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Protein

Derlin

Gene

DERL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DerlinUniRule annotation
Gene namesi
Name:DERL2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000072849.10
HGNCiHGNC:17943 DERL2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 42HelicalUniRule annotationAdd BLAST23
Transmembranei54 – 78HelicalUniRule annotationAdd BLAST25
Transmembranei90 – 108HelicalUniRule annotationAdd BLAST19
Transmembranei120 – 136HelicalUniRule annotationAdd BLAST17
Transmembranei156 – 186HelicalUniRule annotationAdd BLAST31

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000072849

PTM / Processingi

Proteomic databases

MaxQBiI3L0R8
PeptideAtlasiI3L0R8
PRIDEiI3L0R8

Expressioni

Gene expression databases

BgeeiENSG00000072849 Expressed in 220 organ(s), highest expression level in right testis
ExpressionAtlasiI3L0R8 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliI3L0R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the derlin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063156

Family and domain databases

InterProiView protein in InterPro
IPR007599 DER1
PANTHERiPTHR11009 PTHR11009, 1 hit
PfamiView protein in Pfam
PF04511 DER1, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

I3L0R8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYQSLRLEY LQIPPVSRAY TTACVLTTAA VQLELITPFQ LYFNPELIFK
60 70 80 90 100
HFQIWRLITN FLFFGPVGFN FLFNMIFLYR YCRMLEEGSF RGRTADFVFM
110 120 130 140 150
FLFGGFLMTQ SDRMSKSKEL LTQAFTIMLV YVWSRRNPYV RMNFFGLLNF
160 170 180 190 200
QAPFLPWVLM GFSLLLGNSI IVDLLGIAVG HIYFFLEDVF PNQPGGIRIL
Length:200
Mass (Da):23,426
Last modified:July 11, 2012 - v1
Checksum:i4CDDE4167489F7F3
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9GZP9DERL2_HUMAN
Derlin-2
DERL2 DER2, FLANA, CGI-101, SBBI53
239Annotation score:
I3L1S8I3L1S8_HUMAN
Derlin
DERL2
144Annotation score:
I3L1T3I3L1T3_HUMAN
Derlin
DERL2
158Annotation score:
I3L1W3I3L1W3_HUMAN
Derlin
DERL2
103Annotation score:
I3L4W7I3L4W7_HUMAN
Derlin-2
DERL2
79Annotation score:
K7EQE8K7EQE8_HUMAN
Derlin-2
DERL2
82Annotation score:
I3L3R8I3L3R8_HUMAN
Derlin-2
DERL2
74Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei200Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004148 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000571971; ENSP00000458296; ENSG00000072849
UCSCiuc060ach.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004148 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliI3L0R8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiI3L0R8
PeptideAtlasiI3L0R8
PRIDEiI3L0R8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000571971; ENSP00000458296; ENSG00000072849
UCSCiuc060ach.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000072849.10
HGNCiHGNC:17943 DERL2
OpenTargetsiENSG00000072849
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063156

Miscellaneous databases

ChiTaRSiDERL2 human

Gene expression databases

BgeeiENSG00000072849 Expressed in 220 organ(s), highest expression level in right testis
ExpressionAtlasiI3L0R8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR007599 DER1
PANTHERiPTHR11009 PTHR11009, 1 hit
PfamiView protein in Pfam
PF04511 DER1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI3L0R8_HUMAN
AccessioniPrimary (citable) accession number: I3L0R8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: September 12, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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