
I3L145	Sex hormone-binding globulin	)	HUMAN		402	UniRef90_P04278
Uncharacterized protein		CHLSB		495
Uncharacterized protein		MACNE		492
Sex hormone binding globulin		GORGO		405
SHBG isoform 20 (Fragment)		PANTR		93
+50

Protein	Similar proteins		Species	Score	Length	Source
I3L145	Sex hormone-binding globulin	)	HUMAN		402	UniRef50_P04278
Sex hormone-binding globulin		RABIT		398
Sex hormone-binding globulin		CROCR		393
Sex hormone-binding globulin		PHOSU		399
Sex hormone-binding globulin		RAT		403
+199

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC007421 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90149.1
RefSeqⁱ	NP_001276042.1, NM_001289113.1 NP_001276043.1, NM_001289114.1
UniGeneⁱ	Hs.632235

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlasⁱ	I3L145
PRIDEⁱ	I3L145

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000340624; ENSP00000345675; ENSG00000129214 ENST00000575314; ENSP00000458559; ENSG00000129214
GeneIDⁱ	6462
UCSCⁱ	uc010cmt.4 human

Organism-specific databases

CTDⁱ	6462
EuPathDBⁱ	HostDB:ENSG00000129214.14
HGNCⁱ	HGNC:10839 SHBG
OpenTargetsⁱ	ENSG00000129214
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IKW6 Eukaryota ENOG410YKMT LUCA
GeneTreeⁱ	ENSGT00930000150853
HOVERGENⁱ	HBG017800

Miscellaneous databases

ChiTaRSⁱ	SHBG human
GenomeRNAiⁱ	6462

Gene expression databases

Bgeeⁱ	ENSG00000129214 Expressed in 92 organ(s), highest expression level in right lobe of liver
ExpressionAtlasⁱ	I3L145 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR013320 ConA-like_dom_sf IPR001791 Laminin_G
Pfamⁱ	View protein in Pfam PF00054 Laminin_G_1, 1 hit
SMARTⁱ	View protein in SMART SM00282 LamG, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 2 hits
PROSITEⁱ	View protein in PROSITE PS50025 LAM_G_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	I3L145_HUMAN
Accessionⁱ	I3L145Primary (citable) accession number: I3L145
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 11, 2012
	Last sequence update:	July 11, 2012
	Last modified:	November 7, 2018
	This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB - I3L145 (I3L145_HUMAN)

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Sex hormone-binding globulin, isoform CRA_a

SHBG

Select a section on the left to see content.

Functionⁱ

Caution

Names & Taxonomyⁱ

Organism-specific databases

Pathology & Biotechⁱ

Organism-specific databases

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence (1+)ⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

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UniParc

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UniRef

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Supporting data

UniProtKB - I3L145 (I3L145_HUMAN)

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Sex hormone-binding globulin, isoform CRA_a

SHBG

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

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Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ